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Human Lymphocyte Biology and Its Application to Humanized Mice

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Neuroimmune Pharmacology

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Abstract

This chapter describes lymphocyte maturation and differentiation. Interactions of lymphoid tissues with the central and peripheral nervous systems play a fundamental role in health and disease. Recent advances in xenobiology has opened new approaches to study relationships between peripheral immunity and nervous system development, homeostasis, response to injuries, and disease in animal models. Humanized animal models help to study the complexity of human immune system development and adaptive immune responses. Humanization of a mouse brain with human glial cells provides an additional tool to study hemato-lymphoid brain interactions in small animals.

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Authors and Affiliations

  1. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE, 68198-5880, USA

    Larisa Y. Poluektova

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  1. Larisa Y. Poluektova
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Correspondence to Larisa Y. Poluektova .

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  1. Departments of Pharmacology and Experimental Therapeutics and Neurology, Boston University School of Medicine, Boston, Massachusetts, USA

    Tsuneya Ikezu

  2. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Nebraska Medical Center, Omaha, Nebraska, USA

    Howard E. Gendelman

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Poluektova, L.Y. (2017). Human Lymphocyte Biology and Its Application to Humanized Mice. In: Ikezu, T., Gendelman, H. (eds) Neuroimmune Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-44022-4_14

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