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Keratoconus pp 25–41Cite as

Histopathology (from Keratoconus Pathology to Pathogenesis)

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Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

Abstract

Histopathology has long been used to confirm the diagnosis of keratoconus and to determine the extent of disease progression in tissue post-corneal transplant. We examine here how modern advances in histopathology have informed the pathology of the condition and describe how the technique of immunohistochemistry, in particular, has enabled researchers to describe pathology down to the protein and molecular level. This chapter examines how this information has been used to decipher clues towards understanding the pathogenesis of keratoconus.

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Declaration

Trevor Sherwin, Salim Ismail, I-Ping Loh and Jennifer Jane McGhee declare that they have no conflict of interest.

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.

No animal studies were carried out by the authors for this article

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Authors and Affiliations

  1. Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

    Trevor Sherwin B.Sc. (Hons), Ph.D., Salim Ismail B.Sc., M.Sc. (Hons), I-Ping Loh M.Sc. & Jennifer Jane McGhee B.Sc.

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  1. Trevor Sherwin B.Sc. (Hons), Ph.D.
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  2. Salim Ismail B.Sc., M.Sc. (Hons)
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  3. I-Ping Loh M.Sc.
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  4. Jennifer Jane McGhee B.Sc.
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Correspondence to Trevor Sherwin B.Sc. (Hons), Ph.D. .

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Editors and Affiliations

  1. Keratoconus Unit Department of Refractive Surgery, Vissum Alicante, Alicante, Spain

    Jorge L. Alió

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Sherwin, T., Ismail, S., Loh, IP., McGhee, J.J. (2017). Histopathology (from Keratoconus Pathology to Pathogenesis). In: Alió, J. (eds) Keratoconus. Essentials in Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-319-43881-8_4

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  • DOI: https://doi.org/10.1007/978-3-319-43881-8_4

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