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Reproductive Health and Nutrition

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Nutrition and Health in a Developing World

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Abstract

This chapter discusses the relationship between nutritional status and reproductive well-being. It explores the role that nutrition plays during various phases of the reproductive cycle starting from the onset of puberty, to the menstrual cycle, to pregnancy. It also explores the role of nutrition in other aspects of reproductive health such as sexually transmitted infections and reproductive organ cancers. Evidence on clinical interventions involving supplementation is reviewed. Where possible the chapter examines the potential biological pathways of impact from nutrients to the outcome.

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References

  1. UN Economic and Social Council. Framework of actions for the follow-up to the programme of action of the international conference on population and development (ICPD) beyond; 2014.

    Google Scholar 

  2. Elgood C. Tibb-ul-Nabi or medicine of prophet. Osiris; 1962:70, 72, 73, 75–7, 82 Accessible at http://isites.harvard.edu/fs/docs/icb.topic1404975.files/Unit%203/Elgood_Tibb-ul-Nabbi%20or%20Medicine%20of%20the%20Prophet%20-%201962.pdf.

  3. Farquhar C. Introduction and history of polycystic ovary syndrome. In: Kovacs GT, Norman R, editors. Polycystic ovary syndrome. Cambridge: Cambridge University Press; 22 Feb 2007. p. 4. ISBN 9781139462037. Accessible at http://books.google.com/books?id=bpn1u9hziVgC&pg=PA4#v=onepage&q&f=false.

  4. Vandereycken W, van Deth R. A tribute to Lasègue’s description of anorexia nervosa (1873), with completion of its English translation. Br J Psychiatry. 1990;157:902–8.

    Article  CAS  PubMed  Google Scholar 

  5. Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child. 1969;44(235):291–303.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Connor N. Impact of fetal and neonatal malnutrition on the onset of puberty and associated noncommunicable disease risks. Adolesc Health Med Ther. 2011;2:15–25. doi:10.2147/AHMT.S10147. Accessed at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926776/.

  7. Ahmed ML, Ong KK, Dunger DB. Childhood obesity and the timing of puberty. Trends Endocrinol Metab. 2009;20(5):237–42.

    Article  CAS  PubMed  Google Scholar 

  8. Juul A, Teilmann G, Scheike T, Hertel NT, Holm K, Laursen EM, Main KM, Skakkebaek NE. Pubertal development in Danish children: comparison of recent European and US data. Int J Androl. 2006;29(1):247–55; discussion 286–90.

    Google Scholar 

  9. Semiz S, Kurt F, Kurt DT, Zencir M, Sevinç O. Pubertal development of Turkish children. J Pediatr Endocrinol Metab. 2008;21(10):951–61.

    Article  PubMed  Google Scholar 

  10. Kaplowitz PB. Link between body fat and the timing of puberty. Pediatrics. 2008;121(Suppl 3):S208–17. doi:10.1542/peds.2007-1813F.

    Article  PubMed  Google Scholar 

  11. Villamor E, Marin C, Mora-Plazas M, Baylin A. Vitamin D deficiency and age at menarche: a prospective study. Am J Clin Nutr. 2011;94:1020–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Poyastro PA, Thornton LM, Plotonicov KH, et al. Patterns of menstrual disturbance in eating disorders. Int J Eat Disord. 2007;40(5):424–34.

    Google Scholar 

  13. Hoffman ER, Zerwas SC, Bulik CM. Reproductive issues in anorexia nervosa. Expert Rev Obstet Gynecol. 2011;6(4):403–14. doi:10.1586/eog.11.31.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Nattiv A, Loucks AB, Manore MM, Sanborn CF, Sundgot-Borgen J, Warren MP. American College of Sports Medicine. American College of Sports Medicine position stand. The female athlete triad. Med Sci Sports Exerc. 2007;39(10):1867–82.

    Article  PubMed  Google Scholar 

  15. Fritz MA, Speroff L. Female infertility. In: Gynecologic Clinical, editor. Endocrinology and infertility. 8th ed. Philadelphia: Lippincott Williams and Wilkins; 2011. p. 1137–90.

    Google Scholar 

  16. Yogev Y, Catalano PM. Pregnancy and obesity. Obstet Gynecol Clin North Am. 2009;36(2):285–300.

    Article  PubMed  Google Scholar 

  17. Canning S, Waterman M, Dye L. Dietary supplements and herbal remedies for premenstrual syndrome (PMS): a systematic research review of the evidence for their efficacy. J Reprod Infant Psychol. 2006;24(4):363–78.

    Article  Google Scholar 

  18. Loudon I. Maternal mortality in the past and its relevance to developing countries today. Am J Clin Nutr. 2000;72(1 Suppl.):241s–6s.

    CAS  PubMed  Google Scholar 

  19. World Health Organization. International classification of diseases and related health problems, tenth revision, vol. 1. Geneva, Switzerland: World Health Organization; 1992.

    Google Scholar 

  20. National Research Council. The consequences of maternal morbidity and maternal mortality: report of a workshop. Washington, DC: The National Academies Press; 2000.

    Google Scholar 

  21. World Health Organization. Trends in maternal mortality: 1990 to 2013. Estimates by WHO, UNICEF, UNFPA, The World Bank and the United Nations Population Division; 2014.

    Google Scholar 

  22. Rush D. Nutrition and maternal mortality in the developing world. Am J Clin Nutr. 2000;72(suppl):212S–40S.

    CAS  PubMed  Google Scholar 

  23. World Health Organization. Balanced energy and protein supplementation during pregnancy; 2014. http://www.who.int/elena/titles/energy_protein_pregnancy/en/.

  24. Wells JCK. Maternal capital and the metabolic ghetto: an evolutionary perspective on the transgenerational basis of health inequalities. Am J Hum Biol. 2010;22:1–17. doi:10.1002/ajhb.20994.

    Article  PubMed  Google Scholar 

  25. Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ. 2005;330:565.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Ota E, Tobe-Gai R, Mori R, Farrar D. Antenatal dietary advice and supplementation to increase energy and protein intake. Cochrane Database Syst Rev. 2012;(9), Art. No.: CD000032. doi:10.1002/14651858.CD000032.pub2.

  27. Kramer MS, Kakuma R. Energy and protein intake in pregnancy. Cochrane Database Syst Rev. 2007;(4), Art. No.: CD000032. doi:10.1002/14651858.CD00003.

  28. Faisel H, Pitroff R. Vitamin A and causes of maternal mortality: association and biological plausibility. Public Health Nutr. 2000;3:321–7.

    Article  CAS  PubMed  Google Scholar 

  29. Middleton PF, Lassi ZS, son Tran T, Bhutta Z, Bubner TK, Flenady V, Crowther CA. Nutrition interventions and programs for reducing mortality and morbidity in pregnant and lactating women and women of reproductive age: a systematic review. ARCH. 2013.

    Google Scholar 

  30. Ahmed F, Khan MR, Jackson AA. Concomitant supplemental vitamin A enhances the response to weekly supplemental iron and folic acid in anemic teenagers in urban Bangladesh. Am J Clin Nutr. 2001;74:105–15.

    Google Scholar 

  31. Kontic-Vucinic O, Terzic M, Radunovic N. The role of antioxidant vitamins in hypertensive disorders of pregnancy. J Perinat Med. 2008;36:282–90.

    Article  CAS  PubMed  Google Scholar 

  32. Al-Gubory KH, Fowler PA, Garrel C. The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int J Biochem Cell Biol. 2010;42:1634–50.

    Article  CAS  PubMed  Google Scholar 

  33. Conde-Agudelo A, Romero R, Kusanovic JP, Hassan SS. Supplementation with vitamins C and E during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: a systematic review and metaanalysis. Am J Obstet Gynecol. 2011;204:503.e1–12.

    Google Scholar 

  34. World Health Organization. Vitamin and mineral requirements in human nutrition, vol 2. Geneva; 2004.

    Google Scholar 

  35. Grundman M, von Versen-Höynck F. Vitamin D—roles in women’s reproductive health? Reprod Biol Endocrinol. 2011;9:146.

    Article  Google Scholar 

  36. Mehta S, Giovannucci E, Mugusi FM, Spiegelman D, Aboud S, Hertzmark E. Vitamin D status of HIV-infected women and its association with HIV disease progression, anemia and mortality. PLoS ONE. 2010;5(1):e8770.

    Article  PubMed  PubMed Central  Google Scholar 

  37. De-Regil LM, Palacios C, Ansary A, Kulier R, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst. Rev. 2012;(2), Art. No.: CD008873. doi:10.1002/14651858.CD008873.pub2.

  38. Hofmeyr GJ, Lawrie TA, Atallah ÁN, Duley L, Torloni MR. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev. 2014;(6), Art. No.: CD001059. doi:10.1002/14651858.CD001059.pub4.

  39. Lassi ZS, Salam RA, Haider BA, Bhutta ZA. Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes. Cochrane Database Syst Rev. 2013;(3), Art. No.: CD006896. doi:10.1002/14651858.CD006896.pub2.

  40. Charmel R. Cobalamin (Vitamin B12). In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, editors. Modern nutrition in health and disease. 10th ed. USA: Lippincott Williams & Wilkins; 2006. p. 482–97.

    Google Scholar 

  41. Rush D. Nutrition and maternal mortality in the developing world. Am J Clin Nutr. 2000;72(suppl):212S–40S.

    CAS  PubMed  Google Scholar 

  42. Peña-Rosas JP, De-Regil LM, Dowswell T, Viteri FE. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2012;(12), Art. No.: CD004736. doi:10.1002/14651858.CD004736.pub4).

  43. World Health Organization. Prevention of iron deficiency anaemia in adolescents: role of weekly iron and folic acid supplementation. Vol. SEA-CAH-02. New Delhi: WHO SEA; 2011.

    Google Scholar 

  44. Berti PR, Mildon A, Siekmans K, Main B, MacDonald C. An adequacy evaluation of a 10-year, four-country nutrition and health programme. Int J Epidemiol. 2010;39:613–29.

    Article  PubMed  PubMed Central  Google Scholar 

  45. World Health Organization (Western Pacific Region). Weekly iron and folic acid supplementation programmes for women of reproductive age: an analysis of best programme practices. Geneva: WHO; 2011.

    Google Scholar 

  46. Pizarro CF, Davidson L. Anemia during pregnancy: influence of mild/moderate/severe anemia on pregnancy outcome. Nutrire: rev. Soc. Bras. Alim Nutr J Brazilian Soc Food Nutr. 2003;25:153–80.

    Google Scholar 

  47. World Health Organization. The global prevalence of anaemia in 2011. Geneva: World Health Organization; 2015.

    Google Scholar 

  48. Gamble CL, Ekwaru JP, ter Kuile FO. Insecticide-treated nets for preventing malaria in pregnancy. Cochrane Database Syst Rev. 2006;(2), Art. No.: CD003755. doi:10.1002/14651858.CD003755.pub2.

  49. McClure EM, Goldenberg RL, Dent AE, Meshnick SR. A systematic review of the impact of malaria prevention in pregnancy on low birth weight and maternal anemia. Int J Gynecol Obstet. 2013;121:103–9. doi:10.1016/j.ijgo.2012.12.014.

    Article  Google Scholar 

  50. Brooker S, Hotez PJ, Bundy DAP. Hookworm-related anaemia among pregnant women: a systematic review. PLoS Negl Trop Dis. 2008;2(9):e291. doi:10.1371/journal.pntd.0000291.

    Article  PubMed  PubMed Central  Google Scholar 

  51. King JC, Cousins RJ. Zinc. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, editors. Modern nutrition in health and disease. 10th ed. Philadelphia, PA.

    Google Scholar 

  52. Caulfield LE, Zavaleta N, Shankar AH, Merialdi M. Potential contribution of maternal zinc supplementation during pregnancy to maternal and child survival.

    Google Scholar 

  53. Mori R, Ota E, Middleton P, Tobe-Gai R, Mahomed K, Bhutta ZA. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database Syst Rev. 2012;(7), Art. No.: CD000230. doi:10.1002/14651858.CD000230.pub4.

  54. Makrides M, Crosby DD, Bain E, Crowther CA. Magnesium supplementation in pregnancy. Cochrane Database Syst Rev. 2014;(4), Art. No.: CD000937. doi:10.1002/14651858.CD000937.pub2.

  55. Jain S, Sharma P, Kulshreshtha S, Mohan G, Singh S. The role of calcium, magnesium and zinc in pre-eclampsia. Biol Trace Elem Res. 2010;133:162–70.

    Article  CAS  PubMed  Google Scholar 

  56. Obican SG. Jahnke GD. Soldin OP. Scialli AR. Teratology public affairs committee position paper: iodine deficiency in pregnancy. Birth Defects Res (Part A): Clin Mol Teratol. 2012;94:677–82.

    Google Scholar 

  57. Zimmermann MB. The effects of iodine deficiency in pregnancy and infancy. Paediatr Perinat Epidemiol. 2012;26:108–17. doi:10.1111/j.1365-3016.2012.01275.x.

    Article  PubMed  Google Scholar 

  58. Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database of Syst Rev. 2015;(11), Art. No.: CD004905. doi:10.1002/14651858.CD004905.pub4.

  59. Fall CH, Fisher DJ, Osmond C, Margetts BM. Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on birth size and length of gestation. Food Nutr Bull. 2009;30(4 Suppl):S533–46.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Fritz MA, Speroff L. Female infertility. In: Gynecologic Clinical, editor. Endocrinology and infertility. 8th ed. Philadelphia: Lippincott Williams and Wilkins; 2011. p. 1137–90.

    Google Scholar 

  61. Aviram A, Hod M, Yogev Y. Maternal obesity: Implications for pregnancy outcome and longterm risks—a link to maternal nutrition. The impact of obesity and maternal nutrition on short-term pregnancy outcome and long-term child health.

    Google Scholar 

  62. Mehendale SM, Shepherd ME, Brookmeyer RS, Semba RD, Divekar AD, Gangakhedar RR, Joshi S, Paranjape RS, Risbud AR, Gadkari DA, Bollinger RD. Low carotenoid concentrations and risk of HIV seroconversion in Pune, India. J Acquir Immune Defic Syndr. 2001;26:352–9.

    Article  CAS  PubMed  Google Scholar 

  63. Baeten JM, McClelland RS, Corey L, Overbaugh J, Lavreys L, Richardson BA, Wald A, Mandaliya K, Bwayo JJ, Kreiss JK. Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial. J Infect Dis. 2004;189:1466–71.

    Article  CAS  PubMed  Google Scholar 

  64. International Agency for Research on Cancer (IARC). GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. Accessible at http://globocan.iarc.fr/Pages/fact_sheets_population.aspx. 19 Sep 2014.

  65. van den Brandt PA, Siegelman D, Yaun SS, et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol. 2000;152:514–27.

    Article  PubMed  Google Scholar 

  66. International Agency for Research on Cancer (IARC). Weight and weight control: breast cancer. In: IARC handbooks of cancer prevention. Weight control and physical activity. Lyon (France): IARC Press; 2002. p. 95–112.

    Google Scholar 

  67. Calle EE, Rodriguez C, Walker-Thurmonnd K, Thun MJ. Overweight, obesity and mortality from cancer in a prospectively studies cohort of U.S. adults. N Engl J Med. 2003;348(17):1625–38.

    Article  PubMed  Google Scholar 

  68. Rapp K, Schroeder J, Klenk J, et al. Obesity and incidence of cancer: a large cohort study of over 145 000 adults in Austria. Br J Cancer. 2005;93:1062–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Wang D, Vélez de-la-Paz OI, Zhai JX, Liu DW. Serum 25-hydroxy vitamin D and breast cancer risk: a meta-analysis of prospective studies. Tumour Biol. 2013;34(6):3509–17. doi:10.1007/s13277-013-0929-2 (Epub 2013 Jun 27).

  70. Misotti AM, Gnagnarella P. Vitamin supplement consumption and breast cancer risk: a review. Ecancermedicalscience. 2013;7:365. doi:10.3332/ecancer.2013.365.

    PubMed  PubMed Central  Google Scholar 

  71. Poole EM, Shu X, Chen WY. Post-diagnosis supplement use and breast cancer prognosis in the After Breast Cancer Pooling Project. Breast Cancer Res Treat. 2013;139(2):529–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Zhang X, Dai B, Zhang B, Vitamin ZW. A and risk of cervical cancer: a meta-analysis. Gynecol Oncol. 2012;124:366–73.

    Article  CAS  PubMed  Google Scholar 

  73. Olsen CM, Green AC, Whiteman DC, Sadeghi S, Kolahdooz F, Webb PM. Obesity and the risk of epithelial ovarian cancer: A systematic review and meta-analysis. Eur J Cancer. 2007;43(4):690–709.

    Article  PubMed  Google Scholar 

  74. Nagle CM, Kolandooz F, Ibiebele TI, et al. Carbohydrate intake, glycemic load, glycemic index and risk of ovarian cancer. Ann Oncol. 2011;22(6):1332–8. doi:10.1093/annonc/mdq595.

  75. Webb PM, Ibiebele TI, Hughes MC, et al. Folate and related microonutrients, folate-metabolising genes and risk of ovarian cancer. Eur J Clin Nutr. 2011;65(10):1133–40. doi:10.1038/ejcn.2011.99.

    Article  CAS  PubMed  Google Scholar 

  76. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray, F. GLOBOCAN 2012 v1.1, Cancer incidence and mortality worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2014. Available from: http://globocan.iarc.fr. Accessed on 16 Jan 2015.

  77. Roswall N, Larrsen SB, Friis S, et al. Micronutrient intake and risk of prostate cancer in a cohort of middle-aged Danish men. Cancer Causes Control. 2013;24(6):1129–35. doi:10.1007/s10552-013-0190-4.

  78. Lippman SM, Klein EA, Goodman PJ. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E Cancer prevention trial (SELECT). JAMA. 2009;301(1):39–51. doi:10.1001/jama.2008.864.

    Article  CAS  PubMed  Google Scholar 

  79. Lawson KA, Wright ME, Subar A, et al. Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and health Study. J Natl Cancer Inst. 2007;99(10):754–64.

    Article  CAS  PubMed  Google Scholar 

  80. Itsiopoulos C, Hodge A, Kaimakamis M. Can the Mediterranean diet prevent prostate cancer? Mol Nutr Food Res. 2009;53:227–39. doi:10.1002/mnfr.200800207.

    Article  CAS  PubMed  Google Scholar 

  81. Raimondi S, Mabrouk JB, Shatensteiin B, Maisonneuve P, Ghadirian P. Diet and prostate cancer risk with specific focus on dairy products and dietary calcium: a case-control study. Prostate. 2010;70(10):1054–65. doi:10.1002/pros.21139.

    Article  CAS  PubMed  Google Scholar 

  82. Ahn J, Albanes D, Peters U, et al. Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev. 2007;16:2623–30.

    Article  CAS  PubMed  Google Scholar 

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Chalasani, S., Ortayli, N. (2017). Reproductive Health and Nutrition. In: de Pee, S., Taren, D., Bloem, M. (eds) Nutrition and Health in a Developing World . Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-43739-2_21

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