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Microbiology, Genomics, and Population Structure

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Advances in Understanding Kingella kingae

Part of the book series: SpringerBriefs in Immunology ((BRIEFSIMMUN))

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Abstract

The development of improved detection methods has established that Kingella kingae is an important pediatric pathogen and the most common etiology of joint and bone infections among children between the ages of 6 and 36 months. K. kingae is a β-hemolytic gram-negative coccobacillus and a normal component of the oropharyngeal microbiota in young children. Oropharyngeal colonization is the source of person-to-person transmission and invasion of the bloodstream, frequently in the context of a concomitant oral or respiratory viral infection. Although K. kingae is naturally competent, the organism exhibits remarkable clonality. Certain clonal groups are associated primarily with oropharyngeal colonization (carriage), while others are associated with bacteremia, osteoarticular infections, or endocarditis. Some clones have a restricted geographic distribution, and others are a common cause of invasive K. kingae disease worldwide.

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Acknowledgments

We thank Dr. Romain Basmaci for constructing the minimum spanning tree in Fig. 2a, b.

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Authors and Affiliations

  1. Sorbonne Paris Cité, Université Paris Diderot, Paris, France

    Stéphane Bonacorsi & Philippe Bidet

  2. AP-HP, Laboratoire de Microbiologie, Hôpital Robert-Debré, Paris, France

    Stéphane Bonacorsi & Philippe Bidet

  3. Clinical Microbiology Laboratory, Soroka University Medical Center, Ben-Gurion University of the Negev, 84101, Beer-Sheva, Israel

    Pablo Yagupsky

Authors
  1. Stéphane Bonacorsi
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  2. Philippe Bidet
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  3. Pablo Yagupsky
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Correspondence to Pablo Yagupsky .

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Editors and Affiliations

  1. Physician-in-Chief, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Joseph W. St. Geme, III

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Bonacorsi, S., Bidet, P., Yagupsky, P. (2016). Microbiology, Genomics, and Population Structure. In: St. Geme, III, J. (eds) Advances in Understanding Kingella kingae. SpringerBriefs in Immunology. Springer, Cham. https://doi.org/10.1007/978-3-319-43729-3_1

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