Pharmacology of Local Anaesthetics



Local anaesthetics are the most commonly used pharmaceuticals in dentistry. When used at the recommended doses, they interfere reversibly with the generation of the action potential and with cellular impulse conduction by blockading the sodium channels in the nerve cell. This results in a local insensibility to pain stimuli.


Sodium Channel Tertiary Amine Dental Treatment Lipid Solubility Amino Alcohol 
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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Vrije Universiteit Medical Centre, Department of PharmacologyAmsterdamThe Netherlands

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