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Intra-arterial Delivery of Chemotherapeutic Agents

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Pediatric Vascular Neurosurgery

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Abstract

Intra-arterial chemotherapy (IAC) has been described in the treatment of retinoblastoma [1–3], sarcoma [4, 5], and malignant glioma [6, 7]. Intra-arterial chemotherapy (IAC) in these settings has generally been considered adjuvant therapy along with systemic chemotherapy, surgical resection, and/or radiation therapy. IAC is appealing given the potential to limit systemic toxicity from chemotherapeutic agents while increasing the concentration in areas of active malignancy. Within the central nervous system, the blood brain barrier (BBB) has proven to be a hurdle to the delivery of chemotherapy agents with various protocols described to help breakdown the BBB to facilitate chemotherapy delivery [8]. Within the pediatric population, IAC for the treatment of retinoblastoma (Rb) has become well studied with a good safety profile and efficacy.

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Authors and Affiliations

  1. Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA

    Lucy L. He MD

  2. Brain Aneurysm Institute, Neurosurgery Service, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Ajith J. Thomas MD & Christopher S. Ogilvy MD

Authors
  1. Lucy L. He MD
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  2. Ajith J. Thomas MD
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  3. Christopher S. Ogilvy MD
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Correspondence to Lucy L. He MD .

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Editors and Affiliations

  1. Department of Neurosurgery, Methodist Neurological Institute, Houston, Texas, USA

    Abhishek Agrawal

  2. Department of Neurosurgery, Methodist Neurological Institute, Houston, Texas, USA

    Gavin Britz

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He, L.L., Thomas, A.J., Ogilvy, C.S. (2016). Intra-arterial Delivery of Chemotherapeutic Agents. In: Agrawal, A., Britz, G. (eds) Pediatric Vascular Neurosurgery. Springer, Cham. https://doi.org/10.1007/978-3-319-43636-4_21

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  • DOI: https://doi.org/10.1007/978-3-319-43636-4_21

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  • Online ISBN: 978-3-319-43636-4

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