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Histiocytoses and Malignancy

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Therapy in Pediatric Dermatology

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Abstract

Histiocytes are tissue macrophages or dendritic cells derived from the bone marrow. An abnormal proliferation of histiocytes is the defining features of the histiocytoses. Of these, the most well known is likely Langerhans cell histiocytosis, as it often presents in infancy and can mimic other more common infantile conditions such as diaper dermatitis and seborrheic dermatitis. Juvenile xanthogranuloma is the most common non-Langerhan cell histiocytosis, presenting typically as an erythematous, yellow or orange papule. The other histiocytoses are quite rare. Some, such as benign cephalic histiocytosis, are predominantly seen in children, whereas others, such as xanthoma disseminatum and multicentric reticulohistiocytosis, are predominantly seen in adults.

Malignant skin diseases are rare in the pediatric population. The two discussed in this chapter are leukemia cutis, which is typically a manifestation of an internal malignancy, and cutaneous T-cell lymphoma, the most common form of cutaneous lymphoma in childhood.

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Author information

Authors and Affiliations

  1. Department of Dermatology, University of Washington Seattle Children’s Hospital, 4800 Sand Point Way NE, Seattle, WA, 98105, USA

    Deepti Gupta

  2. Department of Dermatology, Stanford University School of Medicine, 450 Broadway Street, Pavilion C, 2nd Floor, Redwood City, CA, 94063, USA

    Albert S. Chiou

  3. Dermatology and Pediatrics, Stanford University, 700 Welch Road, Suite 301, Palo Alto, CA, 94304, USA

    Ann L. Marqueling

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  1. Deepti Gupta
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  2. Albert S. Chiou
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  3. Ann L. Marqueling
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Correspondence to Deepti Gupta .

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Editors and Affiliations

  1. Stanford University School of Medicine, Stanford, California, USA

    Joyce M.C. Teng

  2. Stanford University School of Medicine, Stanford, California, USA

    Ann L. Marqueling

  3. Pediatric Dermatology, Joe DiMaggio Children’s Hospital, Hollywood, Florida, USA

    Latanya T. Benjamin

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Gupta, D., Chiou, A.S., Marqueling, A.L. (2017). Histiocytoses and Malignancy. In: Teng, J., Marqueling, A., Benjamin, L. (eds) Therapy in Pediatric Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-43630-2_10

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