DNA Methylation and Gene Regulation in Honeybees: From Genome-Wide Analyses to Obligatory Epialleles

  • Laura Wedd
  • Ryszard MaleszkaEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 945)


In contrast to heavily methylated mammalian genomes, invertebrate genomes are only sparsely methylated in a ‘mosaic’ fashion with the majority of methylated CpG dinucleotides found across gene bodies. Importantly, this gene body methylation is frequently associated with active transcription, and studies in the honeybee have shown that there are strong links between gene body methylation and alternative splicing. Additional work also highlights that obligatory methylated epialleles influence transcriptional changes in a context-specific manner. Here we discuss the current knowledge in this emerging field and highlight both similarities and differences between DNA methylation systems in mammals and invertebrates. Finally, we argue that the relationship between genetic variation, differential DNA methylation, other epigenetic modifications and the transcriptome must be further explored to fully understand the role of DNA methylation in converting genomic sequences into phenotypes.


Anaplastic Lymphoma Kinase Transcriptional Change Royal Jelly Gene Body Methylation Invertebrate Genome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.







Anaplastic lymphoma kinase


Cytosine and guanine dinucleotide separated by one phosphate in DNA


CCCTC-binding protein


DNA-binding protein


DNA methyltransferase


Lysosomal alpha-mannosidase


Methyl-CpG-binding factor


microRNA small non-coding RNA of about 22 nucleotides


messenger RNA


Post-translational modification


RNA-directed DNA methylation system


Ten-eleven translocation enzyme


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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Research School of BiologyThe Australian National UniversityCanberraAustralia

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