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Follicular and Hürthle Cell Carcinoma

  • Naris NilubolEmail author
  • Xavier Keutgen
  • Electron Kebebew
Chapter

Abstract

Follicular neoplasms are uncommon thyroid tumors with several histologic subtypes, such as follicular adenoma, Hürthle cell adenoma, and minimally invasive and widely invasive follicular and Hürthle thyroid carcinoma. The diagnosis of a malignant follicular thyroid tumor is based on the presence of capsular and/or vascular invasion on histologic examination. In this chapter, we review the clinical, radiographic, and pathological characteristics of follicular and Hürthle cell carcinoma. The role of molecular diagnostic assays to distinguish benign tumors from malignant counterparts is still limited. The difference in tumor behavior between follicular and Hürthle cell carcinoma is discussed. Although controversies related to the optimal management of these tumors remain due to their rarity, this chapter includes the management of minimally invasive follicular thyroid carcinoma based on clinicopathological risk factors. We summarize the treatments of widely invasive follicular and Hürthle cell carcinoma, including the role of lymphadenectomy in treating these tumors. Postoperative management methods, such as the use of radioactive iodine ablation, thyroid-stimulating hormone (TSH) suppression therapy in follicular and Hürthle cell carcinoma, as well as surveillance for recurrent disease, are included. Lastly, we provide the summary of the outcome that shows shorter survival in patients with Hürthle cell carcinoma, as compared with those with follicular and papillary thyroid carcinoma.

Keywords

Follicular thyroid carcinoma Hürthle cell carcinoma Minimally invasive follicular thyroid carcinoma Widely invasive follicular thyroid carcinoma Follicular neoplasm Hürthle cell neoplasm 

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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Naris Nilubol
    • 1
    Email author
  • Xavier Keutgen
    • 2
  • Electron Kebebew
    • 3
  1. 1.Endocrine Oncology BranchNational Cancer InstituteMarylandUSA
  2. 2.Department of SurgeryRush University Medical CenterChicagoUSA
  3. 3.Endocrine Oncology BranchNational Cancer Institute, National Institute of HealthBethesdaUSA

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