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AMPK/Mitochondria in Metabolic Diseases

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AMP-activated Protein Kinase

Part of the book series: Experientia Supplementum ((EXS,volume 107))

Abstract

The obtaining of nutrients is the most important task in our lives. Energy is central to life’s evolutions; this was one of the aspect that induced the selection of the more adaptable and more energetically profitable species. Nowadays things have changed in our modern society. A high proportion of people has access to plenty amount of food and the obesity appear as one of the pathological characteristics of our society. Energy is obtained essentially in the mitochondria with the transfer of protons across the inner membrane that produce ATP. The exactly regulation of the synthesis and degradation of ATP (ATP ↔ ADP + phosphate) is essential to all form of life. This task is performed by the 5' adenosine monophosphate-activated protein kinase (AMPK). mtDNA is highly exposed to oxidative damage and could play a central role in human health and disease. This high potential rate of abnormalities is controlled by one of the most complex mechanism: the autophagy. AMPK appears to be the key cellular energy sensor involved in multiple cellular mechanisms and is essential to have a good metabolic homeostasis to face all the aggression and start the inflammatory reaction. Therefore its disturbances have been related with multiple diseases. Recent findings support the role of AMPK in inflammation and immunity such as Metabolic Syndrome, Obesity and Diabetes. All these Metabolic Disorders are considered pandemics and they need an adequate control and prevention. One important way to achieve it is deepen in the pathogenic mechanisms. Mitochondria and AMPK are the key elements through which it happen, their knowledge and research allow us to a better management. The discovery and use of drugs that can modulate them is imperative to improve our way of manage the metabolic disorders.

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Authors and Affiliations

  1. Department of Oral Medicine and Periodontology, Dental School, University of Seville, C/Avicena s/n, Seville, 41009, Spain

    Pedro Bullon

  2. Departament of Oral Medicine and Periodontology, Ministry of Education, Culture and Sport, c/Avicena s/n, Seville, 41009, Spain

    Fabiola Marin-Aguilar

  3. Departament of Oral Medicine and Periodontology, University of Seville, c/Avicena s/n, Seville, 41009, Spain

    Lourdes Roman-Malo

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Correspondence to Pedro Bullon .

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  1. Oral Medicine Department, Universidad de Sevilla, Sevilla, Spain

    Mario D. Cordero

  2. INSERM U1016 Institut Cochin CNRS UMR 8104, Université Paris Descartes, Paris, France

    Benoit Viollet

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Bullon, P., Marin-Aguilar, F., Roman-Malo, L. (2016). AMPK/Mitochondria in Metabolic Diseases. In: Cordero, M., Viollet, B. (eds) AMP-activated Protein Kinase. Experientia Supplementum, vol 107. Springer, Cham. https://doi.org/10.1007/978-3-319-43589-3_6

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