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AMPK in Yeast: The SNF1 (Sucrose Non-fermenting 1) Protein Kinase Complex

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Book cover AMP-activated Protein Kinase

Part of the book series: Experientia Supplementum ((EXS,volume 107))

Abstract

In yeast, SNF1 protein kinase is the orthologue of mammalian AMPK complex. It is a trimeric complex composed of Snf1 protein kinase (orthologue of AMPKα catalytic subunit), Snf4 (orthologue of AMPKγ regulatory subunit), and a member of the Gal83/Sip1/Sip2 family of proteins (orthologues of AMPKβ subunit) that act as scaffolds and also regulate the subcellular localization of the complex. In this chapter, we review the recent literature on the characteristics of SNF1 complex subunits, the structure and regulation of the activity of the SNF1 complex, its role at the level of transcriptional regulation of relevant target genes and also at the level of posttranslational modification of targeted substrates. We also review the crosstalk of SNF1 complex activity with other key protein kinase pathways such as cAMP–PKA, TORC1, and PAS kinase.

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Abbreviations

AID:

Autoinhibitory domain

ASC:

Association with Snf1 complex

AMPK:

AMP-activated protein kinase

CBS:

Cystathionine-β-synthase domain

CSRE:

Carbon source-responsive element

eIF2α:

Eukaryotic initiation factor 2α

GBD:

Glycogen-binding domain

KD:

Catalytic domain

RD:

Regulatory domain

Snf1:

sucrose non-fermenting 1

TORC1:

Target of rapamycin complex 1

PAS kinase:

Protein kinase with a PAS domain

PKA:

Protein kinase A

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Acknowledgements

This study was supported by grants from the Spanish Ministry of Education and Science SAF2014-54604-C3-1-R and Generalitat Valenciana (PrometeoII/2014/029) to P.S.

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Authors and Affiliations

  1. Instituto de Biomedicina de Valencia, CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER-ISCiii), Jaime Roig 11, 46010, Valencia, Spain

    Pascual Sanz & Rosa Viana

  2. Department of Biotecnología, Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural (ETSIAMN), Universitat Politécnica de Valencia, Valencia, Spain

    Maria Adelaida Garcia-Gimeno

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  1. Pascual Sanz
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  2. Rosa Viana
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  3. Maria Adelaida Garcia-Gimeno
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Correspondence to Pascual Sanz .

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  1. Oral Medicine Department, Universidad de Sevilla, Sevilla, Spain

    Mario D. Cordero

  2. INSERM U1016 Institut Cochin CNRS UMR 8104, Université Paris Descartes, Paris, France

    Benoit Viollet

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© 2016 Springer International Publishing Switzerland

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Sanz, P., Viana, R., Garcia-Gimeno, M.A. (2016). AMPK in Yeast: The SNF1 (Sucrose Non-fermenting 1) Protein Kinase Complex. In: Cordero, M., Viollet, B. (eds) AMP-activated Protein Kinase. Experientia Supplementum, vol 107. Springer, Cham. https://doi.org/10.1007/978-3-319-43589-3_14

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