Skip to main content
SpringerLink
Log in

Variation of HPV Subtypes with Focus on HPV-Infection and Cancer in the Head and Neck Region

  • Chapter
  • First Online:
HPV Infection in Head and Neck Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 206))

Abstract

The human papillomavirus (HPV) comprises a heterogeneous group of double-strand DNA viruses with variable potential to infect human epithelial cells and trigger neoplastic transformation. Its 8 kb genome encodes proteins required for virus replication and self-organized formation of infectious particles but also for early proteins E6 and E7 able to trigger neoplastic transformation. E6 and E7 of high-risk (HR) HPV subtypes can bind to p53 or release E2F and abrogate replication control. Due to variable amino acid sequence (AAS) in the binding sites of E6 and E7 particular HR-HPV variants within subtypes are essentially heterogeneous in efficacy triggering neoplastic transformation and cancer development. This could explain differences in the clinical course of HPV-driven head and neck cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bernard HU, Chan SY, Manos MM, Ong CK, Villa LL, Delius H, Peyton CL, Bauer HM, Wheeler CM (1994) Identification and assessment of known and novel human papillomaviruses by polymerase chain reaction amplification, restriction fragment length polymorphisms, nucleotide sequence, and phylogenetic algorithms. J Infect Dis 170(5):1077–1085

    Article  CAS  PubMed  Google Scholar 

  • Berumen J, Ordoñez RM, Lazcano E, Salmeron J, Galvan SC, Estrada RA, Yunes E, Garcia-Carranca A, Gonzalez-Lira G (2001) Madrigal-de la Campa A. Asian-American variants of human papillomavirus 16 and risk for cervical cancer: a case-control study. J Natl Cancer Inst 93(17):1325–1330

    Article  CAS  PubMed  Google Scholar 

  • Canto MT, Devesa SS (2002) Oral cavity and pharynx cancer incidence rates in the United States, 1975-1998. Oral Oncol 38:610–617

    Article  PubMed  Google Scholar 

  • Casas L, Galvan SC, Ordonez RM, Lopez N, Guido M, Berumen J (1999) Asian-American variants of human papillomavirus type 16 have extensive mutations in the E2 gene and are highly amplified in cervical carcinomas. Int J Cancer 83:449–455

    Article  CAS  PubMed  Google Scholar 

  • Chakrabarti O, Veeraraghavalu K, Tergaonkar V, Liu Y, Androphy EJ, Stanley MA, Krishna S (2004) Human papillomavirus type 16 E6 amino acid 83 variants enhance E6-mediated MAPK signaling and differentially regulate tumorigenesis by notch signaling and oncogenic Ras. J Virol 78(11):5934–5945

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chang YJ, Chen HC, Pan MH, Lee BH, You SL, Lin CY, Chou YC, Hsieh CY, Cheng YJ, Liaw KL, Hsing AW, Schiffman M, Chen CJ, CBCSP-HPV Study Group (2013) Intratypic variants of human papillomavirus type 16 and risk of cervical neoplasia in Taiwan. J Med Virol 85(9):1567–1576. doi:10.1002/jmv.23651

  • Chen AA, Gheit T, Franceschi S, Tommasino M, Clifford GM; IARC HPV variant study group (2015) Human papillomavirus 18 genetic variation and cervical cancer risk worldwide. J Virol 89(20):10680–10687. doi:10.1128/JVI.01747-15

  • Clifford GM, Smith JS, Plummer M, Munoz N, Franceschi S (2003) Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. Br J Cancer 88:63–73

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Emeny RT, Herron JR, Xi LF, Koutsky LA, Kiviat NB, Wheeler CM (1999) Comparison of variant-specific hybridization and single-strand conformational polymorphism methods for detection of mixed human papillomavirus type 16 variant infections. J Clin Microbiol 37(11):3627–3633

    CAS  PubMed  PubMed Central  Google Scholar 

  • Eschle D, Dürst M, ter Meulen J, Luande J, Eberhardt HC, Pawlita M, Gissmann L (1992) Geographical dependence of sequence variation in the E7 gene of human papillomavirus type 16. J Gen Virol 73(Pt7):1829–1832

    Article  CAS  PubMed  Google Scholar 

  • Gillison ML, Koch WM, Capone RB et al (2000) Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92:709–720

    Article  CAS  PubMed  Google Scholar 

  • Hoffmann M, Lohrey C, Hunziker A, Kahn T, Schwarz E (2004) Human papillomavirus type 16 E6 and E7 genotypes in -neck carcinomas. Oral Oncol 40(5):520–524

    Article  CAS  PubMed  Google Scholar 

  • Jackson R, Togtema M, Lambert PF, Zehbe I (2014) Tumourigenesis driven by the human papillomavirus type 16 Asian-American E6 variant in a three-dimensional keratinocyte model. PLoS ONE 9(7):e101540. doi:10.1371/journal.pone.0101540

    Article  PubMed  PubMed Central  Google Scholar 

  • Jiang M, Xi LF, Edelstein ZR, Galloway DA, Olsem GJ, Lin WC, Kiviat NB (2009) Identification of recombinant human papillomavirus type 16 variants. Virology 394(1):8–11. doi:10.1016/j.virol.2009.08.040

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Khalifa YB, Teissier S, Tan MK, Phan QT, Daynac M, Wong WQ, Thierry F (2011) The human papillomavirus E6 oncogene represses a cell adhesion pathway and disrupts focal adhesion through degradation of TAp63beta upon transformation. PLoS Pathog 7:e1002256. doi:10.1371/journal.ppat.1002256

    Article  PubMed  PubMed Central  Google Scholar 

  • Klussmann JP, Preuss SF, Speel EJ (2009) Human papillomavirus and cancer of the oropharynx. Molecular interaction and clinical implications. HNO 57(2):113–122. doi:10.1007/s00106-008-1867-y

    Article  CAS  PubMed  Google Scholar 

  • Kreimer AR, Clifford GM, Boyle P, Franceschi S (2005) Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomark Prev 14:467–475

    Article  CAS  Google Scholar 

  • Lavezzo E, Masi G, Toppo S, Franchin E, Gazzola V, Sinigaglia A, Masiero S, Trevisan M, Pagni S, Palù G, Barzon L (2016) Characterization of intra-type variants of oncogenic human papillomaviruses by next-generation deep sequencing of the E6/E7 region. Viruses 8(3). pii: E79. doi:10.3390/v8030079

  • McLaughlin-Drubin ME, Crum CP, Münger K (2011) Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming. Proc Natl Acad Sci USA 108(5):2130–2135. doi:10.1073/pnas.1009933108

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McLaughlin-Drubin ME, Meyers J, Munger K (2012) Cancer associated human papillomaviruses. Curr Opin Virol 2(4):459–466. doi:10.1016/j.coviro.2012.05.004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mosmann JP, Monetti MS, Frutos MC, Kiguen AX, Venezuela RF, Cuffini CG (2015) Mutation detection of E6 and LCR genes from HPV 16 associated with carcinogenesis. Asian Pac J Cancer Prev 16(3):1151–1157

    Article  PubMed  Google Scholar 

  • Muñoz N, Bosch FX, de Sanjosé S, Herrero R, Castellsagué X, Shah KV, Snijders PJ, Meijer CJ (2003) International agency for research on cancer multicenter cervical cancer study group. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348(6):518–527

    Google Scholar 

  • Niccoli S, Abraham S, Richard C, Zehbe I (2012) The Asian-American E6 variant protein of human papillomavirus 16 alone is sufficient to promote immortalization, transformation, and migration of primary human foreskin keratinocytes. J Virol 86:12384–12396

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pande S, Jain N, Prusty BK, Bhambhani S, Gupta S, Sharma R, Batra S, Das BC (2008) Human Papillomavirus type 16 variant analysis of E6, E7, and L1 genes and long control region in biopsy samples from cervical cancer patients in north India. J Clin Microbiol 46(3):1060–1066. doi:10.1128/JCM.02202-07

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rampias T, Boutati E, Pectasides E, Sasaki C, Kountourakis P, Weinberger P, Psyrri A (2010) Activation of Wnt signaling pathway by human papillomavirus E6 and E7 oncogenes in HPV16-positive oropharyngeal squamous carcinoma cells. Mol Cancer Res 8(3):433–443. doi:10.1158/1541-7786.MCR-09-0345

    Article  CAS  PubMed  Google Scholar 

  • Schiffman M, Rodriguez AC, Chen Z, Wacholder S, Herrero R, Hildesheim A, Desalle R, Befano B, Yu K, Safaeian M, Sherman ME, Morales J, Guillen D, Alfaro M, Hutchinson M, Solomon D, Castle PE, Burk RD (2010) A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia. Cancer Res 70(8):3159–3169. doi:10.1158/0008-5472.CAN-09-4179

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Smith B, Chen Z, Reimers L, van Doorslaer K, Schiffman M, Desalle R, Herrero R, Yu K, Wacholder S, Wang T, Burk RD (2011) Sequence imputation of HPV16 genomes for genetic association studies. PLoS ONE 6(6):e21375. doi:10.1371/journal.pone.0021375

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xi LF, Koutsky LA, Galloway DA, Kuypers J, Hughes JP, Wheeler CM, Holmes KK, Kiviat NB (1997) Genomic variation of human papillomavirus type 16 and risk for high grade cervical intraepithelial neoplasia. J Natl Cancer Inst 89(11):796–802

    Article  CAS  PubMed  Google Scholar 

  • Yamada T, Wheeler CM, Halpern AL, Stewart AC, Hildesheim A, Jenison SA (1995) Human papillomavirus type 16 variant lineages in United States populations characterized by nucleotide sequence analysis of the E6, L2, and L1 coding segments. J Virol 69(12):7743–7753

    CAS  PubMed  PubMed Central  Google Scholar 

  • Yamada T, Manos MM, Peto J, Greer CE, Munoz N, Bosch FX, Wheeler CM (1997) Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspective. J Virol 71(3):2463–2472

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zehbe I, Wilander E, Delius H, Tommasino M (1998) Human papillomavirus 16 E6 variants are more prevalent in invasive cervical carcinoma than the prototype. Cancer Res 58(4):829–833

    CAS  PubMed  Google Scholar 

  • Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Dürr P (1999) Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein. Proc Natl Acad Sci USA 96(4):1291–1296

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

Thanks to all my colleagues and collaborators in the Universities of Leipzig, Gießen, Poznan, Milano, and Heidelberg, the funders of our research, and especially all participating patients and their families.

Author information

Authors and Affiliations

  1. ENT-Research Laboratory, Clinic of Otolaryngology, Head and Neck Surgery and Department of Head Medicine and Oral Health, University of Leipzig, Liebigstr. 21, 04103, Leipzig, Germany

    Gunnar Wichmann

Authors
  1. Gunnar Wichmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gunnar Wichmann .

Editor information

Editors and Affiliations

  1. Department of Head and Neck Surgery, Poznan University of Medical Sciences, The Greater Poland Cancer Centre, Poznań, Poland

    Wojciech Golusiński

  2. Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center/Cancer Center Amsterdam, Amsterdam, The Netherlands

    C. René Leemans

  3. Dept. of Head Medicine and Oral Health, University of Leipzig Clinic of Otolaryngology, Leipzig, Germany

    Andreas Dietz

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Wichmann, G. (2017). Variation of HPV Subtypes with Focus on HPV-Infection and Cancer in the Head and Neck Region. In: Golusiński, W., Leemans, C., Dietz, A. (eds) HPV Infection in Head and Neck Cancer. Recent Results in Cancer Research, vol 206. Springer, Cham. https://doi.org/10.1007/978-3-319-43580-0_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-43580-0_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-43578-7

  • Online ISBN: 978-3-319-43580-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation