Skip to main content
SpringerLink
Log in
Book cover

HPV Infection in Head and Neck Cancer pp 257–267Cite as

Vaccination Expectations in HNSCC

  • Chapter
  • First Online:

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 206))

Abstract

HPV-associated head and neck squamous cell carcinoma (HNSCC), more specifically the incidence of oropharyngeal cancer, is dramatically increasing in industrialized countries. According to what has been learned from anogenital vaccination programs, there are reasons to believe that current human papillomavirus (HPV) vaccinations may be potentially effective also against HNSCC. However, before specific results on HNSCC are available, one must keep in mind that carcinogenesis in the head and neck region may differ from that of the anogenital tract. Furthermore, the current evidence supports the view that HPV infection is much more complex than simply a sexually transmitted disease. HPV is present in the semen, placenta and in the newborns, and these infections of the newborns create cell-mediated immunity (CMI) against HPV, including the T memory cells. Acquisition of HPV infection in early life will rise new series of questions in the field of HPV vaccination.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Aboqunrin S, Di Tanna GL, Keeping S, Carroll S, Iheanacho I (2014) Prevalence of human papillomavirus in head and neck cancers in European populations: a meta-analysis. BMC Cancer 14:968

    Google Scholar 

  • Anderson KS, Gerber JE, D’Souza G, Pai SI, Cheng JN, Alam R, Kesiraju S, Chowell D, Gross ND, Haddad R, Gillison ML, Posner M (2015) Biologic predictors of serologic responses to HPV in oropharyngeal cancer: the HOTSPOT study. Oral Oncol 51(8):751–758

    Article  PubMed  PubMed Central  Google Scholar 

  • Beachler DC, Kreimer AR, Schiffman M, Herrero R, Wacholder R, Rodriguez AC, Lowy DR, Porras C, Schiller JT, Quint Q, Jimenez S, Safaeian M, Struijk L, Schussler J, HIlderheim A, Gonzalez P, Costa Rica HPV Vaccine Trial (CVT) Group (2015) Multisite HPV16/18 vaccine efficacy against cervical, anal and oral HPV infection. J Natl Cancer Inst 108(1)

    Google Scholar 

  • Brotherton M, Jit M, Gravitt PE, Brisson M, Kreimer AR, Pai SI, Fakhry C, Monsonego J, Franceschi S. (2016) Eurogin roadmap 2015: how has HPV knowledge changed our practice: vaccines. Int J Cancer (Epub ahead of print)

    Google Scholar 

  • Cameron JE, Snowhite IV, Chaturvedi AK, Hagensee ME (2003) Human papillomavirus-specific antibody status in oral fluids modestly reflects serum status in human immunodeficiency virus-positive individuals. Clin Diagn Lab Immunol 10(3):431–438

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, Jiang B, Goodman MT, Sibug-Saber M, Cozen W, Liu L, Lynch CF, Wentzensen N, Jordan RC, Alterkruse S, Anderson WF, Rosenberg PS, Gillison ML (2011) Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 29:4294–4301

    Article  PubMed  PubMed Central  Google Scholar 

  • Chisanga C, Eggert D, Mitchell CD, Wood C, Angeletti PC (2015) Evidence for placental HPV infection in both HIV positive and negative women. J Cancer Ther 6(15):1276–1289

    Article  PubMed  PubMed Central  Google Scholar 

  • Chung CH, Bagheri A, D’Souza G (2013) Epidemiology of oral human papillomavirus infection. Oral Oncol S1368-8375(13):00685-4

    Google Scholar 

  • Edelstein ZR, Schwartz SM, Hawes S, Hughes JP, Feng Q, Stern ME et al (2012) Rates and determinants of oral human papillomavirus infection in young men. Sex Trans Dis 39:860–867

    Article  Google Scholar 

  • Einstein MH, Takacs P, Chatterjee A, Sperling RS, Chakhtoura N, Blatter MM, Lalezari J, David MP, Lin L, Struyf F, Dubin G; HPV-101 Study Group (2014) Comparison of long-term immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18–45 years: end-of-study analysis of a phase III randomized trial. Human Vaccin Immunother 10(12):3435–3445

    Google Scholar 

  • Fruscalzo A, Londero AP, Bertozzi S, Lelle RJ (2016) Second-generation prophylactic HPV vaccines: current options and future strategies for vaccines development. Minerva Med 107:26–38

    PubMed  Google Scholar 

  • Gama RR, Carvalho AL, Filho AL, Scorsato AP, Lopez RV, Rautava J, Syrjänen S, Syrjänen K (2016) Detection of human papillomavirus in laryngeal squamous cell carcinoma: systematic review and meta-analysis. Laryngoscope 126(4):885–893

    Google Scholar 

  • Garland SM, Smith JS (2010) Human papillomavirus vaccines: current status and future prospects. Drugs 70:1079–1098

    Article  PubMed  Google Scholar 

  • Gillison ML, Broutian T, Pickard RK, Tong ZY, Xiao W, Kahle L, Graubard BI, Chaturvedi AK (2012) Prevalence of oral HPV infection in the United States, 2009–2010. JAMA 307:693–703

    Article  CAS  PubMed  Google Scholar 

  • Giuliano AR, Palefsky JM, Goldstone S, Moreira ED Jr, Penny ME, Aranda C, Vardas E, Moi H, Jessen H, Hillman R, Chang YH, Ferris D, Rouleau D, Bryan J, Marshall JB, Vuocolo S, Barr E, Radley D, Haupt RM, Guris D (2011) Efficacy of quadrivalent HPV vaccine against HPV infection and disease in males. N Engl J Med 364(5):401–411

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Goldstone SE, Jessen H, Palefsky JM, Giuliano AR, Moreira ED Jr, Vardas E, Aranda C, Hillman RJ, Ferris DG, Coutlee F, Marshall JB, Vuocolo S, Haupt RM, Guris D, Garner E (2013) Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males. Vaccine 31:3849–3855

    Article  CAS  PubMed  Google Scholar 

  • Gonçalves AK1, Giraldo P, Barros-Mazon S, Gondo ML, Amaral RL, Jacyntho C (2006) Secretory immunoglobulin A in saliva of women with oral and genital HPV infection. Eur J Obstet Gynecol Reprod Biol 124(2):227–231

    Google Scholar 

  • Gooi Z, Chan JY, Fakhry C (2016) The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer. Laryngoscope 126(4):894–900

    Article  PubMed  Google Scholar 

  • Graham DM, Isaranuwatchai W, Habbous S, de Oliveira C, Liu G, Siu LL, Hoch JS (2015) A cost-effectiveness analysis of human papillomavirus vaccination of boys for the prevention of oropharyngeal cancer. Cancer 121:1785–1792

    Article  PubMed  Google Scholar 

  • Grun N, Åhrlund-Richter A, Franzen J, Mirzaie L, Marions L, Ramqvist T, Dalianis T (2015) Oral human papillomavirus (HPV) prevalence in youth and cervical HPV prevalence in women attending a youth clinic in Sweden, a follow up-study 2013-2014 after gradual introduction of public HPV vaccination. Infect Dis 47(1):57–61

    Article  Google Scholar 

  • Handisurya A, Schellenbacher C, Haitel A, Senger T, Kirnbauer R (2016) Human papillomavirus vaccination induces neutralizing antibodies in oral mucosal fluids. Br J Cancer 114:409–416

    Article  CAS  PubMed  Google Scholar 

  • Hardefeldt HA, Cox MR, Eslick GD (2014) Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis. Epidemiol Infect 124(6):1119–1137

    Google Scholar 

  • Haukioja A, Asunta M, Söderling E, Syrjänen S (2014) Persistent oral human papillomavirus infection is associated with smoking and elevated salivary immunoglobulin G concentration. J Clin Virol 61(1):101–106

    Article  CAS  PubMed  Google Scholar 

  • Hermann JS, Weckx LY, Monteiro NJ, Santor GF Jr, Campos PAC, Nagata PSS (2016) Effectiveness of the human papillomavirus (types 6, 11, 16 and 18) vaccine in the treatment of children with recurrent respiratory papillomatosis. Int J Pediatr Otorhinolaryngol 83:94–98

    Google Scholar 

  • Herrero R, Quint W, HIldesheim A, Gonzalez P, Struijk L, Katki HA, Porras C, Schiffman M, Rodriguez AC, Solomon D, Jimenez S, Schiller JT, Lowy DR, van Doorn LJ, Wacholder S, Kreimer AR, CVT Vaccine Group (2013) Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica. PLoS ONE 8(7):e68329

    Google Scholar 

  • Hocevar-Boltezar I, Maticic M, Sereq-Bahar M, Gale N, Poljak M, Kocjan B, Zargi M (2014) Human papilloma virus vaccination in patients with an aggressive course of recurrent respiratory papillomatosis. Eur Arch Otorhinolaryngol 271:3255–3262

    Article  PubMed  Google Scholar 

  • Kemp TJ, Safaeian M, Miner S, Williams MC, Rodrigues AC, Herrero R, Hildesheim A, Pinto AL (2012) Oral immunoglobulin levels are not a good surrogate for cervical immunoglobulin levels. Front Oncol 2:61

    Article  PubMed  PubMed Central  Google Scholar 

  • Kero K, Rautava J, Syrjänen K, Grenman S, Syrjänen S (2012) Oral mucosa as a reservoir of human papillomavirus: point prevalence, genotype distribution, and incident infections among males in a 7-year prospective study. Eur Urol 62(6):1063–1070

    Article  PubMed  Google Scholar 

  • Kero K, Rautava J, Syrjänen K, Willberg J, Grenman S, Syrjänen S (2014) Smoking increases oral HPV persistence among men: 7-year follow-up study. Eur J Clin Microbiol Infect Dis 33(1):123–133

    Article  CAS  PubMed  Google Scholar 

  • Kichaev G, Mendoza JM, Amante D, Smith TR, McCoy JR, Sardesai NY, Broderick KE (2013) Electroporation mediated DNA vaccination directly to a mucosal surface results in improved immune responses. Hum Vaccin Immunother 9(10):2014–2018

    Article  Google Scholar 

  • Kirnbauer R, Booy F, Cheng N, Lowy DR, Schiller JT (1992) Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc Natl Acad Sci USA 89(24):12180–12184

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Koskimaa HM, Waterboer T, Pawlita M, Grenman S, Syrjänen K, Syrjänen S (2012) Human papillomavirus genotypes present in the oral mucosa of newborns and their concordance with maternal cervical human papillomavirus genotypes. J Pediatr 160(5):837–843

    Google Scholar 

  • Koskimaa HM, Paaso AE, Welters MJ, Grenman SE, Syrjänen KJ, van der Burg SH, Syrjänen SM (2014) J Transl Med 12:44

    Article  PubMed  PubMed Central  Google Scholar 

  • Koskimaa HM, Paaso A, Welters MJ, Grenman S, Syrjänen K, van der Burg SH, Syrjänen S (2015) Human papillomavirus 16-specific cell-mediated immunity in children born to mothers with incident cervical intraepithelial neoplasia (CIN) and to those constantly HPV negative. J Transl Med 13:370

    Article  PubMed  PubMed Central  Google Scholar 

  • Kreimer AR, Johansson M, Waterboer T, Kaaks R, Chang-Claude J, Drogen D, Tjonneland A, Overvad K, Quiros JR, Gonzalez CA, Sanchez MJ, Larranaga N, Navarro C, Barricarte A, Travis RC, Khaw KT, Wareham N, Trichopoulos A, Lagiou P, Trichopoulos D, Peeters PH, Panico S, Masala G, Grioni S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Laurell G, Hallmans G, Manjer J, Ekström J, Skele G, Lund E, Weiderpass E, Ferrari P, Byrnes G, Romineu I, Riboli E, Hildesheim A, Boeing H, Pawlita M, Brennan P (2013) Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer. J Clin Oncol 31(21):2708–2715

    Article  PubMed  PubMed Central  Google Scholar 

  • Lang Kuhs KA, Pawlita M, Gibson SP, Schmitt NC, Trivedi S, Argiris A, Kreimer AR, Ferris RL, Waterboer T (2016) Characterization of human papillomavirus antibodies in individuals with head and neck cancer. Cancer Epidemiol 42:46–52

    Google Scholar 

  • Laprise C, Trottier H, Monnier P, Coutlee F, Mayrand MH (2014) Prevalence of human papillomavirus in semen: a systematic review and meta-analysis. Hum Reprod 29(4):640–651

    Article  PubMed  Google Scholar 

  • Lescaille G, Pitoiset F, Macedo R, Baillou C, Huret C, Klatzmann D et al (2013) Efficacy of DNA vaccines forming E7 recombinant retroviral virus-like particles for the treatment of human papillomavirus-induced cancers. Hum Gen Ther 24:533–544

    Article  CAS  Google Scholar 

  • Lu B, Viscidi RP, Lee JH, Wu Y, Villa LL, Lazcano-Ponce E, da Silva RJ, Baggio ML, Quiterio M, Salmeron J, Smith DC, Abrahamsen M, Papenfuss M, Stockwell HG, Giuliano AR (2011) Human papillomavirus (HPV) 6, 11, 16 and 18 seroprevalence is associated with sexual practice and age: results from the multinational HPV infection in men study (HIM study). Cancer Epidemiol Biomark Prev 20:990–1002

    Article  Google Scholar 

  • Lyford-Pike S, Peng S, Young GD, Taube JM, Westra WH, Akpeng B, Bruno TC, Richmon JD, Wang H, Bishop JA, Chen L, Drake CG, Topallan SL, Pardoll DM, Pai SI (2013) Evidence for a role of the PD-1: PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Res 73(6):1733–1741

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Malagon T, Drolet M, Bolly MC, Franco EL, Jit M, Brisson J, Brisson M (2012) Cross-protective efficacy of two human papillomavirus vaccines: a systematic review and meta-analysis. Lancer Infect Dis 12(10):781–789

    Article  CAS  Google Scholar 

  • Marais DJ, Sampson C, Jeftha A, Dhaya D, Passmore JA, Denny L, Rybicki EP, Van Der Walt E, Stephen LX, Williamson AL (2006) More men than women make mucosal IgA antibodies to Human papillomavirus type 16 (HPV-16) and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy population. BMC Infect Dis 6:95

    Article  PubMed  PubMed Central  Google Scholar 

  • Marur S, Forastiere AA (2016) Head and neck squamous cell carcinoma: update on epidemiology, diagnosis, and treatment. Mayo Clin Proc 91(3):386–396

    Article  PubMed  Google Scholar 

  • Mehanna H, Beech T, Nicholson T, El-Hariry I, McConkey C, Paleri V, Roberts S (2013) Head Neck 35(5):747–755

    Google Scholar 

  • Mondini M, Nizard M, Tran T, Mauge L, Loi M, Clemenson C, Dugue D, Maroun P, Louvet E, Adam J, Badoual C, Helley D, Dransart E, Johannes L, Vozenin MC, Perfettini JL, Tartour E, Deutsch E (2015) Synergy of radiotherapy and a cancer vaccine for the treatment of HPV-associated head and neck cancer. Mol Cancer Ther 14:1336–1345

    Article  CAS  PubMed  Google Scholar 

  • Olsson SE, Villa LL, Costa RL, Petta CA, Andrade RP, Malm C, Iversen OE, Hoye J, Steinwall M, Riis-Johannssen G, Andersson-Ellstrom A, Elfgren K, von Krogh G, Lehtinen M, Paavonen J, Tamms GM, Giacoletti K, Lupinacci L, Esser MT, Vuocolo SC, Saah AJ, Barr E (2007) Induction of immune memory following administration of a prophylactic quadrivalent human papillomavirus (HPV) types 6/11/16/18 virus-like particle (VLP) vaccine. Vaccine 21(25):4931–4939

    Article  Google Scholar 

  • Palefsky JM, Giuliano AR, Goldstone S, Moreira ED Jr, Aranda C, Jessen H, Hillman R, Ferris D, Coutlee F, Stoler MH, Marshall JB, Radley D, Vuocolo S, Haupt RM, Guris D, Garner EI (2011) HPV vaccine against anal HPV infection and anal intraepithelial neoplasia. N Engl J Med 365(17):1576–1585

    Article  CAS  PubMed  Google Scholar 

  • Passmore JA, Marais DJ, Sampson C, Allan B, Parker N, Milner M, Denny L, Williamson AL (2007) Cervicovaginal, oral, and serum IgG and IgA responses to human papillomavirus type 16 in women with cervical intraepithelial neoplasia. J Med Virol 79:1375–1380

    Article  PubMed  Google Scholar 

  • Pickard RK, Xiao W, Broutian TR, He X, Gillison ML (2012) The prevalence and incidence of oral human papillomavirus infection among young men and women, aged 18-30 years. Sex Transm Dis 39:559–566

    Article  PubMed  Google Scholar 

  • Rautava J, Willberg J, Louvanto K, Wideman L, Syrjänen K, Grenman S, Syrjänen S (2012a) Prevalence, genotype distribution and persistence of human papillomavirus in oral mucosa of women: a six-year follow-up study. PLoS ONE 7(8):e42171

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rautava J, Kuuskoski J, Syrjänen K, Grenman R, Syrjänen S (2012b) HPV genotypes and their prognostic significance in head and neck squamous cell carcinomas. J Clin Virol 53:116–120

    Article  PubMed  Google Scholar 

  • Reuschenbach M, Pauligk C, Karbach J, Rafiyan MR, Kloor M, Prigge ES, Sauer M, Al-Batran SE, Kaufmann AM, Schneider A, Jäger E, von Knebel Doeberitz M (2016) A phase 1/2a study to test the safety and immunogenicity of a p 16INK4a peptide vaccine in patients with advanced human papillomavirus-associated cancers. Cancer 112(9):1425–1433

    Google Scholar 

  • Rintala MA, Grenman SE, Pöllänen PP, Suominen JJ, Syrjänen SM (2004) Detection of high-risk HPV DNA in semen and its association with the quality of semen. Int J STD AIDS 15(11):740–743

    Article  CAS  PubMed  Google Scholar 

  • Rintala MA, Grenman SE, Järvenkylä ME, Syrjänen KJ, Syrjänen SM (2005) High-risk types of human papillomavirus (HPV) DNA in oral and genital mucosa of infants during their first 3 years of life: experience from the Finnish HPV Family Study. Clin Infect Dis 41(12):1728–1733

    Article  PubMed  Google Scholar 

  • Roteli-Martins C, NAud P, De Borba P, Teixeira J, De Carvalho N, Zahaf T et al (2012) Sustained immunogenicity and efficacy of the HPV-16/18 As04-adjuvant vaccine: up to 8.4 years of follow-up. Hum Vaccin Immunother 8(3):1

    Google Scholar 

  • Sarkola ME, Grenman SE, Rintala MA, Syrjänen KJ, Syrjänen SM (2008) Human papillomavirus in the placenta and umbilical cord blood. Acta Obstet Gynecol Scand 87(11):1181–1188

    Article  PubMed  Google Scholar 

  • Schiller JT, Castellsague X, Garland SM (2012) A review of clinical trials of human papillomavirus prophylactic vaccines. Vaccine 20(30):5

    Google Scholar 

  • Shaikh MH, McMillan NA, Johnson NW (2015) HPV-associated head and neck cancers in the Asia Pacific: a critical literature review and meta-analysis. Cancer Epidemiol 39(6):923–938

    Google Scholar 

  • Skoczynski M, Gozdzicka-Jozefiak A, Kwasniewska A (2015) The prevalence of human papillomavirus between the neonates and their mothers. Biomed Res Int 2015:126417

    Article  PubMed  PubMed Central  Google Scholar 

  • Smith EM, Swarnavel S, Ritchie JM, Wang D, Haugen TH, Turek LR (2007) Prevalence of human papillomavirus in the oral cavity/oropharynx in large population of children and adolescents. Pediatr Infect Dis J 26:836–840

    Article  PubMed  Google Scholar 

  • Summersgill KF, Smith EM, Levy BT, Allen JM, Haugen TH, Turek LP (2001) Human papillomavirus in the oral cavities of children and adolescents. Oral Sug Oral Med Oral Pathol Oral Radiol Endod 91:62–69

    Article  CAS  Google Scholar 

  • Syrjänen K (2013) Geographic origin is a significant determinant of human papillomavirus prevalence in oesophageal squamous cell carcinoma: systematic review and meta-analysis. Scand J Infect Dis 45:1–18

    Google Scholar 

  • Syrjänen K, Syrjänen S (2013) Detection of human papillomavirus (HPV) in sinonasal carcinoma: systematic review and meta-analysis. Hum Pathol 44:983–991

    Google Scholar 

  • Syrjänen S, Rintala M, Willberg J, Rautava J, Koskimaa H, Paaso A, Kero K, Louvanto K, Syrjänen K, Grenman S. Oral HPV infections in nonsexually active children six-year incidence, clearance and persistence. Submitted

    Google Scholar 

  • Takes RP, Wierzbicka M, D’Souza G, Jackowska J, Silver CE, Rodrigo JP, Dikkers FG, Olsen KD, Rinaldo A, Brakenhoff RH, Ferlito A (2015) HPV vaccination to prevent oropharyngeal carcinoma: What can be learned from anogenital vaccination programs? Oral Oncol 51(21):1057–1060

    Google Scholar 

  • Termine N, Panzarella V, Falaschini S, Russo A, Matranga D, Lo Muzio L, Campisi G (2008) HPV in oral squamous cell carcinoma vs head and neck squamous cell carcinoma biopsies: a meta-analysis (1988–2007). Ann Oncol 19(10):1681–1690

    Google Scholar 

  • Zandberg DP, Rollins S, Goloubeva O, Morales RE, Tan M, Taylor R, Wolf JS, Schumaker LM, Cullen KJ, Zimrin A, Ord R, Lubek JE, Suntharalingam M (2015) A phase I dose escalation trial of MAGE-A3- and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN). Cancer Immunol Immunother 64:367–379

    Article  CAS  PubMed  Google Scholar 

  • Zhang SK, Guo LW, Chen Q, Zhang M, Liu SZ, Quan PL, Lu JB, Sun XB (2014) Prevalence of human papillomavirus 16 in esophageal cancer among the Chinese population: a systematic review and meta-analysis. Asian Pac J Cancer Prev 15(23):10143–10149

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oral Pathology, Faculty of Medicine, Turku University Hospital, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520, Turku, Finland

    Stina Syrjänen & Jaana Rautava

Authors
  1. Stina Syrjänen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jaana Rautava
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stina Syrjänen .

Editor information

Editors and Affiliations

  1. Department of Head and Neck Surgery, Poznan University of Medical Sciences, The Greater Poland Cancer Centre, Poznań, Poland

    Wojciech Golusiński

  2. Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center/Cancer Center Amsterdam, Amsterdam, The Netherlands

    C. René Leemans

  3. Dept. of Head Medicine and Oral Health, University of Leipzig Clinic of Otolaryngology, Leipzig, Germany

    Andreas Dietz

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Syrjänen, S., Rautava, J. (2017). Vaccination Expectations in HNSCC. In: Golusiński, W., Leemans, C., Dietz, A. (eds) HPV Infection in Head and Neck Cancer. Recent Results in Cancer Research, vol 206. Springer, Cham. https://doi.org/10.1007/978-3-319-43580-0_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-43580-0_21

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-43578-7

  • Online ISBN: 978-3-319-43580-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation