Skip to main content

Risk Groups for Survival in HPV-Positive and HPV-Negative OPSCC

  • Chapter
  • First Online:
HPV Infection in Head and Neck Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 206))

  • 1727 Accesses

Abstract

Over the last three decades, it has become clear that infection with high-risk human papillomavirus (HPV) is etiologically linked to the development of head and neck squamous cell carcinomas, particularly those carcinomas that arise in the oropharyngeal region.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ang KK, Harris J, Wheeler R et al (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363:24–35

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bao S, Wu Q, McLendon RE et al (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756–760

    Article  CAS  PubMed  Google Scholar 

  • Begum S, Westra WH (2008) Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. Am J Surg Pathol 32:1044–1050

    Article  PubMed  Google Scholar 

  • Butz K, Geisen C, Ullmann A et al (1996) Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: repression of E6/E7-oncogene expression and induction of apoptosis. Int J Cancer 68:506–513

    Article  CAS  PubMed  Google Scholar 

  • Chang AR, Wu HG, Park CI et al (2008) Expression of epidermal growth factor receptor and cyclin D1 in pretreatment biopsies as a predictive factor of radiotherapy efficacy in early glottic cancer. Head Neck 30:852–857

    Article  PubMed  Google Scholar 

  • Chaturvedi AK, Engels EA, Pfeiffer RM et al (2011) Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 29:4294–4301

    Article  PubMed  PubMed Central  Google Scholar 

  • Dahlstrom KR, Calzada G, Hanby JD, et al (2012) An evolution in demographics, treatment, and outcomes of oropharyngeal cancer at a major cancer center: a staging system in need of repair. Cancer

    Google Scholar 

  • de Jong MC, Pramana J, Van Der Wal JE et al (2010) CD44 expression predicts local recurrence after radiotherapy in larynx cancer. Clin Cancer Res 16:5329–5338

    Article  PubMed  Google Scholar 

  • Fakhry C, Westra WH, Li S et al (2008) Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 100:261–269

    Article  CAS  PubMed  Google Scholar 

  • Fischer C, Zlobec I, Stockli E et al (2008) Is immunohistochemical epidermal growth factor receptor expression overestimated as a prognostic factor in head-neck squamous cell carcinoma? A retrospective analysis based on a tissue microarray of 365 carcinomas. Hum Pathol 39:1527–1534

    Article  CAS  PubMed  Google Scholar 

  • Gillison ML, Koch WM, Capone RB et al (2000) Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92:709–720

    Article  CAS  PubMed  Google Scholar 

  • Gillison ML, D’Souza G, Westra W et al (2008) Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 100:407–420

    Article  PubMed  Google Scholar 

  • Granata R, Miceli R, Orlandi E et al (2012) Tumor stage, human papillomavirus and smoking status affect the survival of patients with oropharyngeal cancer: an Italian validation study. Ann Oncol 23:1832–1837

    Article  CAS  PubMed  Google Scholar 

  • Hafkamp HC, Manni JJ, Haesevoets A et al (2008) Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas. Int J Cancer 122:2656–2664

    Article  CAS  PubMed  Google Scholar 

  • Hong A, Dobbins T, Lee CS et al (2010) Relationships between epidermal growth factor receptor expression and human papillomavirus status as markers of prognosis in oropharyngeal cancer. Eur J Cancer 46:2088–2096

    Article  CAS  PubMed  Google Scholar 

  • Huang SH, Perez-Ordonez B, Liu FF et al (2012) Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy. Int J Radiat Oncol Biol Phys 82:276–283

    Article  PubMed  Google Scholar 

  • Kallogjeri D, Piccirillo JF, Spitznagel EL Jr et al (2012) Comparison of scoring methods for ACE-27: simpler is better. J Geriatr Oncol 3:238–245

    Article  PubMed  PubMed Central  Google Scholar 

  • Kaplan MH, Feinstein AR (1974) The importance of classifying initial co-morbidity in evaluating the outcome of diabetes mellitus. J Chronic Dis 27:387–404

    Article  CAS  PubMed  Google Scholar 

  • Kong CS, Narasimhan B, Cao H et al (2009) The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys 74:553–561

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lindel K, Beer KT, Laissue J et al (2001) Human papillomavirus positive squamous cell carcinoma of the oropharynx: a radiosensitive subgroup of head and neck carcinoma. Cancer 92:805–813

    Article  CAS  PubMed  Google Scholar 

  • Lindquist D, Romanitan M, Hammarstedt L et al (2007) Human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of E6 and E7. Mol Oncol 1:350–355

    Article  PubMed  Google Scholar 

  • Martens-de Kemp SR, Brink A, Stigter-van WM et al (2013) CD98 marks a subpopulation of head and neck squamous cell carcinoma cells with stem cell properties. Stem Cell Res 10:477–488

    Google Scholar 

  • Murphy CT, Devarajan K, Wang LS et al (2015) Pre-treatment tumor-specific growth rate as a temporal biomarker that predicts treatment failure and improves risk stratification for oropharyngeal cancer. Oral Oncol 51:1034–1040

    Article  PubMed  Google Scholar 

  • Nasman A, Attner P, Hammarstedt L et al (2009) Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma? Int J Cancer 125:362–366

    Article  PubMed  Google Scholar 

  • O’Sullivan B, Huang SH, Perez-Ordonez B et al (2012) Outcomes of HPV-related oropharyngeal cancer patients treated by radiotherapy alone using altered fractionation. Radiother Oncol 103:49–56

    Article  PubMed  Google Scholar 

  • O’Sullivan B, Huang SH, Siu LL et al (2013) Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol 31:543–550

    Article  PubMed  Google Scholar 

  • Perrone F, Gloghini A, Cortelazzi B et al (2011) Isolating p16-positive/HPV-negative oropharyngeal cancer: an effort worth making. Am J Surg Pathol 35:774–777

    Article  PubMed  Google Scholar 

  • Posner MR, Lorch JH, Goloubeva O et al (2011) Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial. Ann Oncol 22:1071–1077

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Putti TC, To KF, Hsu HC et al (2002) Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: a multicentre immunohistochemical study in the Asia-Pacific region. Histopathology 41:144–151

    Article  CAS  PubMed  Google Scholar 

  • Rietbergen MM, Leemans CR, Bloemena E et al (2013a) Increasing prevalence rates of HPV attributable oropharyngeal squamous cell carcinomas in the Netherlands as assessed by a validated test algorithm. Int J Cancer 132:1565–1571

    Article  CAS  PubMed  Google Scholar 

  • Rietbergen MM, Brakenhoff RH, Bloemena E et al (2013b) Human papillomavirus detection and comorbidity: critical issues in selection of patients with oropharyngeal cancer for treatment De-escalation trials. Ann Oncol 24:2740–2745

    Article  CAS  PubMed  Google Scholar 

  • Rietbergen MM, Martens-de Kemp SR, Bloemena E et al (2014) Cancer stem cell enrichment marker CD98: a prognostic factor for survival in patients with human papillomavirus-positive oropharyngeal cancer. Eur J Cancer 50:765–773

    Google Scholar 

  • Rietbergen MM, Witte BI, Velazquez ER et al (2015) Different prognostic models for different patient populations: validation of a new prognostic model for patients with oropharyngeal cancer in Western Europe. Br J Cancer 112:1733–1736

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rios VE, Hoebers F, Aerts HJ et al (2014) Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging. Radiother Oncol 113:324–330

    Article  Google Scholar 

  • Rischin D, Young RJ, Fisher R et al (2010) Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial. J Clin Oncol 28:4142–4148

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shaw R, Robinson M (2011) The increasing clinical relevance of human papillomavirus type 16 (HPV-16) infection in oropharyngeal cancer. Br J Oral Maxillofac Surg 49:423–429

    Article  PubMed  Google Scholar 

  • Thomas GR, Nadiminti H, Regalado J (2005) Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma. Int J Exp Pathol 86:347–363

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vainshtein JM, Spector ME, McHugh JB et al (2014) Refining risk stratification for locoregional failure after chemoradiotherapy in human papillomavirus-associated oropharyngeal cancer. Oral Oncol 50:513–519

    Article  PubMed  PubMed Central  Google Scholar 

  • Ward MJ, Thirdborough SM, Mellows T et al (2014) Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer. Br J Cancer 110:489–500

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to C. René Leemans .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Rietbergen, M.M., Brakenhoff, R.H., RenĂ© Leemans, C. (2017). Risk Groups for Survival in HPV-Positive and HPV-Negative OPSCC. In: GolusiÅ„ski, W., Leemans, C., Dietz, A. (eds) HPV Infection in Head and Neck Cancer. Recent Results in Cancer Research, vol 206. Springer, Cham. https://doi.org/10.1007/978-3-319-43580-0_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-43580-0_17

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-43578-7

  • Online ISBN: 978-3-319-43580-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics