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Nano-emulsions for Drug Delivery and Biomedical Imaging

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Intracellular Delivery III

Part of the book series: Fundamental Biomedical Technologies ((FBMT))

Abstract

Over the last decade, nano-emulsion has gained a considerable interest in biomedical applications. The reason is simple, and lies in the combination of several advantages of this nano-carrier. Nano-emulsion consists of a dispersion of oil nano-droplets in a water phase, sizing from 20 to 200 nm. First advantage of nano-emulsions is their huge stability; Second is their very simple formulation; Third is their non-toxicity; And fourth is their very important loading capability of lipophilic or oil-soluble molecules in the oily core of the nano-droplets. On the other hand, if the formulation is easy, tailoring the nano-emulsions for a given application, optimizing the processes, functionalizing the droplets surface, and targeting organs or cancerous tumors remains a challenge. This chapter aims to draw an overview of the different aspects of nano-emulsions formulations and applications. A first part regards the different fabrication processes, followed by biomedical applications of nano-emulsions, in vivo fate, biodistribution, pharmacokinetics, targeting, applications as nanomedicines and drug delivery systems. Clinical applications of nano-emulsions are also discussed, as well as their applications as contrast agent for the main different imaging modalities, X-ray imaging, fluorescence imaging and magnetic resonance imaging.

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Abbreviations

ALA:

Aminolaevulinic acid

AK:

Actinic keratosis

BF200 ALA:

BF200 aminolaevulinic acid

CMC:

Critical micelle concentration

CT:

Computed tomography

DLS:

Dynamic light scattering

DTPA- PE:

Diethylenetriaminepentaacetic acid phosphoethanolamine

DTX:

Docetaxel

EPR:

Enhanced permeation and retention

HLB:

Hydrophilic-lipophilic balance

IONPs:

Iron oxide nanoparticles

LNP:

Lipid nanoparticle

MAL:

5-aminolaevulinic acid

MRI:

Magnetic resonance imaging

NIR:

Near infrared

NIRF:

Near infrared fluorescence

NMR:

Nuclear magnetic resonance

NPs:

Nanoparticle

PAV:

Prednisolone acetate valerate

PBS:

Phosphate buffer saline

PET:

Positron emission tomography

PDI:

Polydispersity index

PEG:

Polyethylene glycol

PFCs:

Perfluorocarbons

PFPE:

Perfluoropolyether

QDs:

Quantum-dots

RES:

Rethiculoendothelial system

SPECT:

Single photon emission computed tomography

SPIO:

Superparamagnetic iron oxide

TEM:

Transmission electron microscopy

TXT:

Taxotere®

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Authors and Affiliations

  1. CNRS UMR 7199, Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, University of Strasbourg, 74 route du Rhin, 67401, Illkirch Cedex, France

    Nicolas Anton, Mohamed F. Attia & Thierry F. Vandamme

  2. DC2N Inserm U982, Laboratoire de Pharmacie Galénique Biopharmacie, Faculté de Médicine & Pharmacie, Université de Rouen, Rouen, France

    François Hallouard

  3. Service de Pharmacie, Centre Hospitalier Asselin Hédelin, Yvetot, France

    François Hallouard

  4. National Research Center, 12622, Cairo, Egypt

    Mohamed F. Attia

Authors
  1. Nicolas Anton
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  2. François Hallouard
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  3. Mohamed F. Attia
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  4. Thierry F. Vandamme
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Corresponding author

Correspondence to Nicolas Anton .

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Editors and Affiliations

  1. Biomolecular and Chemical Engineering, Vanderbilt University Biomolecular and Chemical Engineering, Nashville, Tennessee, USA

    Aleš Prokop

  2. Pharmaceutical Sciences, Midwestern University Pharmaceutical Sciences, GLENDALE, Arizona, USA

    Volkmar Weissig

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Anton, N., Hallouard, F., Attia, M.F., Vandamme, T.F. (2016). Nano-emulsions for Drug Delivery and Biomedical Imaging. In: Prokop, A., Weissig, V. (eds) Intracellular Delivery III. Fundamental Biomedical Technologies. Springer, Cham. https://doi.org/10.1007/978-3-319-43525-1_11

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