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Salivary Gland Development and Regeneration pp 23–44Cite as

Systems Biology: Salivary Gland Development, Disease, and Regenerative Medicine

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Abstract

There are multiple challenges currently facing clinical salivary gland research, encompassing a wide range of topics from understanding development to understanding disease etiology and from diagnosing disease to designing more effective, personalized therapies. Systems analysis complements traditional reductionist approaches, and the integration of these two approaches is starting to provide a more comprehensive understanding of the causal relationships leading to normal and abnormal biology. Understanding normal developmental processes is critical for understanding development of disease. Morphogenesis and differentiation are complex developmental processes involving orchestrated interactions between heterotypic cell types that have proven difficult to understand through reductionist approaches alone. It has become clear that it is not possible to understand the complex molecular, cellular, and physical process integration that is required for any developmental or disease process without the use of systems biology approaches. In this chapter, we demonstrate examples in the use of systems approaches to better characterize the difference between embryonic submandibular salivary glands grown in vivo and ex vivo as 3D organ explants and to identify potential signaling networks in heterotypic subpopulations of cells that lead to the prediction of a function for endothelial cells in salivary gland development. We conclude with examples of how systems biology-based approaches using both tissue samples and saliva from patients are currently being used in many laboratories to make progress in salivary gland disease diagnosis, understanding disease etiology, and informing therapeutic development for cancer and regenerative medicine strategies.

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Notes

  1. 1.

    http://sgmap.nidcr.nih.gov/sgmap/sgexp.html

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Acknowledgments

The authors thank Kenneth Yamada and Matthew Hoffman for reviewing the manuscript. This work was sponsored in part by the University at Albany, SUNY, and by NIH grants R01DE022467 and C06 RR015464.

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Authors and Affiliations

  1. Department of Biological Sciences, University at Albany, SUNY, State University of New York, 1400 Washington Ave LSRB 1086, Albany, NY, 12222, USA

    Melinda Larsen PhD, Hae Ryong Kwon PhD, Deirdre A. Nelson, Connor Duffy & Sarah B. Peters PhD

  2. Oklahoma Medical Research Foundation, Oklahoma, OK, USA

    Melinda Larsen PhD, Hae Ryong Kwon PhD, Deirdre A. Nelson & Connor Duffy

  3. Department of Computer Science, University at Albany, SUNY, State University of New York, 1400 Washington Ave, Albany, NY, 12222, USA

    Petko Bogdanov PhD & Ravi Sood

  4. Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, 1918 University Blvd., MCML 643, Birmingham, AL, 35294, USA

    Sarah B. Peters PhD

  5. Center for Functional Genomics, University at Albany, SUNY, State University of New York, Health Sciences Campus, One Discovery Drive, Albany, NY, 12144, USA

    Sridar V. Chittur PhD

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  1. Melinda Larsen PhD
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Correspondence to Melinda Larsen PhD .

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Editors and Affiliations

  1. Oral and Maxillofacial Diagnostic Sciences, University of Florida, Gainesville, Florida, USA

    Seunghee Cha

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Larsen, M. et al. (2017). Systems Biology: Salivary Gland Development, Disease, and Regenerative Medicine. In: Cha, S. (eds) Salivary Gland Development and Regeneration. Springer, Cham. https://doi.org/10.1007/978-3-319-43513-8_2

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  • DOI: https://doi.org/10.1007/978-3-319-43513-8_2

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