Skip to main content

Imaging Biomarker Structural Analysis

  • Chapter
  • First Online:
Imaging Biomarkers
  • 1128 Accesses

Abstract

Medical imaging has a key role in current workflows for the assessment of clinical decisions in many disease scenarios. Concretely, imaging biomarkers are transforming the way radiology has taken part in the healthcare cycle, from conventional workflows based on qualitative criteria and the experience of the radiologist toward having a powerful measurement tool in each hospital, allowing for the extraction of quantitative indicators of tissue and organ characteristics by the application of image processing methods and algorithms to medical images from modalities like X-ray (XR), magnetic resonance (MR) imaging, computed tomography (CT), ultrasound (US), positron emission tomography (PET), single-photon emission computed tomography (SPECT), among others.

Imaging biomarkers analysis methods can be structured both in those related to structural properties and those focused on analyzing dynamic features. In the present chapter, we will focus on the explanation and description of structural imaging biomarkers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D, Verweij J. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45(2):228–47.

    Article  CAS  PubMed  Google Scholar 

  2. Lin M, Pellerin O, Bhagat N, Rao PP, Loffroy R, Ardon R, Mory B, Reyes DK, Geschwind JF. Quantitative and volumetric European Association for the Study of the Liver and Response Evaluation Criteria in Solid Tumors measurements: feasibility of a semiautomated software method to assess tumor response after transcatheter arterial chemoembolization. J Vasc Interv Radiol. 2012;23(12):1629–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Roque WL, Arcaro K, Alberich-Bayarri A. Mechanical competence of bone: a new parameter to grade trabecular bone fragility from tortuosity and elasticity. IEEE Trans Biomed Eng. 2013;60(5):1363–70.

    Article  PubMed  Google Scholar 

  4. Nougaret S, et al. MR Volumetric Measurement of Low Rectal Cancer Helps Predict Tumor Response and Outcome after Combined Chemotherapy and Radiation Therapy. Radiology. 2012;263(2):409–18.

    Article  PubMed  Google Scholar 

  5. Mayr NA, Magnotta VA, Ehrhardt JC, Wheeler JA, Sorosky JI, Wen BC, Davis CS, Pelsang RE, Anderson B, Doornbos JF, Hussey DH, Yuh WT. Usefulness of tumor volumetry by magnetic resonance imaging in assessing response to radiation therapy in carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys. 1996;35:915–24.

    Article  CAS  PubMed  Google Scholar 

  6. Andreopoulou E, Andreopoulos D, Adamidis K, Fountzila-Kalogera A, Fountzilas G, Dimopoulos MA, Aravantinos G, Zamboglou N, Baltas D, Pavlidis N. Tumor volumetry as predictive and prognostic factor in the management of ovarian cancer. Anticancer Res. 2002;22:1903–8.

    CAS  PubMed  Google Scholar 

  7. Mandelbrot BB. The Fractal Geometry of Nature. New York: W.H. Freeman and Company; 1982.

    Google Scholar 

  8. Sanghera B, Banerjee D, Khan A, Simcock I, Stirling JJ, Glynne-Jones R, Goh V. Reproducibility of 2D and 3D fractal analysis techniques for the assessment of spatial heterogeneity of regional blood flow in rectal cancer. Radiology. 2012;263(3):865–73.

    Article  PubMed  Google Scholar 

  9. Lee J, Narang S, Martinez JJ, Rao G, Rao A. Associating spatial diversity features of radiologically defined tumor habitats with epidermal growth factor receptor driver status and 12-month survival in glioblastoma: methods and preliminary investigation. J Med Imaging (Bellingham). 2015;2(4):041006.

    Article  Google Scholar 

  10. Mahmoud-Ghoneim D, Toussaint G, Constans JM, de Certaines JD. Three dimensional texture analysis in MRI: a preliminary evaluation in gliomas. Magn Reson Imaging. 2003 Nov;21(9):983–7. PubMed PMID: 14684200.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Angel Alberich-Bayarri .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Alberich-Bayarri, A. (2017). Imaging Biomarker Structural Analysis. In: Martí-Bonmatí, L., Alberich-Bayarri, A. (eds) Imaging Biomarkers. Springer, Cham. https://doi.org/10.1007/978-3-319-43504-6_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-43504-6_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-43502-2

  • Online ISBN: 978-3-319-43504-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics