Abstract
The need for long-term mechanical support in the pediatric population has been recognized for many years. Annually, about 300–500 pediatric heart transplants are performed worldwide, but many more could be done if donors were available. The US National Institutes of Health (NIH) estimates that in the USA there are ~1800 infant deaths from congenital heart defects annually and several hundred additional pediatric patients under 5 years old who develop heart failure. Left ventricular assist devices (LVADs) in pediatrics are frequently implanted as a bridge to transplantation (BTT) and rarely for recovery or as destination therapy (DT). The number of pediatric patients suffering from end-stage heart failure is continuously increasing, and assisting smallest ones in a long-term strategy remains an unsolved problem. This is mainly because today only one-labeled VAD is available for neonates and infants, namely, the Berlin Heart EXCOR (BHE) that is a paracorporeal pulsatile pneumatic-driven system. This has substantially limited the system’s portability which has been a barrier to hospital discharge. BHE is a second-generation device, and neurological complications vary between 25 and 30% with a survival rate approaching 80% [1–4].
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Amodeo, A., Filippelli, S., Di Molfetta, A., Perri, G., Jarvik, R. (2017). Continuous-Flow Pumps in Infants, Jarvik Infant System, and Destination Therapy in Pediatrics. In: Montalto, A., Loforte, A., Musumeci, F., Krabatsch, T., Slaughter, M. (eds) Mechanical Circulatory Support in End-Stage Heart Failure. Springer, Cham. https://doi.org/10.1007/978-3-319-43383-7_39
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DOI: https://doi.org/10.1007/978-3-319-43383-7_39
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