Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder of pathologic immune system activation. Patients with HLH, however, often present critically ill, and HLH should be considered in cases of sepsis-like illness which recur or do not respond to standard treatment. While treatment of HLH with chemotherapy and immunosuppression should be guided by an expert hematologist, the diagnosis is often made by the critical care medicine practitioner. We present a case illustrating the challenges of defining this syndrome in a patient with recurrent critical illness, and review the evidence underlying diagnostic and prognostic criteria for this protean syndrome.
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Singer, B.H., Loomis-King, H.A. (2017). Hemophagocytic Lymphohistiocytosis. In: Hyzy, R. (eds) Evidence-Based Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-319-43341-7_73
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DOI: https://doi.org/10.1007/978-3-319-43341-7_73
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