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Esophageal Manometry

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Abstract

Esophageal manometry has been considered the “gold standard” test for the evaluation of esophageal motor function. At present, abnormal motor activity as measured by “conventional manometry” is defined in terms of a few basic patterns: incomplete sphincter relaxation, esophageal spasm, hypertensive contractions, and loss of tone and motility. Only achalasia and severe diffuse esophageal spasm are specific disorders with manometric abnormalities that are absent in healthy subjects. Other esophageal motility disorders are poorly defined, often include “abnormalities” that can be found in symptom-free individuals as well, and are inconsistent over time. High-resolution manometry (HRM) was developed to increase interpretative consistency and diagnostic accuracy of esophageal manometry. One of the most important advantages of HRM is that it makes diagnostic esophageal manometry easier and quicker to perform. HRM has been shown to increase diagnostic accuracy. Recently, Goldani et al. have illustrated the use of HRM in a pediatric age group while using a standardized protocol and analytical method. Despite the inherent limitations of the pediatric population, the authors introduced a new protocol in un-sedated children in the context of a clinical setting, moving from research into clinical application. The introduction of esophageal pressure topography (EPT) led to new metrics and parameters of HRM and to a modification of the classification scheme, which was originally developed for conventional manometry measurements. In 2008, the first official classification system for EPT was made, the Chicago classification (CC), updated in 2015. However, pediatric normative ranges for EPT metrics and some metrics are lacking.

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References

  1. Savarino E, Tutuian R. Combined multichannel intraluminal impedance and manometry testing. Dig Liver Dis. 2008;40:167–73.

    Article  CAS  PubMed  Google Scholar 

  2. Gilger MA, Boyle JT, Sondheimer JM, Colletti RB. A Medical Position Statement of the North American Society for Pediatric Gastroenterology and Nutrition: indications for pediatric esophageal manometry. J Pediatr Gastroenterol Nutr. 1997;24:616–8.

    Article  CAS  PubMed  Google Scholar 

  3. Clark JH. Anatomy and physiology of the esophagus. In: Wyllie R, Hyams JS, editors. Pediatric gastrointestinal disease, pathophysiology, diagnosis and management. Philadelphia: WB Saunders; 1993. p. 311–7.

    Google Scholar 

  4. Grand RJ, Watkins JB, Torti FM. Development of the human gastrointestinal tract, a review. Gastroenterology. 1976;70:790–810.

    CAS  PubMed  Google Scholar 

  5. Grybowski JD. The swallowing mechanism of the neonate: I. Esophageal and gastric motility. Pediatrics. 1965;35:445–52.

    Google Scholar 

  6. Grybowski JD, Thayer WR, Spiro HM. Esophageal motility in infants and children. Pediatrics. 1963;31:382–95.

    Google Scholar 

  7. Kahrilas PJ, Clouse RE, Hogan WJ. An American Gastroenterological Association Medical Position statement on the clinical use of esophageal manometry. Gastroenterology. 1994;107:1865–84.

    Article  CAS  PubMed  Google Scholar 

  8. Newell SJ, Sarkar PK, Durbin GM, Booth IW, McNeish AS. Maturation of the lower esophageal sphincter in the preterm baby. Gut. 1988;29:167–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Clouse RE, Staiano A, Alrakawi A. Development of a topographic analysis system for manometric studies in the gastrointestinal tract. Gastrointest Endosc. 1998;48:395–401.

    Article  CAS  PubMed  Google Scholar 

  10. Clouse RE, Prakash C. Topographic esophageal manometry: an emerging clinical and investigative approach. Dig Dis Sci. 2000;18:64–74.

    Article  CAS  Google Scholar 

  11. Fox MR, Bredenoord AJ. Esophageal high-resolution manometry: moving from research into clinical practice. Gut. 2008;57:405–23.

    Article  CAS  PubMed  Google Scholar 

  12. Fung KP, Math MV, Ho CO, Yap KM. Midazolam as a sedative in esophageal manometry: a study of the effect on esophageal motility. J Pediatr Gastroenterol Nutr. 1992;15:85–8.

    Article  CAS  PubMed  Google Scholar 

  13. Vanderhoof JA, Rappaport PJ, Paxson CL. Manometric diagnosis of lower esophageal sphincter incompetence in infants: use of a small, single-lumen perfused catheter. Pediatrics. 1978;62:805–8.

    CAS  PubMed  Google Scholar 

  14. Orenstein SR, Giarrusso VS, Proujansky R, Kocoshis SA. The Santmyer swallow: a new useful infant reflex. Lancet. 1988;1:345–6.

    Article  CAS  PubMed  Google Scholar 

  15. Spechler SJ, Castell DO. Classification of esophageal motility abnormalities. Gut. 2001;49:145–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Pandolfino JE, Kahrilas PJ. AGA technical review on the clinical use of esophageal manometry. Gastroenterology. 2005;128:209–24.

    Article  PubMed  Google Scholar 

  17. Nayar DS, Khandwala F, Achkar E, et al. Esophageal manometry: assessment of interpreter consistency. Clin Gastroenterol Hepatol. 2005;3:218–24.

    Article  PubMed  Google Scholar 

  18. Reidel WL, Clouse RE. Variations in clinical presentation of patients with esophageal contraction abnormalities. Dig Dis Sci. 1985;30:1065–71.

    Article  CAS  PubMed  Google Scholar 

  19. Achem SR, Crittenden J, Kolts B, et al. Long-term clinical and manometric follow-up of patients with nonspecific esophageal motor disorders. Am J Gastroenterol. 1992;87:825–30.

    CAS  PubMed  Google Scholar 

  20. Swift GL, Alban-Davies H, McKirdy H, et al. A long-term clinical review of patients with esophageal pain. Q J Med. 1991;81:937–44.

    CAS  PubMed  Google Scholar 

  21. Ghosh SK, Janiak P, Schwizer W, Hebbard GS, Brasseur JG. Physiology of the esophageal pressure transition zone: separate contraction waves above and below. Am J Physiol Gastrointest Liver Physiol. 2006;290:G568–76.

    Article  CAS  PubMed  Google Scholar 

  22. Staiano A, Boccia G, Miele E, Clouse RE. Segmental characteristics of esophageal peristalsis in paediatric patients. Neurogastroenterol Motil. 2008;20:19–26.

    CAS  PubMed  Google Scholar 

  23. Clouse RE, Staiano A. Topography of the esophageal peristaltic pressure wave. Am J Physiol. 1991;261:G677–84.

    CAS  PubMed  Google Scholar 

  24. Clouse RE, Staiano A. Topography of esophageal motility in patients with normal and high-amplitude esophageal peristalsis. Am J Physiol. 1993;265:G1098–107.

    CAS  PubMed  Google Scholar 

  25. Clouse RE, Alrakawi A, Staiano A. Intersubject and interswallow variability in the topography of esophageal motility. Dig Dis Sci. 1998;43:1978–85.

    Article  CAS  PubMed  Google Scholar 

  26. Staiano A, Boccia G, Salvia G, Zappulli D, Clouse RE. Development of esophageal peristalsis in preterm and term neonates. Gastroenterology. 2007;132:1718–25.

    Article  PubMed  Google Scholar 

  27. Fox M, Menne D, Stutz B, Fried M, Schwizer W. The effects of tegaserod on esophageal function and bolus transport in healthy volunteers: studies using concurrent high-resolution manometry and videofluoroscopy. Aliment Pharmacol Ther. 2006;24:1017–27.

    Article  CAS  PubMed  Google Scholar 

  28. Goldani HA, Staiano A, Borrelli O, Thapar N, Lindley KJ. Pediatric esophageal high-resolution manometry: utility of a standard protocol and size-adjusted pressure topography parameters. Am J Gastroenterol. 2010;105:460–7.

    Article  PubMed  Google Scholar 

  29. Breumelhof R, Timmer R, van Hees PA, Obertop H, Smout AJ. Low-amplitude distal esophageal spasm as a cause of severe dysphagia for solid food. Am J Gastroenterol. 1996;91:143–6.

    CAS  PubMed  Google Scholar 

  30. Pouderoux P, Shi G, Tatum RP, Kahrilas PJ. Esophageal solid bolus transit: studies using concurrent videofluoroscopy and manometry. Am J Gastroenterol. 1999;94:1457–63.

    Article  CAS  PubMed  Google Scholar 

  31. Kahrilas PJ, Ghosh SK, Pandolfino JE. Esophageal motility disorders in terms of pressure topography: the Chicago Classification. J Clin Gastroenterol. 2008;42:627–35.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Pandolfino JE, Ghosh SK, Rice J, Clarke JO, Kwiatek MA, Kahrilas PJ. Classifying esophageal motility by pressure topography characteristics: a study of 400 patients and 75 controls. Am J Gastroenterol. 2008;103:27–37.

    Article  PubMed  Google Scholar 

  33. Ghosh SK, Pandolfino JE, Zhang Q, Jarosz A, Shah N, Kahrilas PJ. Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteers. Am J Physiol Gastrointest Liver Physiol. 2006;290:G988–97.

    Article  CAS  PubMed  Google Scholar 

  34. Pandolfino JE, Ghosh SK, Zhang Q, Jarosz A, Shah N, Kahrilas PJ. Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteers. Am J Physiol Gastrointest Liver Physiol. 2006;290:G1033–40.

    Article  CAS  PubMed  Google Scholar 

  35. Ghosh SK, Pandolfino JE, Rice J, Clarke JO, Kwiatek M, Kahrilas PJ. Impaired deglutitive EGJ relaxation in clinical esophageal manometry: a quantitative analysis of 400 patients and 75 controls. Am J Physiol Gastrointest Liver Physiol. 2007;293:G878–85.

    Article  CAS  PubMed  Google Scholar 

  36. Fox M. High resolution manometry—an introduction. London: Guy’s and St Thomas’ NHS Foundation Trust; 2006. p. 1–10.

    Google Scholar 

  37. Fox M, Hebbard G, Janiak P, Brasseur JG, Ghosh S, Thumshirn M, Fried M, Schwizer W. High-resolution manometry predicts the success of esophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry. Neurogastroenterol Motil. 2004;16:533–42.

    Article  CAS  PubMed  Google Scholar 

  38. Tutuian R, Castell DO. Combined multichannel intraluminal impedance and manometry clarifies esophageal function abnormalities: study in 350 patients. Am J Gastroenterol. 2004;99:1011–9.

    Article  PubMed  Google Scholar 

  39. Staiano A, Clouse RE. Detection of incomplete lower esophageal sphincter relaxation with conventional point-pressure sensors. Am J Gastroenterol. 2001;96:3258–67.

    Article  CAS  PubMed  Google Scholar 

  40. Clouse RE, Staiano A, Alrakawi A, Haroian L. Application of topographical methods to clinical esophageal manometry. Am J Gastroenterol. 2000;95:2720–30.

    Article  CAS  PubMed  Google Scholar 

  41. Williams RB, Pal A, Brasseur JG, Cook IJ. Space-time pressure structure of pharyngo-esophageal segment during swallowing. Am J Physiol Gastrointest Liver Physiol. 2001;281:G1290–300.

    CAS  PubMed  Google Scholar 

  42. Jolley SG, Johnson DG, Roberts CC, Herbst JJ, Matlak ME, McCombs A, Christian P. Patterns of gastroesophageal reflux in children following repair of esophageal atresia and distal tracheo-esophageal fistula. J Pediatr Surg. 1980;15:857–62.

    Article  CAS  PubMed  Google Scholar 

  43. Cheng W, Poon KH, Lui VCH, Yong JL, Law S, So KT, et al. Esophageal atresia and achalasia-like esophageal dysmotility. J Pediatr Surg. 2004;39:1581–3.

    Article  CAS  PubMed  Google Scholar 

  44. Dutta HK, Grover VP, Dwivedi SN, Bhatnagar V. Manometric evaluation of postoperative patients of esophageal atresia and tracheo-esophageal fistula. Eur J Pediatr Surg. 2001;11:371–6.

    Article  CAS  PubMed  Google Scholar 

  45. Ceriati E, De Peppo F, Ciprandi G, Marchetti P, Silveri M, Rivosecchi M. Surgery in disabled children: general gastroenterological aspects. Acta Paediatr Suppl. 2006;95:34–7.

    Article  PubMed  Google Scholar 

  46. Dent J, Holloway RH, Toouli J, Dodds WJ. Mechanisms of lower esophageal sphincter incompetence in patients with symptomatic gastroesophageal reflux. Gut. 1988;29:1020–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Dent J, Dodds WJ, Friedman RH, Sekiguchi T, Hogan WJ, Arndorfer RC, et al. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest. 1980;65:256–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Mittal RK, Holloway RH, Penagini R, Blackshaw LA, Dent J. Transient lower esophageal sphincter relaxation. Gastroenterology. 1995;109:601–10.

    Article  CAS  PubMed  Google Scholar 

  49. Werlin SL, Dodds WJ, Hogan WJ, Arndorfer RC. Mechanisms of gastroesophageal reflux in children. J Pediatr. 1980;97:244–9.

    Article  CAS  PubMed  Google Scholar 

  50. Cucchiara S, Bortolotti M, Minella R, Auricchio S. Fasting and postprandial mechanisms of gastroesophageal reflux in children with gastroesophageal reflux disease. Dig Dis Sci. 1993;38:86–92.

    Article  CAS  PubMed  Google Scholar 

  51. Kawahara H, Dent J, Davidson G. Mechanisms responsible for gastroesophageal reflux in children. Gastroenterology. 1997;113:399–408.

    Article  CAS  PubMed  Google Scholar 

  52. Pensabene L, Miele E, Del Giudice E, Strisciuglio C, Staiano A. Mechanisms of gastroesophageal reflux in children with sequelae of birth asphyxia. Brain Dev. 2008;30:563–71.

    Article  PubMed  Google Scholar 

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Turco, R., Staiano, A. (2017). Esophageal Manometry. In: Faure, C., Thapar, N., Di Lorenzo, C. (eds) Pediatric Neurogastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-43268-7_7

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  • DOI: https://doi.org/10.1007/978-3-319-43268-7_7

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