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Cyclic Vomiting Syndrome: Comorbidities and Treatment

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Pediatric Neurogastroenterology

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Abstract

Cyclic vomiting syndrome (CVS) diagnosis has been facilitated by the recently defined consensus diagnostic criteria by NASPGHAN (2008), Rome III (2006), Rome IV, and International Headache Society (2013) criteria. This chapter focuses on the most recent data on comorbidities and clinical subphenotypes, pathophysiologic pathways, and new therapeutic avenues. Despite improved characterization, recognition, and understanding of CVS in the past two decades, without a delineated pathophysiologic cascade, it remains classified as a functional gastrointestinal disorder. Although originally perceived to be a pediatric disorder, the past decade has been witness to a dramatic rise in diagnosed adults. In both children and adults, the hallmark symptoms described by Samuel Gee in 1882 remain applicable today and include stereotypical, severe episodes of vomiting punctuating symptom-free periods, or baseline health [1]. Recent work has begun to expand the list of comorbidities and clinical subphenotypes and identify pathophysiologic pathways and new therapeutic avenues.

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Acknowledgment

We would like to acknowledge Dr. Bhanu Sunku who contributed substantively to the chapter in the previous edition.

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Authors and Affiliations

  1. Division of Gastroenterology, Hepatology and Nutrition, Pediatrics Department, Medical College of Wisconsin/Children’s Hospital of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA

    B. U. K. Li M.D. & Katja Kovacic M.D.

Authors
  1. B. U. K. Li M.D.
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  2. Katja Kovacic M.D.
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Corresponding author

Correspondence to B. U. K. Li M.D. .

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Editors and Affiliations

  1. Division of Pediatric Gastroenterology Hepatology and Nutrition, CHU Sainte-Justine, Montreal, Québec, Canada

    Christophe Faure

  2. Department of Paediatric Gastroenterology, UCL Institute of Child Health, London, United Kingdom

    Nikhil Thapar

  3. Division of Pediatric Gastroenterology Hepatology, and Nutrition, Nationwide Children’s Hospital, Columbus, Ohio, USA

    Carlo Di Lorenzo

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Li, B.U.K., Kovacic, K. (2017). Cyclic Vomiting Syndrome: Comorbidities and Treatment. In: Faure, C., Thapar, N., Di Lorenzo, C. (eds) Pediatric Neurogastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-43268-7_39

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  • DOI: https://doi.org/10.1007/978-3-319-43268-7_39

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-43266-3

  • Online ISBN: 978-3-319-43268-7

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