What Chemotherapy Is Practicable in Aged Patients?

  • Carmelo Pozzo
  • Ernesto Rossi


The number of elderly patients diagnosed with rectal cancer (RC) is very high and, considering colon and rectal cancer (CRC), is one of the leading causes of cancer-related death in the elderly [1]. However, the number of older patients enrolled in clinical trials is underrepresented and in most cases elderly population undertreated. Although, with the introduction of new treatments and better diagnostic techniques and surgical procedures, a better outcome is achievable today also in elderly patients diagnosed with resectable or metastatic rectal cancer, overall survival rate remains low. This is probably due to less aggressive diagnostic evaluation; less intensive chemotherapy, including anticipatory drug dose reduction or empiric schedule alteration; less aggressive surgery; and, finally yet importantly, also social conditions and limited access to healthcare system of elderly population with cancer.


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© Springer-Verlag Berlin Heidelberg 2018

Authors and Affiliations

  1. 1.Oncolgia Medica, Fondazione Policlinico A. GemelliUniversità Cattolica del Sacro CuoreRomeItaly

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