Will Adjuvant Chemotherapy Improve Outcome After Preoperative (Chemo) Radiotherapy? Still More Passion than Evidence

  • Peter Nygren
  • Bengt Glimelius


Recent data from randomised trials investigating the effect of adjuvant chemotherapy following (chemo)radiotherapy and surgery in rectal cancer are strictly interpreted negative. Thus, the default setting is to not recommend such treatment. However, based on meta- and subgroup analyses as well as incorporation of expert knowledge and experience in this field, it is reasonable to discuss adjuvant chemotherapy with patients having some defined characteristics and involve the patients in a shared decision-making. Studies ongoing will tell whether systemic chemotherapy in the neoadjuvant setting is a better approach.


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© Springer-Verlag Berlin Heidelberg 2018

Authors and Affiliations

  1. 1.Department of Immunology, Genetics and PathologyUppsala UniversityUppsalaSweden

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