Could New Drugs Offer Opportunities to Extend Resectability in Advanced Presentations?

Chapter

Abstract

Despite the significant improvements in metastatic colorectal cancer (MCRC) increasing median overall survival to 2.5 years, the majority of patients will die during the course of the disease, and new treatment approaches are urgently required. The following paragraphs will evaluate the role of molecular alterations relevant for treatment (Fig. 38.1), namely, BRAF mutation, HER2 positivity, and microsatellite instability as well as newly licensed drugs (ramucirumab and TAS-102).

Notes

Acknowledgments

The manuscript was prepared without any funding or contributions from persons not mentioned in the authors’ section.

Conflict of Interest

AS has received honoraria from Roche, Sanofi, Merck Serono, Bayer, and Amgen and research support from Roche and Sanofi.

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© Springer-Verlag Berlin Heidelberg 2018

Authors and Affiliations

  1. 1.Department of Oncology, Haematology, Stem Cell Transplantation with the section Pneumology, Hubertus Wald Tumor Centre University Cancer Centre HamburgUniversity Medical Centre Hamburg-EppendorfHamburgGermany
  2. 2.Department for Oncology-HaematologyMartin Luther University Halle–WittenbergHalleGermany

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