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Multidisciplinary Management of Rectal Cancer pp 287–297Cite as

Should Upfront Chemotherapy Precede Preoperative Chemoradiotherapy and Surgery in Locally Advanced Rectal Cancer?

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Abstract

Treatment of micrometastasis should now be the focus of major interest in the treatment of locally advanced rectal cancer because distant metastases remain the leading cause of mortality in this population. In stage II and III rectal cancer, even in modern series, after preoperative treatment with short-course radiotherapy (SCRT) or chemoradiation (CRT) and total mesorectal excision (TME) with or without adjuvant chemotherapy (CT), 5-year distant relapse is about 35%, and local relapses are about 8% [1]. However, the role of adjuvant CT after CRT is still controversial.

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Author information

Authors and Affiliations

  1. Fundacion Instituto Valenciano de Oncologia, Valencia, Spain

    Carlos Fernandez-Martos

  2. Hospital General Universitario Elche, Alicante, Spain

    Javier Gallego

  3. University of Florida Health Cancer Center, Gainesville, FL, USA

    Thomas J George

Authors
  1. Carlos Fernandez-Martos
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  2. Javier Gallego
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  3. Thomas J George
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Corresponding author

Correspondence to Carlos Fernandez-Martos .

Editor information

Editors and Affiliations

  1. Dept. of Radiation Oncology, Università Cattolica S Cuore, Rome, Italy

    Vincenzo Valentini

  2. Head, Div. Clinical Oncology Research, University Clinic Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Sachsen-Anhalt, Germany

    Hans-Joachim Schmoll

  3. Department of Surgery, Leiden Univ Med Ctr, Leiden, The Netherlands

    Cornelis J. H. van de Velde

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Fernandez-Martos, C., Gallego, J., George, T.J. (2018). Should Upfront Chemotherapy Precede Preoperative Chemoradiotherapy and Surgery in Locally Advanced Rectal Cancer?. In: Valentini, V., Schmoll, HJ., van de Velde, C. (eds) Multidisciplinary Management of Rectal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-43217-5_37

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  • DOI: https://doi.org/10.1007/978-3-319-43217-5_37

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  • Print ISBN: 978-3-319-43215-1

  • Online ISBN: 978-3-319-43217-5

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