When Should IGRT Be Done?
The therapeutic window of radiotherapy is defined by the balance between the tumor control probability (TCP) and the normal tissue complication probability (NTCP). The tremendous evolution from bony-landmark two-dimensional radiotherapy over CT-based three-dimensional radiotherapy towards highly-conformal radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) has broadened the therapeutic window substantially.
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