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Are There New Molecular Imaging Modalities Behind the Corner?

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Multidisciplinary Management of Rectal Cancer

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Abstract

The diagnostic work-up of locally advanced rectal cancer (LARC) has also changed thanks to recent advances in positron emission tomography-computed tomography (PET-CT) and its increasing availability. Several studies showed that FDG PET-CT accurately changed the stage with a subsequent alteration in therapy in almost one-third of patients. Moreover, FDG PET-CT capable to predict the effect of preoperative chemoradiation as well as survival.

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References

  1. Davey K, Heriot A, Mackay J, Drummond E, Hogg A, Ngan S, Milner A, Hicks R (2008) The impact of 18-fluorodeoxyglucose positron emission tomography-computed tomography on the staging and management of primary rectal cancer. Dis Colon Rectum 51(7):997–1003

    Article  CAS  PubMed  Google Scholar 

  2. Deleau C, Buechera B, Rousseauc C, Kraeber-Bode F, Flamanta M, des Varannesa SB, Frampasb E, Galmichea J-P, Matysiak-Budnika T (2011) Clinical impact of fluorodeoxyglucose-positron emission tomography scan/computed tomography in comparison with computed tomography on the detection of colorectal cancer recurrence. Eur J Gastroenterol Hepatol 23:275–281

    Article  PubMed  Google Scholar 

  3. Coenegrachts K, De Geeter F, ter Beek L, Walgraeve N, Bipat S, Stoker J, Rigauts H (2009) Comparison of MRI (including SS SE-EPI and SPIO-enhanced MRI) and FDG-PET/CT for the detection of colorectal liver metastases. Eur Radiol 19(2):370–379

    Article  PubMed  Google Scholar 

  4. Kong G, Jackson C, Koh D, Lewington V, Sharma B, Brown G, Cunningham D, Cook G (2008) The use of 18F-FDG PET/CT in colorectal liver metastases-comparison with CT and liver MRI. Eur J Nucl Med Mol Imaging 35(7):1323–1329

    Article  CAS  PubMed  Google Scholar 

  5. Leccisotti L, Gambacorta MA, de Waure C, Stefanelli A, Barbaro B, Vecchio FM, Coco C, Persiani R, Crucitti A, Tortorelli AP, Giordano A, Valentini V (2015) The predictive value of 18F-FDG PET/CT for assessing pathological response and survival in locally advanced rectal cancer after neoadjuvant radiochemotherapy. Eur J Nucl Med Mol Imaging 42(5):657–666

    Article  CAS  PubMed  Google Scholar 

  6. Ryan JE, Warrier SK, Lynch AC, Heriot AG (2015) Assessing pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a systematic review. Colorectal Dis 17:849–861

    Article  CAS  PubMed  Google Scholar 

  7. Maffione AM, Marzola MC, Capirci C, Colletti PM, Rubello D (2015) Value of (18)F-FDG PET for predicting response to neoadjuvant therapy in rectal cancer: systematic review and meta-analysis. AJR Am J Roentgenol 204(6):1261–1268

    Article  PubMed  Google Scholar 

  8. Joye I, Deroose CM, Vandecaveye V, Haustermans K (2014) The role of diffusion-weighted MRI and (18)F-FDG PET/CT in the prediction of pathologic complete response after radiochemotherapy for rectal cancer: a systematic review. Radiother Oncol 113(2):158–165

    Article  PubMed  Google Scholar 

  9. Maffione AM, Chondrogiannis S, Capirci C, Galeotti F, Fornasiero A, Crepaldi G, Grassetto G, Rampin L, Marzola MC, Rubello D (2014) Early prediction of response by 18F-FDG PET/CT during preoperative therapy in locally advanced rectal cancer: a systematic review. Eur J Surg Oncol 40(10):1186–1194

    Article  CAS  PubMed  Google Scholar 

  10. Memon S, Lynch AC, Akhurst T, Ngan SY, Warrier SK, Michael M, Heriot AG (2014) Systematic review of FDG-PET prediction of complete pathological response and survival in rectal cancer. Ann Surg Oncol 21(11):3598–3607

    Article  PubMed  Google Scholar 

  11. van Stiphout RG, Valentini V, Buijsen J, Lammering G, Meldolesi E, van Soest J, Leccisotti L, Giordano A, Gambacorta MA, Dekker A, Lambin P (2014) Nomogram predicting response after chemoradiotherapy in rectal cancer using sequential PETCT imaging: a multicentric prospective study with external validation. Radiother Oncol 113(2):215–222

    Article  PubMed  Google Scholar 

  12. Paspulati RM, Partovi S, Herrmann KA, Krishnamurthi S, Delaney CP, Nguyen NC (2015) Comparison of hybrid FDG PET/MRI compared with PET/CT in colorectal cancer staging and restaging: a pilot study. Abdom Imaging 40(6):1415–1425

    Article  PubMed  Google Scholar 

  13. Roels S, Slagmolen P, Nuyts J et al (2008) Biological image guided radiotherapy in rectal cancer: is there a role for FMISO or FLT, next to FDG? Acta Oncol 47:1237–1248

    Article  CAS  PubMed  Google Scholar 

  14. Dietz D, Dehdashti F, Grigsby P, Malyapa R, Myerson R, Picus J, Ritter J, Lewis J, Welch M, Siegel B (2008) Tumor hypoxia detected by positron emission tomography with 60Cu-ATSM as a predictor of response and survival in patients undergoing neoadjuvant chemoradiotherapy for rectal carcinoma: a pilot study. Dis Colon Rectum 51(11):1641–1648

    Article  PubMed  PubMed Central  Google Scholar 

  15. Francis DL, Freeman A, Visvikis D et al (2003) In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography. Gut 52:1602–1606

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Muijs CT, Beukema JC, Widder J, van den Bergh ACM, Havenga K, Pruim J, Langendijk JA (2011) 18F-FLT-PET for detection of rectal cancer. Radiother Oncol 98(3):357–359

    Article  PubMed  Google Scholar 

  17. Wieder H, Geinitz H, Rosenberg R, Lordick F, Becker K, Stahl A, Rummeny E, Siewert J, Schwaiger M, Stollfuss J (2007) PET imaging with [18F]3′-deoxy-3′-fluorothymidine for prediction of response to neoadjuvant treatment in patients with rectal cancer. Eur J Nucl Med Mol Imaging 34(6):878–883

    Article  CAS  PubMed  Google Scholar 

  18. Yang SY, Sales KM, Fuller B, Seifalian AM, Winslet MC (2009) Apoptosis and colorectal cancer: implications for therapy. Trends Mol Med 15:225–233

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. PET-CT Centre, Fondazione Pol. Universitario A. Gemelli, Rome, Italy

    Lucia Leccisotti

  2. Institute of Nuclear Medicine, Università Cattolica del Sacro Cuore, Rome, Italy

    Antonella Stefanelli

Authors
  1. Lucia Leccisotti
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  2. Antonella Stefanelli
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Corresponding author

Correspondence to Lucia Leccisotti .

Editor information

Editors and Affiliations

  1. Dept. of Radiation Oncology, Università Cattolica S Cuore, Rome, Italy

    Vincenzo Valentini

  2. Head, Div. Clinical Oncology Research, University Clinic Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Sachsen-Anhalt, Germany

    Hans-Joachim Schmoll

  3. Department of Surgery, Leiden Univ Med Ctr, Leiden, The Netherlands

    Cornelis J. H. van de Velde

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Leccisotti, L., Stefanelli, A. (2018). Are There New Molecular Imaging Modalities Behind the Corner?. In: Valentini, V., Schmoll, HJ., van de Velde, C. (eds) Multidisciplinary Management of Rectal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-43217-5_16

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  • DOI: https://doi.org/10.1007/978-3-319-43217-5_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-43215-1

  • Online ISBN: 978-3-319-43217-5

  • eBook Packages: MedicineMedicine (R0)

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