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What Is Cancer of the Rectum?

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Multidisciplinary Management of Rectal Cancer

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Abstract

Rectal cancer constitutes one-third of all colorectal cancers, representing the cancer with the second highest incidence and the second cause of cancer death in the western society [1, 2]. An estimated 100,000 new cases of rectal cancer are diagnosed each year in Europe. The incidence is increasing, mainly due to earlier detection and increasing age of the population, as the highest incidence of rectal cancer is found in the sixth and seventh decades. High incidence rates are found especially in western world populations, i.e. Western Europe, North America and Australia. This can probably be explained by a combination of factors, including dietary patterns with high amounts of red meat, obesity and smoking [3]. The United States is the only country with significantly decreasing incidence rates in both males and females in the most recent time period, which largely reflects detection and removal of precancerous lesions through colorectal cancer screening [4]. Next to dietary and life-style factors, risk factors for rectal cancer include inflammatory bowel disease and primary sclerosing cholangitis. Also genetic predisposition plays a role; however, rectal cancer most commonly occurs sporadically and is inherited in only 5% of the cases. Five-year survival rate of rectal cancer is about 60% and depends to a large extent on disease stage at diagnosis [5].

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References

  1. Ferlay J et al (2007) Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 18:581–592

    Article  CAS  PubMed  Google Scholar 

  2. Boyle P, Ferlay J (2005) Cancer incidence and mortality in Europe, 2004. Ann Oncol 16:481–488

    Article  CAS  PubMed  Google Scholar 

  3. Jemal A et al (2011) Global cancer statistics. CA Cancer J Clin 61:69–90

    Article  PubMed  Google Scholar 

  4. Edwards BK et al (2010) Annual report to the nation on the status of cancer, 1975–2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 116:544–573

    Article  PubMed  PubMed Central  Google Scholar 

  5. Zampino MG et al (2004) Rectal cancer. Crit Rev Oncol Hematol 51:121–143

    Article  PubMed  Google Scholar 

  6. Lange MM, van de Velde CJ (2008) Faecal and urinary incontinence after multimodality treatment of rectal cancer. PLoS Med 5:e202

    Article  PubMed  PubMed Central  Google Scholar 

  7. Lange MM, van de Velde CJ (2011) Urinary and sexual dysfunction after rectal cancer treatment. Nat Rev Urol 8:51–57

    Article  PubMed  Google Scholar 

  8. Martling A, Holm T, Johansson H, Rutqvist LE, Cedermark B (2001) The Stockholm II trial on preoperative radiotherapy in rectal carcinoma: long-term follow-up of a population-based study. Cancer 92:896–902

    Article  CAS  PubMed  Google Scholar 

  9. Kapiteijn E et al (1999) Total mesorectal excision (TME) with or without preoperative radiotherapy in the treatment of primary rectal cancer. Prospective randomised trial with standard operative and histopathological techniques. Dutch ColoRectal Cancer Group. Eur J Surg 165:410–420

    Article  CAS  PubMed  Google Scholar 

  10. Czito BG, Willett CG (2010) Rectal cancer: international perspectives on multimodality management. Humana Press, New York

    Book  Google Scholar 

  11. Lange JF, Kleinrensink GJ (2002) Surgical anatomy of the abdomen. Elsevier, Maarssen

    Google Scholar 

  12. Kraima AC, West NP, Treanor D, Magee DR, Rutten HJ, Quirke P, DeRuiter MC, van de Velde CJ (2015) Whole mount microscopic sections reveal that Denonvilliers’ fascia is one entity and adherent to the mesorectal fascia; implications for the anterior plane in total mesorectal excision? Eur J Surg Oncol 41(6):738–745

    Article  CAS  PubMed  Google Scholar 

  13. Heald RJ (1979) A new approach to rectal cancer. Br J Hosp Med 22:277–281

    CAS  PubMed  Google Scholar 

  14. Kusters M et al (2010) Origin of presacral local recurrence after rectal cancer treatment. Br J Surg 97:1582–1587

    Article  CAS  PubMed  Google Scholar 

  15. Kraima AC, van Schaik J, Susan S, van de Velde CJ, Hamming JF, Lakke EA, DeRuiter MC (2015) New insights in the neuroanatomy of the human adult superior hypogastric plexus and hypogastric nerves. Autonom Neurosci 189:60–67

    Article  Google Scholar 

  16. Wallner C et al (2008) The contribution of the levator ani nerve and the pudendal nerve to the innervation of the levator ani muscles; a study in human fetuses. Eur Urol 54:1136–1142

    Article  PubMed  Google Scholar 

  17. Lange MM et al (2007) Risk factors for faecal incontinence after rectal cancer treatment. Br J Surg 94:1278–1284

    Article  CAS  PubMed  Google Scholar 

  18. Wallner C et al (2008) Causes of fecal and urinary incontinence after total mesorectal excision for rectal cancer based on cadaveric surgery: a study from the cooperative clinical investigators of the Dutch total mesorectal excision trial. J Clin Oncol 26:4466–4472

    Article  PubMed  Google Scholar 

  19. Conlin A, Smith G, Carey FA, Wolf CR, Steele RJ (2005) The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma. Gut 54:1283–1286

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Vogelstein B et al (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319:525–532

    Article  CAS  PubMed  Google Scholar 

  21. Nilbert M, Planck M, Fernebro E, Borg A, Johnson A (1999) Microsatellite instability is rare in rectal carcinomas and signifies hereditary cancer. Eur J Cancer 35:942–945

    Article  CAS  PubMed  Google Scholar 

  22. Frattini M et al (2004) Different genetic features associated with colon and rectal carcinogenesis. Clin Cancer Res 10:4015–4021

    Article  CAS  PubMed  Google Scholar 

  23. Dimberg J, Samuelsson A, Hugander A, Soderkvist P (1999) Differential expression of cyclooxygenase 2 in human colorectal cancer. Gut 45:730–732

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Takeichi M (1991) Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251:1451–1455

    Google Scholar 

  25. Sinicrope FA et al (1996) Increased apoptosis accompanies neoplastic development in the human colorectum. Clin Cancer Res 2:1999–2006

    CAS  PubMed  Google Scholar 

  26. Cripps H (1890) On diseases of the rectum and the anus. J&A Churchill, London

    Google Scholar 

  27. Miles WE (1971) A method of performing abdomino-perineal excision for carcinoma of the rectum and of the terminal portion of the pelvic colon (1908). CA Cancer J Clin 21:361–364

    Article  CAS  PubMed  Google Scholar 

  28. MacKay GJ, Dorrance HR, Richard GM, O’Dwyer PJ (2010) Colorectal surgery. Oxford University Press, Oxford

    Book  Google Scholar 

  29. Wibe A et al (2002) Prognostic significance of the circumferential resection margin following total mesorectal excision for rectal cancer. Br J Surg 89:327–334

    Article  CAS  PubMed  Google Scholar 

  30. Lahaye MJ et al (2005) Imaging for predicting the risk factors – the circumferential resection margin and nodal disease – of local recurrence in rectal cancer: a meta-analysis. Semin Ultrasound CT MR 26:259–268

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Leiden University Medical Center (The Netherlands), Department of Surgery, Leiden, The Netherlands

    M. M. Lange, A. C. Kraima & C. J. H. van de Velde

  2. Leiden University Medical Center (The Netherlands), Department of Anatomy and Embryology, Leiden, The Netherlands

    M. C. deRuiter

Authors
  1. M. M. Lange
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  2. A. C. Kraima
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  3. C. J. H. van de Velde
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  4. M. C. deRuiter
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Corresponding author

Correspondence to C. J. H. van de Velde .

Editor information

Editors and Affiliations

  1. Dept. of Radiation Oncology, Università Cattolica S Cuore, Rome, Italy

    Vincenzo Valentini

  2. Head, Div. Clinical Oncology Research, University Clinic Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Sachsen-Anhalt, Germany

    Hans-Joachim Schmoll

  3. Department of Surgery, Leiden Univ Med Ctr, Leiden, The Netherlands

    Cornelis J. H. van de Velde

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Lange, M.M., Kraima, A.C., van de Velde, C.J.H., deRuiter, M.C. (2018). What Is Cancer of the Rectum?. In: Valentini, V., Schmoll, HJ., van de Velde, C. (eds) Multidisciplinary Management of Rectal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-43217-5_1

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  • DOI: https://doi.org/10.1007/978-3-319-43217-5_1

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  • Online ISBN: 978-3-319-43217-5

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