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Rheumatology

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Abstract

Skeletal disorders can be grouped by their etiology and pathophysiology into a variety of entities, including metabolic diseases, tumors, matrix disorders, and inflammatory conditions. The pathophysiological spectrum of chronic inflammatory disorders of bone tissue ranges from autoimmune diseases to diseases which present with autoinflammatory characteristics [31]. In general, autoinflammatory diseases are characterized by chronic inflammation without evidence of autoimmunity (e.g., autoantibodies or autoreactive T cells) and may affect various tissues, including the skeletal system [28]. Autoinflammatory bone disorders result from a dysregulation of the innate immune system with subsequent inflammatory cellular infiltration of the bone, increased osteoclast activity, osteolysis, and bone remodeling [9, 15]. Chronic/recurrent noninfectious osteomyelitis is the common denominator of all autoinflammatory bone diseases. The recurrent disease course in the absence of microorganisms at the site of inflammation and the lack of high-titer autoantibodies and/or autoreactive T lymphocytes have led to the inclusion of this disease in the group of autoinflammatory conditions.

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Authors and Affiliations

  1. Unit of Rheumatology, “Bambino Gesù” Children Hospital, Rome, Italy

    Fabrizio De Benedetti & Antonella Insalaco

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  1. Fabrizio De Benedetti
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  2. Antonella Insalaco
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Correspondence to Antonella Insalaco .

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Editors and Affiliations

  1. Diagnostic Imaging Dept-Nuclear Med, IRCCS Bambino Gesù Paediatric Hospi, Rome, Italy

    Maria Carmen Garganese

  2. Diagnostic Imaging Dept-Nucl Med Un, Private Hospital "Pio XI", Rome, Italy

    Giovanni Francesco Livio D'Errico

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De Benedetti, F., Insalaco, A. (2017). Rheumatology. In: Garganese, M., D'Errico, G. (eds) Conventional Nuclear Medicine in Pediatrics. Springer, Cham. https://doi.org/10.1007/978-3-319-43181-9_20

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  • DOI: https://doi.org/10.1007/978-3-319-43181-9_20

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