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Skin Stress Response Pathways pp 211–234Cite as

UV-Induced Chemokines as Emerging Targets for Skin Cancer Photochemoprevention

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Abstract

The ultraviolet (UV) radiation contained in sunlight is a complete carcinogen because it can damage DNA, suppress anti-tumour immunity and enhance metastasis of skin cancers. A major way in which UV affects cancer cells and anti-tumour immunity is by modulating the expression of cytokines and chemokines. Knowing this has allowed us to develop and deploy revolutionary biologics that target these UV-induced molecules. This so called “photochemoprevention” can involve topical or oral intervention by biologically active compounds that prevent or repair the damage caused by UV radiation. Many of the successful photochemoprevention strategies involve protection from UV induction of chemokines and cytokines. This chapter will discuss which cutaneous cytokines/chemokines are affected by UV exposure and highlight the ways in which targeting these molecules is providing us with new therapeutic options for preventing and treating skin cancer.

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Authors and Affiliations

  1. Infectious Diseases and Immunology, Charles Perkins Centre, Sydney Medical School, University of Sydney, Level 5 (East), Charles Perkins Centre Hub (D17), Sydney, NSW, 2006, Australia

    Scott N. Byrne

  2. Dermatology Research Laboratories, Bosch Institute, Sydney Medical School, University of Sydney, Sydney, Australia

    Scott N. Byrne & Gary M. Halliday

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  1. Department of Pharmacology and Toxicology, College of Pharmacy & The University of Arizona Cancer Center, Department of Pharmacology and Toxicology, TUCSON, Arizona, USA

    Georg T. Wondrak

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Byrne, S.N., Halliday, G.M. (2016). UV-Induced Chemokines as Emerging Targets for Skin Cancer Photochemoprevention. In: Wondrak, G. (eds) Skin Stress Response Pathways. Springer, Cham. https://doi.org/10.1007/978-3-319-43157-4_10

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