Pain Medicine pp 157-158 | Cite as


  • Robert M. ChowEmail author
  • Mohammed Issa


Methadone is commonly used for treatment of chronic pain and opioid addiction (only by specially licensed facilities). Its unique pharmacokinetic and pharmacodynamic properties (half-life of 24–60 h), high oral bioavailability (40–99 %), absence of active metabolites, and its relatively low cost make it an attractive alternative to other opioids in special circumstances.


Chronic pain Agonist Drug interactions Dosage Weaning 

Suggested Reading

  1. 1.
    Singh N, et al. Methadone for chronic pain. In: Comprehensive treatment of chronic pain by medical, interventional and integrative approaches. New York, NY: Springer; 2013. p. 145–50.CrossRefGoogle Scholar
  2. 2.
    Toombs J, et al. Methadone treatment for pain states. Am Fam Physician. 2005;71:1353–8.PubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Department of AnesthesiologyUniversity of Maryland Medical CenterBaltimoreUSA
  2. 2.Department of Anesthesiology and PsychiatryBrigham and Women’s HospitalBostonUSA

Personalised recommendations