Abstract
Each chemical compound possesses numerous biological activities. Biological activity spectrum of a compound should be predicted on the basis of the structure-activity-relationships. The biological activity spectrum of a compound shows its all actions and its participation in the biological, physiological and metabolically pathways despite the difference in the experimental conditions. The biological activity spectrum of a compound shows compound’s all actions and the participation in the biological, physiological and metabolically pathways despite the difference in the experimental conditions. If the differences in species, sex, age, dose, and the participation in the metabolic processes and pathways etc. are neglected, the biological activity may be identified only qualitatively. Thus the biological activity spectrum is defined as the “intrinsic” property of a substance depending only on its structure and physicochemical characteristics. Structure-activity-relationship (SAR) is an approach to finding the relationships between the chemical structure (or structural-related properties) and the biological activity of studied compounds. It links the chemical structure to a chemical property (e.g., water solubility) or the biological activity including toxicity.
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Brown N (2012) Bioisosteres in medicinal chemistry. Wiley-VCH, Weinheim, p 237. ISBN 978-3-527-33015-7
Chirico N, Gramatica P (2012) Real external predictivity of QSAR models. Part 2. New intercomparable thresholds for different validation criteria and the need for scatter plot inspection. J Chem Inf Model 52:2044–2058. doi:10.1021/ci300084j.PMID22721530
Filimonov DA, Poroikov VV (1996) PASS: computerized prediction on biologically active spectra for chemical substances. In: Bioactive compound design. Possibilities for industrial use. Bios Scientific Publishers, Oxford, pp 47–56
Filimonov DA, Poroikov VV, Borodina Y, Gloriozova T (1999) Chemical similarity assessment through multilevel neighborhoods of atoms: definition and comparison with the other descriptors. J Chem Inf Comput Sci 39:666–670
Haider K, Martin PJ (1967) Synthesis and transformation of phenolic compounds by Epiccocum nigrum in relation to humic acids formation. Proc Soil Sci Soc Am 31:766–772
Jurs PC, Hasan MN, Rohrbaugh RH (1988) Prediction of physicochemical properties of organic compounds from molecular structure. In: Jochun C, Hicks MG, Sunkel J (eds) Physical property prediction in organic chemi- physicochemical properties of organic compounds from molecular structure. Springer, Berlin, pp 209–233
Lacy A, O’Kennedy R (2004) Studies on coumarin- related compounds to determine their therapeutic role in the treatment of cancer. Curr Pharm Des 10:3797–3811
Nantasenamat C, Isarankura-Na-Ayudhya C, Naenna T, Prachayasittikul V (2009) A practical overview of quantitative structure-activity relationship. Exp Clin Sci 8:74–88
Nantasenamat C, Isarankura-Na-Ayudhya C, Prachayasittikul V (2010) Advances in computational methods to predict the biological activity of compounds. Expert Orin Drug Discovery 5:633–654
Patani GA, LaVoie EJ (1996) Bioisosterism: a rational approach in drug design. Chem Rev 96:3147–3176
Smyk B (1992) The soil fatigue as potential threat to natural environments of terrestrial ecosystems. Acta Acad Agric Tech Olst Agric 55:17–31
Stevenson FJ (1982) Humus chemistry, genesis, composition, reactions. Wiley, New York, pp 172–194
Szajdak LW (2011) Shelterbelts: efficient element of landscape. LAP Lambert Academic Publishing, Saarbrücken, p 90
Szajdak L, Życzyńska-Bałoniak I (1994) Phenolic acids in brown soils under continuous cropping system of rye and crop rotation. Pol J Soil Sci 27:113–121
Thompson SJ, Hattotuwagama CK, Holliday JD, Flower DR (2006) On the hydrophobicity of peptides: comparing empirical predictions of peptide log P values. Bioinformation 1(7):237–241
Uosukainen H, Pihlaja K (2006) Peat in balneology and therapy. Terraviva Oy, Kempele, pp 1–96
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Szajdak, L.W. (2016). Introduction: Biologically Active Compounds. In: Szajdak, L. (eds) Bioactive Compounds in Agricultural Soils. Springer, Cham. https://doi.org/10.1007/978-3-319-43107-9_1
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DOI: https://doi.org/10.1007/978-3-319-43107-9_1
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