Abstract
The development of practical, efficient, and atom-economical methods for the formation of carbon–carbon bonds remains a topic of considerable interest in current synthetic organic chemistry. In this review, we have summarized selected topics from the recent literature with particular emphasis on C-alkylation processes involving hydrogen transfer using alcohols as alkylation reagents. This review includes selected highlights concerning recent progress towards the modification of catalytic systems for the α-alkylation of ketones, nitriles, and esters. Furthermore, we have devoted a significant portion of this review to the methylation of ketones, alcohols, and indoles using methanol. Lastly, we have also documented recent advances in β-alkylation methods involving the dimerization of alcohols (Guerbet reaction), as well as new developments in C-alkylation methods based on sp 3 C–H activation.
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This article is part of the Topical Collection “Hydrogen Transfer Reactions”; edited by Gabriela Guillena, Diego J.Ramón.
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© 2016 Springer International Publishing Switzerland
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Obora, Y. (2016). C-Alkylation by Hydrogen Autotransfer Reactions. In: Guillena, G., Ramón, D. (eds) Hydrogen Transfer Reactions. Topics in Current Chemistry Collections. Springer, Cham. https://doi.org/10.1007/978-3-319-43051-5_6
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DOI: https://doi.org/10.1007/978-3-319-43051-5_6
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Publisher Name: Springer, Cham
Print ISBN: 978-3-319-43049-2
Online ISBN: 978-3-319-43051-5
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