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Optical and Anatomic Changes in Fuchs Endothelial Dystrophy Corneas

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Current Treatment Options for Fuchs Endothelial Dystrophy

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Abstract

The advent of endothelial keratoplasty and improvements in corneal imaging have advanced our understanding of the optical and anatomic properties of corneas with Fuchs endothelial dystrophy before and after keratoplasty. Corneal changes appear earlier in the course of Fuchs endothelial dystrophy than previously considered, indicating disease chronicity, probably in response to a state of long-term subclinical corneal edema. These early changes increase optical aberrations and light scatter that decrease visual acuity and increase disability glare, respectively. Because many of the structural changes that contribute to aberrations and scatter originate in the anterior cornea, they persist in the host cornea after endothelial keratoplasty and even after corneal edema has resolved. These factors that originate early in the disease process probably determine the visual outcomes of endothelial keratoplasty for Fuchs endothelial dystrophy.

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Authors and Affiliations

  1. Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA

    Katrin Wacker MD, Jay W. McLaren PhD & Sanjay V. Patel MD, FRCOphth

  2. Eye Center, Albert-Ludwigs-University of Freiburg, Killianstr. 5, 79106, Freiburg, Germany

    Katrin Wacker MD

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Correspondence to Sanjay V. Patel MD, FRCOphth .

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  1. Department of Ophthalmology, University of Cologne, Cologne, Germany

    Claus Cursiefen

  2. Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA

    Albert S. Jun

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Wacker, K., McLaren, J.W., Patel, S.V. (2017). Optical and Anatomic Changes in Fuchs Endothelial Dystrophy Corneas. In: Cursiefen, C., Jun, A. (eds) Current Treatment Options for Fuchs Endothelial Dystrophy. Springer, Cham. https://doi.org/10.1007/978-3-319-43021-8_4

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