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Elevated cTn in Other Acute Situations Such as Atrial Fibrillation, Sepsis, Respiratory Failure, and Gastrointestinal Bleeding

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Cardiac Biomarkers

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Abstract

Prevalence of elevated hs-cTnT (above the 99th percentile) with relevant concentration changes in patients without an ACS is high, and elevated hs-cTn is associated with adverse long-term outcomes, irrespective the exact underlying reason. Differentiation between ischemic and non-ischemic reasons is particularly challenging as ischemic and non-ischemic mechanisms frequently co-exist. Understanding the etiology of troponin elevation in critically ill patients is important to better target appropriate therapies for MI in this population.

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Selected References

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    Article  PubMed  Google Scholar 

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    Article  CAS  PubMed  Google Scholar 

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    Article  PubMed  Google Scholar 

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    Article  PubMed  Google Scholar 

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    Article  PubMed  Google Scholar 

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    Article  CAS  PubMed  Google Scholar 

  • Vasile VC, Chai HS, Khambatta S, et al. Significance of elevated cardiac troponin T levels in critically ill patients with acute respiratory disease. Am J Cardiol. 2010;123:1049–58.

    CAS  Google Scholar 

  • Vasile VC, Chai HS, Abdeldayem D, et al. Elevated cardiac troponin T levels in critically ill patients with sepsis. Am J Med. 2013;126:1114–21.

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Authors and Affiliations

  1. Department of Internal Medicine III, Cardiology, University Hospital Heidelberg, Medizinische Klinik III, Heidelberg, Germany

    Evangelos Giannitsis MD & Hugo A. Katus MD

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  1. Evangelos Giannitsis MD
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  2. Hugo A. Katus MD
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Correspondence to Evangelos Giannitsis MD .

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  1. Division of Cardiovascular Medicine, University of California San Diego Division of Cardiovascular Medicine, La Jolla, California, USA

    Alan S. Maisel

  2. Cardiology Department, Mayo Clinic Cardiology Department, ROCHESTER, Minnesota, USA

    Allan S. Jaffe

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Giannitsis, E., Katus, H.A. (2016). Elevated cTn in Other Acute Situations Such as Atrial Fibrillation, Sepsis, Respiratory Failure, and Gastrointestinal Bleeding. In: Maisel, A., Jaffe, A. (eds) Cardiac Biomarkers. Springer, Cham. https://doi.org/10.1007/978-3-319-42982-3_8

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