Abstract
This chapter focuses on two major host responses recently found to be involved in CHIKV infection: autophagy and apoptosis. For each process, we first present molecular pathways and associated signalling, then we highlight the diverse strategies developed by host cells to prevent viral replication and virus-induced cell death, as well as by the virus to fight and hijack these host cell defence pathways.
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References
Behrends C, Fulda S (2012) Receptor proteins in selective autophagy. Int J Cell Biol 2012:673290. doi:10.1155/2012/673290
Bourai M, Lucas-Hourani M, Gad HH, Drosten C, Jacob Y, Tafforeau L et al (2012) Mapping of chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component. J Virol 86(6):3121–3134. doi:10.1128/JVI.06390-11
Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK et al (2008) A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456(7219):259–263. doi:10.1038/nature07416
Chan EY (2009) mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex. Sci Signal 2(84), e51. doi:10.1126/scisignal.284pe51
Chiramel AI, Brady NR, Bartenschlager R (2013) Divergent roles of autophagy in virus infection. Cells 2(1):83–104. doi:10.3390/cells2010083
Choi AM, Ryter SW, Levine B (2013) Autophagy in human health and disease. N Engl J Med 368(19):1845–1846. doi:10.1056/NEJMc1303158
Deretic V, Saitoh T, Akira S (2013) Autophagy in infection, inflammation and immunity. Nat Rev Immunol 13(10):722–737. doi:10.1038/nri3532
Dong X, Levine B (2013) Autophagy and viruses: adversaries or allies? J Innate Immun 5(5):480–493. doi:10.1159/000346388
Everett H, McFadden G (1999) Apoptosis: an innate immune response to virus infection. Trends Microbiol 7(4):160–165
Filomeni G, De Zio D, Cecconi F (2014) Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ 22(3):377–388. doi:10.1038/cdd.2014.150
Garmashova N, Gorchakov R, Frolova E, Frolov I (2006) Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcription. J Virol 80(12):5686–5696. doi:10.1128/JVI.02739-05
Garmashova N, Gorchakov R, Volkova E, Paessler S, Frolova E, Frolov I (2007) The Old World and New World alphaviruses use different virus-specific proteins for induction of transcriptional shutoff. J Virol 81(5):2472–2484. doi:10.1128/JVI.02073-06
Geng J, Klionsky DJ (2008) The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein modifications: beyond the usual suspects’ review series. EMBO Rep 9(9):859–864. doi:10.1038/embor.2008.163
Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N et al (2013) Autophagosomes form at ER-mitochondria contact sites. Nature 495(7441):389–393. doi:10.1038/nature11910
Hetz C (2012) The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 13(2):89–102. doi:10.1038/nrm3270
Joubert PE, Werneke SW, de la Calle C, Guivel-Benhassine F, Giodini A, Peduto L et al (2012) Chikungunya virus-induced autophagy delays caspase-dependent cell death. J Exp Med 209(5):1029–1047. doi:10.1084/jem.20110996
Judith D, Mostowy S, Bourai M, Gangneux N, Lelek M, Lucas-Hourani M et al (2013) Species-specific impact of the autophagy machinery on chikungunya virus infection. EMBO Rep 14(6):534–544. doi:10.1038/embor.2013.51
Kepp O, Senovilla L, Galluzzi L, Panaretakis T, Tesniere A, Schlemmer F et al (2009) Viral subversion of immunogenic cell death. Cell Cycle 8(6):860–869
Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26(4):239–257
Kirkin V, McEwan DG, Novak I, Dikic I (2009) A role for ubiquitin in selective autophagy. Mol Cell 34(3):259–269. doi:10.1016/j.molcel.2009.04.026
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K et al (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8(4):445–544
Krejbich-Trotot P, Gay B, Li-Pat-Yuen G, Hoarau JJ, Jaffar-Bandjee MC, Briant L et al (2011) Chikungunya triggers an autophagic process which promotes viral replication. Virol J 8:432. doi:10.1186/1743-422X-8-432
Kroemer G, Galluzzi L, Brenner C (2007) Mitochondrial membrane permeabilization in cell death. Physiol Rev 87(1):99–163. doi:10.1152/physrev.00013.2006
Kuma A, Mizushima N (2010) Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism. Semin Cell Dev Biol 21(7):683–690. doi:10.1016/j.semcdb.2010.03.002
Kurokawa M, Kornbluth S (2009) Caspases and kinases in a death grip. Cell 138(5):838–854. doi:10.1016/j.cell.2009.08.021
Lamb CA, Yoshimori T, Tooze SA (2013) The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol 14(12):759–774. doi:10.1038/nrm3696
Li ML, Stollar V (2004) Alphaviruses and apoptosis. Int Rev Immunol 23(1–2):7–24
Mizushima N (2010) The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 22(2):132–139. doi:10.1016/j.ceb.2009.12.004
Mizushima N, Yoshimori T, Ohsumi Y (2011) The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol 27:107–132. doi:10.1146/annurev-cellbio-092910-154005
Mostowy S, Cossart P (2012) Bacterial autophagy: restriction or promotion of bacterial replication? Trends Cell Biol 22(6):283–291. doi:10.1016/j.tcb.2012.03.006
Munz C (2013) Macroautophagy—friend or foe of viral replication? EMBO Rep 14(6):483–484. doi:10.1038/embor.2013.55
Orvedahl A, MacPherson S, Sumpter R Jr, Talloczy Z, Zou Z, Levine B (2010) Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Microbe 7(2):115–127. doi:10.1016/j.chom.2010.01.007
Rosen A, Casciola-Rosen L, Ahearn J (1995) Novel packages of viral and self-antigens are generated during apoptosis. J Exp Med 181(4):1557–1561
Sourisseau M, Schilte C, Casartelli N, Trouillet C, Guivel-Benhassine F, Rudnicka D et al (2007) Characterization of reemerging chikungunya virus. PLoS Pathog 3(6), e89. doi:10.1371/journal.ppat.0030089
Tait SW, Ichim G, Green DR (2014) Die another way—non-apoptotic mechanisms of cell death. J Cell Sci 127(Pt 10):2135–2144. doi:10.1242/jcs.093575
Taylor RC, Cullen SP, Martin SJ (2008) Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 9(3):231–241. doi:10.1038/nrm2312
Upton JW, Chan FK (2014) Staying alive: cell death in antiviral immunity. Mol Cell 54(2):273–280. doi:10.1016/j.molcel.2014.01.027
Wilson NS, Dixit V, Ashkenazi A (2009) Death receptor signal transducers: nodes of coordination in immune signaling networks. Nat Immunol 10(4):348–355. doi:10.1038/ni.1714
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Judith, D., Couderc, T., Lecuit, M. (2016). Chikungunya Virus-Induced Autophagy and Apoptosis. In: Okeoma, C. (eds) Chikungunya Virus. Springer, Cham. https://doi.org/10.1007/978-3-319-42958-8_9
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DOI: https://doi.org/10.1007/978-3-319-42958-8_9
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