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Central Neurocytoma

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Abstract

Central neurocytoma is a rare brain tumor usually in young adults, which arises most commonly in the supratentorial ventricular system. It frequently causes obstructive hydrocephalus and symptoms of increased intracranial pressure. Diagnosis is made based on characteristic pathologic findings consistent with neuronal differentiation including immunoreactivity with antibody to synaptophysin. Treatment paradigms include maximal safe surgical resection or definitive radiotherapy. After surgical resection, adjuvant radiotherapy may be indicated in the event of subtotal resection or if adverse pathologic features such as elevated MIB-1 labeling index are identified. In general, radiation therapy may be prescribed as conventionally fractionated radiotherapy to doses of 45–54 Gy at 1.8–2.0 Gy/fx for benign neurocytomas or 54–60 Gy in 2.0 Gy/fx for atypical neurocytomas. Stereotactic radiosurgery experiences have used mean marginal doses ranging from 10.5 to 20 Gy, though the majority were treated with mean marginal doses of 14–18 Gy in a single fraction. Local control is favorable with these therapies. After completion of radiotherapy, patients should be followed in the long term to evaluate for potential recurrences and radiation-induced late toxicities.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA

    Shireen Parsai & John H. Suh

  2. Department of Radiation Oncology, Illawarra Cancer Care Centre, Wollongong, NSW, Australia

    Senthilkumar Gandhidasan

Authors
  1. Shireen Parsai
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  2. Senthilkumar Gandhidasan
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  3. John H. Suh
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Corresponding author

Correspondence to John H. Suh .

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Keck School of Medicine of USC, Norris Cancer Hospital, Los Angeles, California, USA

    Eric L. Chang

  2. Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA

    Paul D. Brown

  3. Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA

    Simon S. Lo

  4. Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

    Arjun Sahgal

  5. Department of Radiation Oncology, Taussig Cancer Institute Cleveland Clinic, Cleveland, Ohio, USA

    John H. Suh

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Parsai, S., Gandhidasan, S., Suh, J.H. (2018). Central Neurocytoma. In: Chang, E., Brown, P., Lo, S., Sahgal, A., Suh, J. (eds) Adult CNS Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42878-9_29

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  • DOI: https://doi.org/10.1007/978-3-319-42878-9_29

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42877-2

  • Online ISBN: 978-3-319-42878-9

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