Abstract
Ependymomas are uncommon tumors arising from the ependymal cells lining the ventricles, central canal, filum terminale, or choroid plexus. As per WHO 2016 pathologic classification, ependymal tumors can be classified as grade I (subependymoma or myxopapillary), grade II [ependymoma (with papillary, clear cell, tanycytic subtypes)], or grade III (anaplastic). Clinical presentation depends on the tumor location. Prognostic factors include extent of resection, tumor grade, age at time of diagnosis, Karnofsky performance status (KPS), tumor location, and adjuvant radiation therapy, with arguably extent of resection being the most significant factor. Predominant pattern of recurrence is local. Management of adult intracranial ependymoma remains controversial, and multi-institutional prospective trials are needed.
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Suri, J.S., Youn, P., Milano, M.T. (2018). Intracranial Ependymoma. In: Chang, E., Brown, P., Lo, S., Sahgal, A., Suh, J. (eds) Adult CNS Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42878-9_28
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