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Meperidine: A Forgotten Jewel

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Abstract

Meperidine was the first opioid to be synthesized in the laboratory. Its use in anesthesia has declined in recent years for reasons unrelated to its clinical value. Examples of its use in surgical anesthesia are provided.

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References

  1. Eisleb O, Schaumann O. Dolantin, ein neuartiges spasmolytikum und analgetikum (chemisches und pharmakologisches). Dtsch Med Wschr. 1939;65:967–8.

    Article  CAS  Google Scholar 

  2. Schaumann O. Uber eine neue klasse von verbindungen mit spasmolytischer und zentral analgrtischer wirksamkeit unter besonderer berucksichtigung des 1-methyl-4phenyl-piperidin-4-carbonsaure-athylesters (dolantin). Archiv f Experiment Path u Pharmakol. 1940;196:109–36.

    Article  CAS  Google Scholar 

  3. Rovenstine EA, Batterman RC. The utility of Demerol as a substitute for the opiates in preanesthetic medication. Anesthesiology. 1943;4:126–34.

    Article  Google Scholar 

  4. Batterman RC, Himmelsbach CK. Demerol—a new synthetic analgesic. JAMA. 1943;122:222–6.

    Article  CAS  Google Scholar 

  5. Latta KS, Ginsberg B, Barkin RL. Meperidine: a critical review. Am J Ther. 2002;9:53–68.

    Article  PubMed  Google Scholar 

  6. Dobyns JB. Anesthesia for the patient with asthma. Curr Rev Clin Anesth. 2015;35:229–40.

    Google Scholar 

  7. Takada K, Clark DJ, Davies MF, Tonner PH, Krause TK, Bertaccini E, Maze M. Meperidine exerts agonist activity at the alpha (2B)-adrenoceptor subtype. Anesthesiology. 2002;96:1420–6.

    Article  CAS  PubMed  Google Scholar 

  8. Jaffe RA, Rowe MA. A comparison of the local anesthetic effects of meperidine, fentanyl, and sufentanil on dorsal root axons. Anesth Analg. 1996;83:776–81.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. David Geffen School of Medicine at UCLA, Los Angeles, California, USA

    C. Philip Larson Jr. MDCM (Professor Emeritus, Anesthesia and Neurosurgery Stanford University Professor of Clinical Anesthesiology (Ret.)

  2. Stanford University School of Medicine, Stanford, California, USA

    Richard A. Jaffe MD, PhD (Professor of Anesthesiology and Neurosurgery)

Authors
  1. C. Philip Larson Jr. MDCM
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  2. Richard A. Jaffe MD, PhD
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Larson, C.P., Jaffe, R.A. (2017). Meperidine: A Forgotten Jewel. In: Practical Anesthetic Management. Springer, Cham. https://doi.org/10.1007/978-3-319-42866-6_10

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  • DOI: https://doi.org/10.1007/978-3-319-42866-6_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42865-9

  • Online ISBN: 978-3-319-42866-6

  • eBook Packages: MedicineMedicine (R0)

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