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Fast and Furious 800. The Retinal Determination Gene Network in Drosophila

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Organogenetic Gene Networks

Abstract

The Drosophila compound eye is formed by about 800 ommatidia or simple eyes, packed in an almost crystalline lattice. The precise ommatidial arrangement makes the fly eye especially sensitive to pattern aberrations. These properties, together with the fact that the eye is an external and largely dispensable organ, have made the Drosophila eye an excellent genetic model to investigate the mechanisms of cell proliferation, patterning and differentiation, as well as mechanisms of human disease, such as cancer, neurodegeneration or metabolic pathologies. Part of these studies have coalesced into the Drosophila eye (or retinal) gene regulatory network (GRN): a text-book example of an organ-specification gene network that has been used as a point-of-comparison in the study of the mechanisms of eye specification and evolution, as well as a paradigm of signaling integration. This paper reviews the gene network that covers the period from eye progenitor specification to the onset of retinal differentiation as marked by activation of the proneural gene atonal, while paying special attention to the dynamics of the network and its intimate relation to the control of eye size.

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Notes

  1. 1.

    The origin of insect eyes from the cephalic neuroectoderm (Fernald 2000) resembles more the vertebrate sensory placodes (such as the lens, otic or olfactory placodes), which also derive from epithelial thickenings (Schlosser 2015), than the vertebrate retina, which forms as an evagination of the anterior neural tube. However, it is important to stress that the precursor cells for both the eye and the optic lobes of the brain originate from adjacent cell populations in the neuroectoderm. The difference being that the EAD invaginates as an epithelial sac, while the optic lobe neuroblasts internalize by delamination.

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Acknowledgments

Recent work in the Casares lab related to the subject of this review has been partly funded through grants BFU2009-07044 and BFU2012-34324 from the Spanish Ministry of Science and Innovation/MINECO. We specially thank S. Aerts (KU, Leuven), M. Friedrich (Wayne State Univ., Detroit), F. Pichaud (UCL, London) and F. Pignoni (Upstate Medical Univ., Syracuse) for their critical comments. IA has been supported through “Programa de Fortalecimiento” of Pablo de Olavide University and a MSC postdoctoral contract from the EU H2020 Program.

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  1. CABD (Andalusian Centre for Developmental Biology), CSIC-Pablo de Olavide University-Junta de Andalucía, Campus UPO, Ctra Utrera Km 1, 41013, Seville, Spain

    Fernando Casares & Isabel Almudi

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Correspondence to Fernando Casares .

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  1. CSIC/JA/UPO, Andalusian Centre for Developmental Biology (CABD), CSIC/JA/UPO, Seville, Spain

    James Castelli-Gair Hombría

  2. CSIC-UAM, Center for Molecular Biology Severo Ochoa and CIBERER, CSIC-UAM, Madrid, Spain

    Paola Bovolenta

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Casares, F., Almudi, I. (2016). Fast and Furious 800. The Retinal Determination Gene Network in Drosophila . In: Castelli-Gair Hombría, J., Bovolenta, P. (eds) Organogenetic Gene Networks. Springer, Cham. https://doi.org/10.1007/978-3-319-42767-6_4

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