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Organogenesis of the C. elegans Vulva and Control of Cell Fusion

Chapter

Abstract

The vulva of Caenorhabditis elegans is widely used as a paradigm for the study of organogenesis and is composed of seven toroids, formed by the migration of cells and the formation of homotypic contacts. Five of the toroids contain two or four nuclei and cell membrane fusion is one of the main driving forces during the morphogenesis of the vulva. The network of genes involved in the control of cell fusion during the formation of the vulva must determine which cells fuse and when. Especially during the formation of the vulval toroids, when those cells that fuse to form each ring, must not fuse with the neighbor cells, which form other separate rings. This is achieved through very fine control on the expression and function of several key genes.

Keywords

Vulva morphogenesis Caenorhabditis elegans Cell fusion Organogenesis Signaling pathways eff-1 aff-1 Wnt Notch RTK-Ras-ERK Vulval toroids Developmental genetics Cell differentiation Cell invasion Anchor cell Vulval precursors Fate determination Cell migration Cell lineage Cell polarization Transcriptional control Modeling Uterine-vulval connection Nematodes Evolution Evo-devo 

Notes

Acknowledgments

We thank Alex Hajnal and Gidi Shemer for critically reading the manuscript. BP was a Grass fellow at Radcliffe Institute for Advanced Study at Harvard University. The work in BP lab was funded by European Research Council (ERC) Advanced grant 268843, GIF German-Israeli Foundation for Scientific Research and Development (grant 937/2006), US-Israel Binational Science Foundation grant 2013151 and the Israel Science Foundation grant 443/12. The work of NW was partially supported by ABACUS, CONACyT grant EDOMEX-2011-C01-165873.

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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.ABACUS-Centro de Matemáticas Aplicadas y Cómputo de Alto Rendimiento, Departamento de Matemáticas, Centro de Investigación y de Estudios Avanzados CINVESTAV-IPNLa Marquesa, OcoyoacacMexico
  2. 2.Department of BiologyTechnion—Israel Institute of TechnologyHaifaIsrael

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