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The Thalamostriatal System and Cognition

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The Basal Ganglia

Part of the book series: Innovations in Cognitive Neuroscience ((Innovations Cogn.Neuroscience))

Abstract

The basal ganglia play a critical role in a wide range of cognitive functions. Consequently, neurodegenerative diseases that affect the basal ganglia, such as Parkinson’s disease (PD) and Huntington’s disease (HD), are commonly associated with cognitive impairments. Although dysfunction of the relationships between the prefrontal cortex and the caudate nucleus is likely to be involved in these deficits, data collected over the past decade strongly suggest that the thalamostriatal system from the centromedian (CM) and parafascicular (PF) nuclei is another important regulator of cognitive functions in the basal ganglia. The fact that the CM/PF undergoes severe degeneration in HD and PD further supports the possible contribution of the thalamostriatal system pathology to cognitive dysfunctions in these disorders.

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Acknowledgments

This work was supported by grants from the National Institutes of Health to YS and TW (R01 NS083386; P50NS071669) and the NIH infrastructure grant to the Yerkes National Primate Research Center (P51 OD011132).

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Authors and Affiliations

  1. Department of Neurology, Yerkes National Primate Research Center, Emory University, 954, Gatewood Rd NE, Atlanta, GA, 30329, USA

    Yoland Smith Ph.D., Rosa Villalba Ph.D. & Adriana Galvan Ph.D.

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  1. Yoland Smith Ph.D.
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  2. Rosa Villalba Ph.D.
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  3. Adriana Galvan Ph.D.
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Correspondence to Yoland Smith Ph.D. .

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Editors and Affiliations

  1. Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, USA

    Jean-Jacques Soghomonian

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Smith, Y., Villalba, R., Galvan, A. (2016). The Thalamostriatal System and Cognition. In: Soghomonian, JJ. (eds) The Basal Ganglia. Innovations in Cognitive Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-42743-0_4

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