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Anatomy and Function of the Direct and Indirect Striatal Pathways

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The Basal Ganglia

Part of the book series: Innovations in Cognitive Neuroscience ((Innovations Cogn.Neuroscience))

Abstract

The striatum is known as the input structure of the basal ganglia because it integrates prominent inputs from several regions of the cerebral cortex and the hippocampus and controls neuronal activities in the SNr and Gpi/entopeduncular nucleus, whose neurons project outside the basal ganglia to motor and premotor brain regions. The striatum exerts its actions on the basal ganglia output via two pathways known as the direct and indirect pathway. These two pathways are central to our current understanding of the functional organization of the basal ganglia. This chapter describes the experimental basis for the distinction between a direct and indirect pathway and the hypothesized functional roles of these two pathways.

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  1. Department of Anatomy and Neurobiology, Boston University School of Medicine, 72 E. Concord Street, Boston, MA, 02118, USA

    Jean-Jacques Soghomonian Ph.D.

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    Jean-Jacques Soghomonian

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Soghomonian, JJ. (2016). Anatomy and Function of the Direct and Indirect Striatal Pathways. In: Soghomonian, JJ. (eds) The Basal Ganglia. Innovations in Cognitive Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-42743-0_3

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