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Targeting Autophagy in Cancer Therapy pp 59–84Cite as

Regulation of Autophagy by microRNAs: Implications in Cancer Therapy

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Part of the book series: Current Cancer Research ((CUCR))

Abstract

As an emerging hallmark of cancer, aberrant energy metabolism has drawn increasing attention in both basic research and clinical study. Autophagy is one of the main mechanisms for cells to maintain metabolic homeostasis, and cancer cells often display altered autophagic activity. Thus, autophagy is now pursued as a target for anti-cancer therapies. The current approaches to modulating autophagy include manipulation of either expressions or functions of the proteins that are key components of autophagic pathways. As a main post-transcriptional regulatory factor, microRNAs play important roles in various physiological and pathophysiological processes including cancers. Since miR-30a was first reported to regulate autophagy through targeting 3′ untranslated region (3′ UTR) of Beclin-1, a key autophagy regulatory gene, numerous miRNAs involved in autophagy regulation have been reported. Here we overview the current knowledge regarding the roles of miRNAs in regulation of autophagy and their implication in cancer therapy.

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  1. Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W 12th Avenue, Columbus, OH, 43210, USA

    Hua Zhu

  2. Department of Pharmacology, The Penn State Hershey Cancer Institute, The Pennsylvania State University, College of Medicine and Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA

    Jin-Ming Yang

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    Jin-Ming Yang

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Zhu, H., Yang, JM. (2016). Regulation of Autophagy by microRNAs: Implications in Cancer Therapy. In: Yang, JM. (eds) Targeting Autophagy in Cancer Therapy. Current Cancer Research. Springer, Cham. https://doi.org/10.1007/978-3-319-42740-9_4

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