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Formulating Poorly Water Soluble Drugs pp 437–525Cite as

Spray-Drying Technology

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Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 22))

Abstract

This chapter provides an in-depth review of spray-drying technology and its application to the formulation of poorly water-soluble drugs. In the early part of the chapter, the fundamentals of the process are discussed, including process theory, process components, equipment options, equipment by scale, various feeds, and typical solvent systems. In the latter part of the chapter, the application of spray drying to the formulation of poorly water-soluble drugs is discussed. Particular emphasis is given to spray drying for amorphous solid dispersion systems. The path toward developing an amorphous spray-dried dispersion and conversion to a final dosage form is covered in detail. Additionally, several academic and industrial examples are presented, illustrating the benefits of the process as a formulation technology and its commercial viability. Finally, the application of spray drying, inhalation, and emerging applications—i.e., spray congealing and micro-encapsulation are reviewed. This chapter provides comprehensive coverage of the spray-drying process and its uses as a formulation technology toward the enhancement of drug delivery with poorly water-soluble compounds.

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Authors and Affiliations

  1. DisperSol Technologies, LLC, 111 W Cooperative Way, Building 3, Georgetown, TX, 78626, USA

    Dave A. Miller & Daniel Ellenberger

  2. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, 2409 West University Avenue, PHR 4.214, Austin, TX, 78712, USA

    Daniel Ellenberger

  3. Hovione LLC, 21204 Cedar St, Lawrenceville, NJ, 08648, USA

    Marco Gil

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  1. Dave A. Miller
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  2. Daniel Ellenberger
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  3. Marco Gil
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Correspondence to Dave A. Miller .

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Editors and Affiliations

  1. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA

    Robert O. Williams III

  2. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA

    Alan B. Watts

  3. DisperSol Technologies, LLC, Georgetown, Texas, USA

    Dave A. Miller

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Miller, D.A., Ellenberger, D., Gil, M. (2016). Spray-Drying Technology. In: Williams III, R., Watts, A., Miller, D. (eds) Formulating Poorly Water Soluble Drugs. AAPS Advances in the Pharmaceutical Sciences Series, vol 22. Springer, Cham. https://doi.org/10.1007/978-3-319-42609-9_10

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