Abstract
Genetically engineered recombinant allergens have the ability to improve allergy diagnosis and are used as reference standards for analytical methods. In addition, the use of recombinant allergens in allergen-specific immunotherapy has long been considered potentially superior compared with the use of conventional extracts. The advantages are clear: A complex natural substance that is difficult to characterize is replaced by only those components relevant for treatment, which can be reproduced in very high quality. The challenges faced here include selecting the necessary allergen molecules and establishing a production method that meets all the regulatory requirements of marketing authorization. In addition to unmodified recombinant allergens, hypoallergenic variants with lower IgE reactivity can also be produced using genetic engineering techniques; proof of concept has been demonstrated for both these concepts in clinical trials.
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The present chapter is based on, and modified from, an article by the authors published in 2015 in Allergo Journal International (Nandy A, Häfner D, Klysner S: Recombinant allergens for specific immunotherapy: Current concepts and developments. Allergo J Int 2015; 24:143–151).
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Nandy, A., Creticos, P.S., Häfner, D. (2017). Recombinant Allergens in Specific Immunotherapy. In: Kleine-Tebbe, J., Jakob, T. (eds) Molecular Allergy Diagnostics. Springer, Cham. https://doi.org/10.1007/978-3-319-42499-6_26
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DOI: https://doi.org/10.1007/978-3-319-42499-6_26
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