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Extract-Based and Molecular Diagnostics in Fish Allergy

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Molecular Allergy Diagnostics

Abstract

Although fish is an elementary component of a healthy diet, it is also a food with high allergenic potential. In most cases, allergic reactions are induced by parvalbumins – small, stable proteins found in the muscle tissue. Many parvalbumin-positive individuals present with clinical reactions to various fish species, which can be explained through cross-reacting IgE antibodies.

Thus far, complete fish extracts and two recombinant parvalbumins are available for IgE-based routine diagnostic procedures. Other important fish allergens are the enolases, the aldolases, and tropomyosin derived from fish muscle and vitellogenin from fish eggs, whose availability for diagnostics would allow more precise analysis of the sensitization profile of a fish-allergic patient. To date, there is no specific immunotherapy for fish allergy available. However, molecular biotechnological approaches have already led to the development of the first hypoallergenic molecules, which offer low-risk therapeutic prospects for the future.

This contribution is based on a publication by the authors that appeared in the Allergo Journal in 2012 (Kuehn A, Radauer C, Swoboda I, Kleine-Tebbe J: Fischallergie – Parvalbumine und andere Allergene. Allergo J. 2012;21:16–18) and which has now been updated, expanded, and translated into English as a chapter for this book.

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Authors and Affiliations

  1. Allergology – Immunology – Inflammation Research Unit, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg

    A. Kuehn PhD

  2. Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria

    C. Radauer PhD, Prof.

  3. Molecular Allergy Research Laboratory, Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia

    A. L. Lopata PhD, Prof.

  4. Allergy and Asthma Center Westend, Outpatient Clinic Hanf, Ackermann and Kleine-Tebbe, Berlin, Germany

    J. Kleine-Tebbe MD, Prof.

  5. Molecular Biotechnology Section, FH Campus Wien, University of Applied Sciences, Vienna, Austria

    I. Swoboda PhD, Prof.

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  1. A. Kuehn PhD
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  2. C. Radauer PhD, Prof.
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  3. A. L. Lopata PhD, Prof.
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  4. J. Kleine-Tebbe MD, Prof.
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  5. I. Swoboda PhD, Prof.
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Correspondence to A. Kuehn PhD .

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Editors and Affiliations

  1. Professor of Dermatology and Allergology, Allergy and Asthma Center Westend Outpatient Clinic Hanf, Ackermann and Kleine-Tebbe, Berlin, Germany

    Jörg Kleine-Tebbe

  2. Professor of Dermatology and Allergology Chairman of the Department of Dermatology and Allergology, University Medical Center Gießen and Marburg Campus Gießen Justus Liebig University Gießen, Gießen, Germany

    Thilo Jakob

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Kuehn, A., Radauer, C., Lopata, A.L., Kleine-Tebbe, J., Swoboda, I. (2017). Extract-Based and Molecular Diagnostics in Fish Allergy. In: Kleine-Tebbe, J., Jakob, T. (eds) Molecular Allergy Diagnostics. Springer, Cham. https://doi.org/10.1007/978-3-319-42499-6_20

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  • DOI: https://doi.org/10.1007/978-3-319-42499-6_20

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