Skip to main content
SpringerLink
Log in

Molecular Diagnostics of Allergy to Fruits and Vegetables

  • Chapter
  • First Online:
Molecular Allergy Diagnostics

Abstract

No Pan-European studies on the prevalence of food allergy have yet been reported. Previously published findings, generally from regional evaluations, have shown that allergies to fruits and vegetables are among the most common food allergies in adolescence and adulthood. This chapter on molecular diagnostics of fruit and vegetable allergy summarizes data from component-resolved diagnostic studies on individuals with confirmed food allergy. The main focus is on the most frequent allergies to fruits and vegetables, such as to carrot, celery root, tomato, kiwi fruit, and peach, an important representative from the Rosaceae fruits. Research demonstrates that component-resolved diagnostics can make an important contribution to improving in vitro diagnostics in food allergy. Identification of marker allergens associated with an increased risk of developing severe systemic reactions will aid in the future management of food-allergic patients.

This contribution is based on a publication by the authors that appeared in the Allergo Journal International in 2014 (Ballmer-Weber BK, Hoffmann-Sommergruber K: Update: molecular diagnostics of allergies to vegetables and fruits. Allergo J Int 2014; 23: 24–34), which has been updated and expanded as a chapter for this book.

The authors gratefully thank Jan B. Bernhisel-Broadbent, MD (Granger Asthma & Allergy, Murray, UT); Kate Broadbent, PhD, Salt Lake City, UT; and Kenneth R. Broadbent, MD (Wasatch Pediatrics at St. Marks) Salt Lake City, UT, USA, for carefully reviewing the manuscript, helpful suggestions, and editorial assistance with the English translation

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aleman A, Sastre J, Quirce S, de las Heras M, Carnes J, Fernandez-Caldas E, Pastor C, Blazquez AB, Vivanco F, Cuesta-Herranz J. Allergy to kiwi: a double-blind, placebo-controlled food challenge study in patients from a birch-free area. J Allergy Clin Immunol. 2004;113:543–50.

    Article  CAS  PubMed  Google Scholar 

  • Asero R, Antonicelli L, Arena A, Bommarito L, Caruso B, Crivellaro M, De Carli M, Della Torre E, Della Torre F, Heffler E, Lodi Rizzini F, Longo R, Manzotti G, Marcotulli M, Melchiorre A, Minale P, Morandi P, Moreni B, Moschella A, Murzilli F, Nebiolo F, Poppa M, Randazzo S, Rossi G, Senna GE. EpidemAAITO: features of food allergy in Italian adults attending allergy clinics: a multi-centre study. Clin Exp Allergy. 2009;39:547–55.

    Article  CAS  PubMed  Google Scholar 

  • Ballmer-Weber BK, Vieths S, Luttkopf D, Heuschmann P, Wuthrich B. Celery allergy confirmed by double-blind, placebo-controlled food challenge: a clinical study in 32 subjects with a history of adverse reactions to celery root. J Allergy Clin Immunol. 2000;106:373–8.

    Article  CAS  PubMed  Google Scholar 

  • Ballmer-Weber BK, Wuthrich B, Wangorsch A, Fotisch K, Altmann F, Vieths S. Carrot allergy: double-blinded, placebo-controlled food challenge and identification of allergens. J Allergy Clin Immunol. 2001;108:301–7.

    Article  CAS  PubMed  Google Scholar 

  • Ballmer-Weber BK, Wangorsch A, Bohle B, Kaul S, Kundig T, Fotisch K, van Ree R, Vieths S. Component-resolved in vitro diagnosis in carrot allergy: does the use of recombinant carrot allergens improve the reliability of the diagnostic procedure? Clin Exp Allergy. 2005;35:970–8.

    Article  CAS  PubMed  Google Scholar 

  • Ballmer-Weber BK, Hoffmann-Sommergruber K. Molecular diagnosis of fruit and vegetable allergy. Curr Opin Allergy Clin Immunol. 2011;11:229–35.

    Article  CAS  PubMed  Google Scholar 

  • Ballmer-Weber BK, Skamstrup Hansen K, Sastre J, Andersson K, Batscher I, Ostling J, Dahl L, Hanschmann KM, Holzhauser T, Poulsen LK, Lidholm J, Vieths S. Component-resolved in vitro diagnosis of carrot allergy in three different regions of Europe. Allergy. 2012;67:758–66.

    Article  CAS  PubMed  Google Scholar 

  • Bassler OY, Weiss J, Wienkoop S, Lehmann K, Scheler C, Dolle S, Schwarz D, Franken P, George E, Worm M, Weckwerth W. Evidence for novel tomato seed allergens: IgE-reactive legumin and vicilin proteins identified by multidimensional protein fractionation-mass spectrometry and in silico epitope modeling. J Proteome Res. 2009;8:1111–22.

    Article  PubMed  Google Scholar 

  • Bauermeister K, Ballmer-Weber BK, Bublin M, Fritsche P, Hanschmann KM, Hoffmann-Sommergruber K, Lidholm J, Oberhuber C, Randow S, Holzhauser T, Vieths S. Assessment of component-resolved in vitro diagnosis of celeriac allergy. J Allergy Clin Immunol. 2009;124:1273–81.

    Article  CAS  PubMed  Google Scholar 

  • Bernardi ML, Giangrieco I, Camardella L, Ferrara R, Palazzo P, Panico MR, Crescenzo R, Carratore V, Zennaro D, Liso M, Santoro M, Zuzzi S, Tamburrini M, Ciardiello MA, Mari A. Allergenic lipid transfer proteins from plant-derived foods do not immunologically and clinically behave homogeneously: the kiwifruit LTP as a model. PLoS One. 2011;6:e27856.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brehler R, Theissen U, Mohr C, Luger T. “Latex-fruit syndrome”: frequency of cross-reacting IgE antibodies. Allergy. 1997;52:404–10.

    Article  CAS  PubMed  Google Scholar 

  • Bublin M, Radauer C, Wilson IB, Kraft D, Scheiner O, Breiteneder H, Hoffmann-Sommergruber K. Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patients. FASEB J. 2003;17:1697–9.

    CAS  PubMed  Google Scholar 

  • Bublin M, Mari A, Ebner C, Knulst A, Scheiner O, Hoffmann-Sommergruber K, Breiteneder H, Radauer C. IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries. J Allergy Clin Immunol. 2004;114:1169–75.

    Article  CAS  PubMed  Google Scholar 

  • Bublin M, Pfister M, Radauer C, Oberhuber C, Bulley S, Dewitt AM, Lidholm J, Reese G, Vieths S, Breiteneder H, Hoffmann-Sommergruber K, Ballmer-Weber BK. Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens. J Allergy Clin Immunol. 2010;125:687–94.

    Google Scholar 

  • Bublin M, Dennstedt S, Buchegger M, Antonietta Ciardiello M, Bernardi ML, Tuppo L, Harwanegg C, Hafner C, Ebner C, Ballmer-Weber BK, Knulst A, Hoffmann-Sommergruber K, Radauer C, Mari A, Breiteneder H. The performance of a component-based allergen microarray for the diagnosis of kiwifruit allergy. Clin Exp Allergy. 2011;41:129–36.

    Google Scholar 

  • Burney P, Summers C, Chinn S, Hooper R, van Ree R, Lidholm J. Prevalence and distribution of sensitization to foods in the European Community Respiratory Health Survey: a EuroPrevall analysis. Allergy. 2010;65:1182–8.

    CAS  PubMed  Google Scholar 

  • Burney PG, Potts J, Kummeling I, Mills EN, Clausen M, Dubakiene R, Barreales L, Fernandez-Perez C, Fernandez-Rivas M, Le TM, Knulst AC, Kowalski ML, Lidholm J, Ballmer-Weber BK, Braun-Fahlander C, Mustakov T, Kralimarkova T, Popov T, Sakellariou A, Papadopoulos NG, Versteeg SA, Zuidmeer L, Akkerdaas JH, Hoffmann-Sommergruber K, van Ree R. The prevalence and distribution of food sensitization in European adults. Allergy. 2014;69:365–71.

    Article  CAS  PubMed  Google Scholar 

  • Caimmi D, Barber D, Hoffmann-Sommergruber K, Amrane H, Bousquet PJ, Dhivert-Donnadieu H, Demoly P. Understanding the molecular sensitization for Cypress pollen and peach in the Languedoc-Roussillon area. Allergy. 2013;68:249–51.

    Article  CAS  PubMed  Google Scholar 

  • Ciardiello MA, D’Avino R, Amoresano A, Tuppo L, Carpentieri A, Carratore V, Tamburrini M, Giovane A, Pucci P, Camardella L. The peculiar structural features of kiwi fruit pectin methylesterase: amino acid sequence, oligosaccharides structure, and modeling of the interaction with its natural proteinaceous inhibitor. Proteins. 2008;71:195–206.

    Article  CAS  PubMed  Google Scholar 

  • Cuesta-Herranz J, Barber D, Blanco C, Cistero-Bahima A, Crespo JF, Fernandez-Rivas M, Fernandez-Sanchez J, Florido JF, Ibanez MD, Rodriguez R, Salcedo G, Garcia BE, Lombardero M, Quiralte J, Rodriguez J, Sanchez-Monge R, Vereda A, Villalba M, Alonso Diaz de Durana MD, Basagana M, Carrillo T, Fernandez-Nieto M, Tabar AI. Differences among pollen-allergic patients with and without plant food allergy. Int Arch Allergy Immunol. 2010;153:182–92.

    Article  CAS  PubMed  Google Scholar 

  • D’Avino R, Bernardi ML, Wallner M, Palazzo P, Camardella L, Tuppo L, Alessandri C, Breiteneder H, Ferreira F, Ciardiello MA, Mari A. Kiwifruit Act d 11 is the first member of the ripening-related protein family identified as an allergen. Allergy. 2011;66:870–7.

    Article  PubMed  Google Scholar 

  • Eriksson N, Werner S, Foucard T, Möller C, Berg T, Kiviloog J. Self-reportend hypersensitivity to exotic fruit in brich pollen-allergic patients. Allergol Int. 2003;52:199–206.

    Article  Google Scholar 

  • Fernandez-Rivas M, Gonzalez-Mancebo E, Rodriguez-Perez R, Benito C, Sanchez-Monge R, Salcedo G, Alonso MD, Rosado A, Tejedor MA, Vila C, Casas ML. Clinically relevant peach allergy is related to peach lipid transfer protein, Pru p 3, in the Spanish population. J Allergy Clin Immunol. 2003;112:789–95.

    Article  CAS  PubMed  Google Scholar 

  • Fernandez-Rivas M, Bolhaar S, Gonzalez-Mancebo E, Asero R, van Leeuwen A, Bohle B, Ma Y, Ebner C, Rigby N, Sancho AI, Miles S, Zuidmeer L, Knulst A, Breiteneder H, Mills C, Hoffmann-Sommergruber K, van Ree R. Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. J Allergy Clin Immunol. 2006;118:481–8.

    Article  CAS  PubMed  Google Scholar 

  • Foetisch K, Son DY, Altmann F, Aulepp H, Conti A, Haustein D, Vieths S. Tomato (Lycopersicon esculentum) allergens in pollen-allergic patients. Eur Food Res Technol. 2001;213:259–66.

    Article  CAS  Google Scholar 

  • Fujita C, Moriyama T, Ogawa T. Identification of cyclophilin as an IgE-binding protein from carrots. Int Arch Allergy Immunol. 2001;125:44–50.

    Article  CAS  PubMed  Google Scholar 

  • Gadermaier G, Hauser M, Egger M, Ferrara R, Briza P, Santos KS, Zennaro D, Girbl T, Zuidmeer-Jongejan L, Mari A, Ferreira F. Sensitization prevalence, antibody cross-reactivity and immunogenic peptide profile of Api g 2, the non-specific lipid transfer protein 1 of celery. PLoS One. 2011;6:e24150.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gaier S, Marsh J, Oberhuber C, Rigby NM, Lovegrove A, Alessandri S, Briza P, Radauer C, Zuidmeer L, van Ree R, Hemmer W, Sancho AI, Mills C, Hoffmann-Sommergruber K, Shewry PR. Purification and structural stability of the peach allergens Pru p 1 and Pru p 3. Mol Nutr Food Res. 2008;52 Suppl 2:S220–9.

    PubMed  Google Scholar 

  • Gall H, Kalveram KJ, Forck G, Sterry W. Kiwi fruit allergy: a new birch pollen-associated food allergy. J Allergy Clin Immunol. 1994;94:70–6.

    Article  CAS  PubMed  Google Scholar 

  • Gao ZS, Yang ZW, Wu SD, Wang HY, Liu ML, Mao WL, Wang J, Gadermaier G, Ferreira F, Zheng M, van Ree R. Peach allergy in China: a dominant role for mugwort pollen lipid transfer protein as a primary sensitizer. J Allergy Clin Immunol. 2013;131(224–226):e221–3.

    Google Scholar 

  • Gavrovic-Jankulovic M, cIrkovic T, Vuckovic O, Atanaskovic-Markovic M, Petersen A, Gojgic G, Burazer L, Jankov RM. Isolation and biochemical characterization of a thaumatin-like kiwi allergen. J Allergy Clin Immunol. 2002;110:805–10.

    Article  CAS  PubMed  Google Scholar 

  • Giangrieco I, Alessandri C, Rafaiani C, Santoro M, Zuzzi S, Tuppo L, Tamburrini M, D’Avino R, Ciardiello MA, Mari A. Structural features, IgE binding and preliminary clinical findings of the 7 kDa lipid transfer protein from tomato seeds. Mol Immunol. 2015;66:154–63.

    Google Scholar 

  • Gonzalez-Mancebo E, Fernandez-Rivas M. Outcome and safety of double-blind, placebo-controlled food challenges in 111 patients sensitized to lipid transfer proteins. J Allergy Clin Immunol. 2008;121:1507–8.

    Article  CAS  PubMed  Google Scholar 

  • Grozdanovic M, Popovic M, Polovic N, Burazer L, Vuckovic O, Atanaskovic-Markovic M, Lindner B, Petersen A, Gavrovic-Jankulovic M. Evaluation of IgE reactivity of active and thermally inactivated actinidin, a biomarker of kiwifruit allergy. Food Chem Toxicol. 2012;50:1013–8.

    Article  CAS  PubMed  Google Scholar 

  • Hoffmann-Sommergruber K, O’Riordain G, Ahorn H, Ebner C, Laimer Da Camara Machado M, Puhringer H, Scheiner O, Breiteneder H. Molecular characterization of Dau c 1, the Bet v 1 homologous protein from carrot and its cross-reactivity with Bet v 1 and Api g 1. Clin Exp Allergy. 1999;29:840–7.

    Article  CAS  PubMed  Google Scholar 

  • Hoffmann-Sommergruber K, Ferris R, Pec M, Radauer C, O’Riordain G, Laimer Da Camara Machado M, Scheiner O, Breiteneder H. Characterization of Api g 1.0201, a new member of the Api g 1 family of celery allergens. Int Arch Allergy Immunol. 2000;122:115–23.

    Article  CAS  PubMed  Google Scholar 

  • Inschlag C, Hoffmann-Sommergruber K, O’Riordain G, Ahorn H, Ebner C, Scheiner O, Breiteneder H. Biochemical characterization of Pru a 2, a 23-kD thaumatin-like protein representing a potential major allergen in cherry (Prunus avium). Int Arch Allergy Immunol. 1998;116:22–8.

    Article  CAS  PubMed  Google Scholar 

  • Jenkins JA, Griffiths-Jones S, Shewry PR, Breiteneder H, Mills EN. Structural relatedness of plant food allergens with specific reference to cross-reactive allergens: an in silico analysis. J Allergy Clin Immunol. 2005;115:163–70.

    Article  CAS  PubMed  Google Scholar 

  • Jensen-Jarolim E, Santner B, Leitner A, Grimm R, Scheiner O, Ebner C, Breiteneder H. Bell peppers (Capsicum annuum) express allergens (profilin, pathogenesis-related protein P23 and Bet v 1) depending on the horticultural strain. Int Arch Allergy Immunol. 1998;116:103–9.

    Article  CAS  PubMed  Google Scholar 

  • Karamloo F, Wangorsch A, Kasahara H, Davin LB, Haustein D, Lewis NG, Vieths S. Phenylcoumaran benzylic ether and isoflavonoid reductases are a new class of cross-reactive allergens in birch pollen, fruits and vegetables. Eur J Biochem. 2001;268:5310–20.

    Article  CAS  PubMed  Google Scholar 

  • Kummeling I, Mills EN, Clausen M, Dubakiene R, Perez CF, Fernandez-Rivas M, Knulst AC, Kowalski ML, Lidholm J, Le TM, Metzler C, Mustakov T, Popov T, Potts J, van Ree R, Sakellariou A, Tondury B, Tzannis K, Burney P. The EuroPrevall surveys on the prevalence of food allergies in children and adults: background and study methodology. Allergy. 2009;64:1493–7.

    Article  CAS  PubMed  Google Scholar 

  • Larramendi CH, Ferrer A, Huertas AJ, Garcia-Abujeta JL, Andreu C, Tella R, Cerda MT, Bartra J, Lavin JR, Pagan JA, Lopez-Matas MA, Fernandez-Caldas E, Carnes J. Sensitization to tomato peel and pulp extracts in the Mediterranean Coast of Spain: prevalence and co-sensitization with aeroallergens. Clin Exp Allergy. 2008;38:169–77.

    CAS  PubMed  Google Scholar 

  • Le LQ, Mahler V, Scheurer S, Foetisch K, Braun Y, Weigand D, Enrique E, Lidholm J, Paulus KE, Sonnewald S, Vieths S, Sonnewald U. Yeast profilin complements profilin deficiency in transgenic tomato fruits and allows development of hypoallergenic tomato fruits. FASEB J. 2010;24:4939–47.

    Article  CAS  PubMed  Google Scholar 

  • Le TM, Fritsche P, Bublin M, Oberhuber C, Bulley S, van Hoffen E, Ballmer-Weber BK, Knulst AC, Hoffmann-Sommergruber K. Differences in the allergenicity of 6 different kiwifruit cultivars analyzed by prick-to-prick testing, open food challenges, and ELISA. J Allergy Clin Immunol. 2011;127:677–9.

    Google Scholar 

  • Lidholm J, Ballmer-Weber BK, Mari A, Vieths S. Component-resolved diagnostics in food allergy. Curr Opin Allergy Clin Immunol. 2006;6:234–40.

    Article  CAS  PubMed  Google Scholar 

  • Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Biló MB, Blank S, Bohle B, Bosshard PP, Breiteneder H, Brough HA, Caraballo L, Caubet JC, Crameri R, Davies JM, Douladiris N, Ebisawa M, Eigenmann PA, Fernandez-Rivas M, Ferreira F, Gadermaier G, Glatz M, Hamilton RG, Hawranek T, Hellings P, Hoffmann-Sommergruber K, Jakob T, Jappe U, Jutel M, Kamath SD, Knol EF, Korosec P, Kuehn A, Lack G, Lopata AL, Mäkelä M, Morisset M, Niederberger V, Nowak-Wezgrzyn AH, Papadopoulos NG, Pastorello EA, Pauli G, Platts-Mills T, Posa D, Poulsen LK, Raulf M, Sastre J, Scala E, Schmid JM, Schmid-Grendelmeier P, van Hage M, van Ree R, Vieths S, Weber R, Wickman M, Muraro A, Ollert M. EAACI molecular allergology user’s guide. Pediatr Allergy Immunol. 2016;27 Suppl 23:1–250.

    Article  PubMed  Google Scholar 

  • Mattila L, Kilpelainen M, Terho EO, Koskenvuo M, Helenius H, Kalimo K. Food hypersensitivity among Finnish university students: association with atopic diseases. Clin Exp Allergy. 2003;33:600–6.

    Article  CAS  PubMed  Google Scholar 

  • Oberhuber C, Bulley SM, Ballmer-Weber BK, Bublin M, Gaier S, DeWitt AM, Briza P, Hofstetter G, Lidholm J, Vieths S, Hoffmann-Sommergruber K. Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy. Mol Nutr Food Res. 2008;52 Suppl 2:S230–40.

    PubMed  Google Scholar 

  • Palacin A, Rodriguez J, Blanco C, Lopez-Torrejon G, Sanchez-Monge R, Varela J, Jimenez MA, Cumplido J, Carrillo T, Crespo JF, Salcedo G. Immunoglobulin E recognition patterns to purified Kiwifruit (Actinidinia deliciosa) allergens in patients sensitized to Kiwi with different clinical symptoms. Clin Exp Allergy. 2008;38:1220–8.

    Article  CAS  PubMed  Google Scholar 

  • Palacin A, Tordesillas L, Gamboa P, Sanchez-Monge R, Cuesta-Herranz J, Sanz ML, Barber D, Salcedo G, Diaz-Perales A. Characterization of peach thaumatin-like proteins and their identification as major peach allergens. Clin Exp Allergy. 2010;40:1422–30.

    Article  CAS  PubMed  Google Scholar 

  • Palacin A, Rivas LA, Gomez-Casado C, Aguirre J, Tordesillas L, Bartra J, Blanco C, Carrillo T, Cuesta-Herranz J, Bonny JA, Flores E, Garcia-Alvarez-Eire MG, Garcia-Nunez I, Fernandez FJ, Gamboa P, Munoz R, Sanchez-Monge R, Torres M, Losada SV, Villalba M, Vega F, Parro V, Blanca M, Salcedo G, Diaz-Perales A. The involvement of thaumatin-like proteins in plant food cross-reactivity: a multicenter study using a specific protein microarray. PLoS One. 2012;7:e44088.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pascal M, Munoz-Cano R, Reina Z, Palacin A, Vilella R, Picado C, Juan M, Sanchez-Lopez J, Rueda M, Salcedo G, Valero A, Yague J, Bartra J. Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens. Clin Exp Allergy. 2012;42:1529–39.

    Article  CAS  PubMed  Google Scholar 

  • Pastorello EA, Conti A, Pravettoni V, Farioli L, Rivolta F, Ansaloni R, Ispano M, Incorvaia C, Giuffrida MG, Ortolani C. Identification of actinidin as the major allergen of kiwi fruit. J Allergy Clin Immunol. 1998;101:531–7.

    Google Scholar 

  • Pravettoni V, Primavesi L, Farioli L, Brenna OV, Pompei C, Conti A, Scibilia J, Piantanida M, Mascheri A, Pastorello EA. Tomato allergy: detection of IgE-binding lipid transfer proteins in tomato derivatives and in fresh tomato peel, pulp, and seeds. J Agric Food Chem. 2009;57:10749–54.

    Article  CAS  PubMed  Google Scholar 

  • Radauer C, Adhami F, Furtler I, Wagner S, Allwardt D, Scala E, Ebner C, Hafner C, Hemmer W, Mari A, Breiteneder H. Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergy. Mol Immunol. 2011;48:600–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Radauer C, Nandy A, Ferreira F, Goodman RE, Larsen JN, Lidholm J, Pomes A, Raulf-Heimsoth M, Rozynek P, Thomas WR, Breiteneder H. Update of the WHO/IUIS Allergen Nomenclature Database based on analysis of allergen sequences. Allergy. 2014;69:413–9.

    Article  CAS  PubMed  Google Scholar 

  • Rance F, Grandmottet X, Grandjean H. Prevalence and main characteristics of schoolchildren diagnosed with food allergies in France. Clin Exp Allergy. 2005;35:167–72.

    Article  CAS  PubMed  Google Scholar 

  • Rodriguez-Perez R, Fernandez-Rivas M, Gonzalez-Mancebo E, Sanchez-Monge R, Diaz-Perales A, Salcedo G. Peach profilin: cloning, heterologous expression and cross-reactivity with Bet v 2. Allergy. 2003;58:635–40.

    Article  CAS  PubMed  Google Scholar 

  • Sanchez-Lopez J, Asturias JA, Enrique E, Suarez-Cervera M, Bartra J. Cupressus arizonica pollen: a new pollen involved in the lipid transfer protein syndrome? J Investig Allergol Clin Immunol. 2011;21:522–6.

    CAS  PubMed  Google Scholar 

  • Sanchez-Monge R, Lombardero M, Garcia-Selles FJ, Barber D, Salcedo G. Lipid-transfer proteins are relevant allergens in fruit allergy. J Allergy Clin Immunol. 1999;103(3 Pt 1):514–9.

    Article  CAS  PubMed  Google Scholar 

  • Scheurer S, Wangorsch A, Haustein D, Vieths S. Cloning of the minor allergen Api g 4 profilin from celery (Apium graveolens) and its cross-reactivity with birch pollen profilin Bet v 2. Clin Exp Allergy. 2000;30:962–71.

    Article  CAS  PubMed  Google Scholar 

  • Steckelbroeck S, Ballmer-Weber BK, Vieths S. Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes. J Allergy Clin Immunol. 2008;121:1323–30.

    Article  CAS  PubMed  Google Scholar 

  • Tamburrini M, Cerasuolo I, Carratore V, Stanziola AA, Zofra S, Romano L, Camardella L, Ciardiello MA. Kiwellin, a novel protein from kiwi fruit. Purification, biochemical characterization and identification as an allergen*. Protein J. 2005;24:423–9.

    Article  CAS  PubMed  Google Scholar 

  • Toda M, Reese G, Gadermaier G, Schulten V, Lauer I, Egger M, Briza P, Randow S, Wolfheimer S, Kigongo V, Del Mar San Miguel Moncin M, Fotisch K, Bohle B, Vieths S, Scheurer S. Protein unfolding strongly modulates the allergenicity and immunogenicity of Pru p 3, the major peach allergen. J Allergy Clin Immunol. 2011;128:1022–30.

    Google Scholar 

  • Tuppo L, Giangrieco I, Palazzo P, Bernardi ML, Scala E, Carratore V, Tamburrini M, Mari A, Ciardiello MA. Kiwellin, a modular protein from green and gold kiwi fruits: evidence of in vivo and in vitro processing and IgE binding. J Agric Food Chem. 2008;56:3812–7.

    Article  CAS  PubMed  Google Scholar 

  • Vejvar E, Himly M, Briza P, Eichhorn S, Ebner C, Hemmer W, Ferreira F, Gadermaier G. Allergenic relevance of nonspecific lipid transfer proteins 2: identification and characterization of Api g 6 from celery tuber as representative of a novel IgE-binding protein family. Mol Nutr Food Res. 2013;57:2061–70.

    Article  CAS  PubMed  Google Scholar 

  • Zuidmeer L, Goldhahn K, Rona RJ, Gislason D, Madsen C, Summers C, Sodergren E, Dahlstrom J, Lindner T, Sigurdardottir ST, McBride D, Keil T. The prevalence of plant food allergies: a systematic review. J Allergy Clin Immunol. 2008;121:1210–8.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center of Dermatology and Allergology, Kantonsspital Luzern, Lucerne, Switzerland

    B. K. Ballmer-Weber

  2. Department of Dermatology, University Hospital Zürich, Zurich, Switzerland

    B. K. Ballmer-Weber

  3. Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria

    K. Hoffmann-Sommergruber

Authors
  1. B. K. Ballmer-Weber
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Hoffmann-Sommergruber
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to B. K. Ballmer-Weber .

Editor information

Editors and Affiliations

  1. Professor of Dermatology and Allergology, Allergy and Asthma Center Westend Outpatient Clinic Hanf, Ackermann and Kleine-Tebbe, Berlin, Germany

    Jörg Kleine-Tebbe

  2. Professor of Dermatology and Allergology Chairman of the Department of Dermatology and Allergology, University Medical Center Gießen and Marburg Campus Gießen Justus Liebig University Gießen, Gießen, Germany

    Thilo Jakob

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Ballmer-Weber, B.K., Hoffmann-Sommergruber, K. (2017). Molecular Diagnostics of Allergy to Fruits and Vegetables. In: Kleine-Tebbe, J., Jakob, T. (eds) Molecular Allergy Diagnostics. Springer, Cham. https://doi.org/10.1007/978-3-319-42499-6_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-42499-6_14

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42498-9

  • Online ISBN: 978-3-319-42499-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation