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Marker Allergens and Panallergens in Tree and Grass Pollen Allergy

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Molecular Allergy Diagnostics

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Abstract

Many allergens from grasses and trees share structural similarities that result in IgE cross-reactivity. Some of these allergens are defined as marker allergens because immunoreactivity indicates sensitization to specific botanical families of grasses or trees, whereas other allergens are classified as panallergens because they elicit immunoreactivity to many unrelated allergen sources. These allergens are presented and discussed. It is concluded that the use of recombinant marker allergens in clinical routine work improves the accurate diagnosis of allergy for the prescription of immunotherapy.

The present chapter is based on and modified from an article by the authors published in 2015 in Allergo Journal International (Gangl K, Niederberger V, Valenta R, Nandy A: Marker allergens and pan allergens in tree and grass pollen allergy. Allergo J Int 2015, 24:158–169).

The authors gratefully thank Greg Plunkett PhD, ALK Inc. Headquarters and Analytical Laboratories, Round Rock, TX, USA, for reviewing the manuscript and for his editorial assistance and helpful suggestions including a North American perspective.

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Abbreviations

CCD:

Cross-reactive carbohydrate determinants

cDNA:

Complementary deoxyribonucleic acid

CRD:

Component resolved diagnostics

Fab:

Antigen-binding fragment

IgE:

Immunoglobulin E

LTP:

Lipid transfer protein

nsLTP:

Nonspecific lipid transfer protein

OAS:

Oral allergy syndrome

PR-10:

Pathogenesis-related proteins

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria

    K. Gangl MD & V. Niederberger MD, Prof.

  2. Centre for Children’s Health Research, Institute of Health and Biomedical Innovation, Queensland University of Technology, South Brisbane, QLD, Australia

    J. M. Davies PhD, Prof.

  3. Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria

    R. Valenta MD, Prof.

  4. Business Unit Allergy, Research & Development, Allergopharma GmbH and Co. KG, Reinbek, Germany

    A. Nandy PhD

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  1. K. Gangl MD
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  2. V. Niederberger MD, Prof.
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  3. J. M. Davies PhD, Prof.
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  4. R. Valenta MD, Prof.
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  5. A. Nandy PhD
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Correspondence to K. Gangl MD .

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  1. Professor of Dermatology and Allergology, Allergy and Asthma Center Westend Outpatient Clinic Hanf, Ackermann and Kleine-Tebbe, Berlin, Germany

    Jörg Kleine-Tebbe

  2. Professor of Dermatology and Allergology Chairman of the Department of Dermatology and Allergology, University Medical Center Gießen and Marburg Campus Gießen Justus Liebig University Gießen, Gießen, Germany

    Thilo Jakob

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Gangl, K., Niederberger, V., Davies, J.M., Valenta, R., Nandy, A. (2017). Marker Allergens and Panallergens in Tree and Grass Pollen Allergy. In: Kleine-Tebbe, J., Jakob, T. (eds) Molecular Allergy Diagnostics. Springer, Cham. https://doi.org/10.1007/978-3-319-42499-6_10

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