Abstract
Salivary gland malignancies are uncommon, representing 1–6% of head and neck malignancies and 0.3% of all cancers (55% occur in parotid gland, 30% in submandibular gland, 10–15% in the sublingual and minor salivary glands). The majority of salivary gland tumors are primarily managed surgically followed by radiation ± chemotherapy. Indications for postoperative radiation include intermediate-/high-grade tumor, close/positive margins, lymph node metastases, and lymphovascular invasion as well as T3/T4 tumors or recurrent disease in some circumstances. The role of postoperative chemoradiation for high-risk salivary tumors is currently the subject of the ongoing RTOG 10-08 trial (NCT01220583). Unresectable cases are often managed with radiation therapy, preferably with concurrent systemic therapy.
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Leeman, J.E. et al. (2018). Salivary Gland Tumors. In: Lee, N., et al. Target Volume Delineation and Treatment Planning for Particle Therapy. Practical Guides in Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42478-1_8
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DOI: https://doi.org/10.1007/978-3-319-42478-1_8
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